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by Keyword: PVP
Muñoz-López, J, Hu, L, Wang, H, Tian, XH, Ruiz-Pérez, L, Battaglia, G, (2026). Hydrophilic Janus Micelles From an ABC Triblock Copolymer ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 65, e17752 
We describe the creation of an amphiphilic triblock copolymer that drives lateral phase separation within micelle coronas. The design combines a hydrophobic poly(lactide) (PLA) core-forming block with two distinct hydrophilic segments: poly(ethylene glycol) (PEG) and poly(N-vinylpyrrolidone) (PVP). In water, the copolymer assembles into spherical micelles, confirmed by cryogenic TEM and multi-angle light scattering. Selective end-labelling of PVP with an electron-dense iridium complex enabled unstained TEM imaging, revealing clear contrast asymmetry that locates PVP to a single hemisphere of the corona. Complementary 2D 1H-Nuclear Overhauser Effect Spectroscopy (1H-NOESY) NMR confirmed this Janus-type segregation of PEG and PVP. These results demonstrate how molecular architecture can encode asymmetry into soft nanostructures, offering a versatile route to polymer-based Janus nanoparticles with dual surface functionality and broad technological potential.
JTD Keywords: Amphiphilic copolymers, Janus particles, Poly(ethylene glycol) (peg), Poly(lactide) (pla), Poly(n-vinylpyrrolidone) (pvp)
Castillo-Fernandez, Oscar, Salieb-Beugelaar, Georgette B., van Nieuwkasteele, Jan W., Bomer, Johan G., Arundell, Martin, Samitier, Josep, van den Berg, Albert, Eijkel, Jan C. T., (2011). Electrokinetic DNA transport in 20 nm-high nanoslits: Evidence for movement through a wall-adsorbed polymer nanogel 
Electrophoresis , 32, (18), 2402-2409
The electrokinetic transport behavior of lambda-DNA (48 kbp) in 20 nm-high fused-silica nanoslits in the presence of short-chain PVP is investigated. Mobility and video data show a number of phenomena that are typical of DNA transport through gels or polymer solutions, thus indicative of rigid migration obstacles in the DNA pathway. Calculations show that a several nanometer thin layer of wall-adsorbed PVP ('nano-gel') can provide such a rigid obstacle matrix to the DNA. Such ultrathin wall-adsorbed polymer layers represent a new type of matrix for electrokinetic DNA separation.
JTD Keywords: λ-DNA, Biased reptation, Caterpillar movement, Nanoslits, Pathways, PVP
