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by Keyword: Poly(ethylene glycol) (peg)
Muñoz-López, J, Hu, L, Wang, H, Tian, XH, Ruiz-Pérez, L, Battaglia, G, (2026). Hydrophilic Janus Micelles From an ABC Triblock Copolymer ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 65, e17752 
We describe the creation of an amphiphilic triblock copolymer that drives lateral phase separation within micelle coronas. The design combines a hydrophobic poly(lactide) (PLA) core-forming block with two distinct hydrophilic segments: poly(ethylene glycol) (PEG) and poly(N-vinylpyrrolidone) (PVP). In water, the copolymer assembles into spherical micelles, confirmed by cryogenic TEM and multi-angle light scattering. Selective end-labelling of PVP with an electron-dense iridium complex enabled unstained TEM imaging, revealing clear contrast asymmetry that locates PVP to a single hemisphere of the corona. Complementary 2D 1H-Nuclear Overhauser Effect Spectroscopy (1H-NOESY) NMR confirmed this Janus-type segregation of PEG and PVP. These results demonstrate how molecular architecture can encode asymmetry into soft nanostructures, offering a versatile route to polymer-based Janus nanoparticles with dual surface functionality and broad technological potential.
JTD Keywords: Amphiphilic copolymers, Janus particles, Poly(ethylene glycol) (peg), Poly(lactide) (pla), Poly(n-vinylpyrrolidone) (pvp)
