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Quasi-living systems: Merge and Emerge (NET-QUASI)

Description

Nature builds materials, cells, tissues, and organisms by the dynamic assembly of building blocks spanning multiple scales and hierarchies, leveraging complexity and emergence to confer unparalleled functionality, selectivity, adaptability, and interactivity far beyond synthetic materials. Our network aims to study, emulate, and create materials that embody key traits of living matter, forming a new field we call “Quasi-living systems.”  

These materials can be designed with enhanced precision to exhibit self-repair properties, responsiveness, adaptability and interactivity. This innovative strategy will give us a unique opportunity to generate a completely new class of responsive systems with the potential to overcome some of the current limitations and safety concerns associated with living cells. The possibility of learning by merging synthetic and natural blocks will not only allow us to generate unprecedented systems but will also provide valuable insights into how biology tackles complex challenges, guiding the design of versatile, adaptive materials. 

NET-QUASI counts on the participation of the following IBEC research groups:  

Contact us:

Main contact: nkostina@ibecbarcelona.eu 
Additional contact: aleroux@ibecbarcelona.eu 

Network Members

The members of this network have very complementary scientific backgrounds, ranging from chemistry (Kostina, Guillamat), membrane biochemistry, and biophysics (Le Roux, Kostina) to self-assembly (Kostina, Guillamat, Crespo, Gosh) and collective behaviors (Guillamat, Crespo), as well as diverse technical skills, including cell membrane mechanics (Le Roux), and advanced imaging (Kostina, Guillamat, Le Roux).   

Network Coordinator

Nina Kostina

Ramon y Cajal Senior Researcher

She pioneers synthetic models of cell membranes.

    
Network Representatives:  

Anabel-Lise Le Roux

Senior Scientist

She studies cell membrane mechanics using advanced microscopy.  

Pau Guillamat

Postdoctoral Researcher

He works on synthetic living materials.

Subhadip Ghosh

Beatriu de Pinós Fellow

He focuses on hybrid vesicles for bioimaging and chemotaxis.  

María Crespo-Cuadrado

Postdoctoral Researcher

She develops 3D tissue models for biomedical applications. 

Network Programme

NET-QUASI will organize 4 half-day workshops (WS) and a final retreat. Each workshop will feature a distinguished national or international expert and IBEC speakers. Each workshop will consist of a half day of presentations starting with the combined presentation of the IBEC group and then be dedicated to the invited speaker talks, followed by “meet the speaker catering”. 

Workshops Topics. Speakers and dates to be confirmed.   

Workshop 1 (February/March 2025): Coaching Session on Biomimicry Basics: Innovating with Nature’s Strategies 

This workshop will introduce the fundamentals of biomimicry and its application as an innovative design methodology. Through an exploration of the Biomimicry Design Spiral – Identify, Translate, Discover, Abstract, Emulate, and Evaluate. The session will include practical examples and interactive activities to demonstrate how biomimicry can inspire sustainable and effective solutions in diverse fields. 

 

Workshop 2 (March/April 2025): Creating the Building Blocks of Life: Bioinspired Material Design 

This workshop will explore the cutting-edge field of bioinspired material design, focusing on creating functional materials that mimic nature’s strategies to achieve life-like behavior. It will bring together leading scientists, including an invited speaker, researchers from Spain, and IBEC members, to present their advances in designing materials with specific functionalities inspired by natural systems 

Workshop 3 (April-June 2025): Reconstituting Cellular Machines 

This workshop will feature presentation of works on the reconstitution of essential hallmark functions of living cells within artificial/synthetic systems. Mimicking these functions in controlled environments provides valuable insights into the complexities of cellular machinery and enables the development of innovative materials. The workshop will bring together national and international researchers and will foster discussions on the intersection of biology, engineering, and materials science. 

Workshop 4 (September-November 2025): Engineering Smart Materials: Programming Cellular Behavior for Therapeutic Solutions 

This workshop will be devoted to the design and development of materials with tunable properties that instruct living cells. By exploring the interactions between living cells and inert matter, researchers aim to direct cellular functions for therapeutic applications. The workshop will bring together national and international researchers, with a special focus on expertise in cellular mechanics, tissue dynamics, and bioinspired material design. 

The final retreat will feature two invited speaker talks, a selection of presentations from postdocs and senior researchers, and a career development roundtable discussion with senior PIs and speakers.  

All IBEC groups are welcome to join the network and actively participate by sharing their insights.