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Online IBEC Seminar: Samuel Sánchez
Dimarts, abril 28, 2020 @ 4:00 pm–6:00 pm
BioEngineering Hybrid Robotic Machines: from nanobots to 3D Bioprinted Robots
Samuel Sánchez , IBEC
The combination of biological components and artificial ones emerges into what we called hybrid machines/bots/robots. Here, I will present two types of hybrid systems that we are currently developing in our lab which span across different length scales, from a few nanometers to centimeters.
Alike bacteria or small swimmers found in nature, these artificial nanobots convert bio-available fuels to generate propulsion force to swim at the nanoscale. One of the dreams in nanotechnology is to engineer small vehicles which can eventually be applied in vivo for medical purposes. In the first part of my talk, I will present how we bioengineer our hybrid nanobots combining the best from the two worlds: biology (enzymes) and (nano)technology (nano- micro-particles) providing swimming capabilities, biocompatibility, remote control, multifunctionality and actuation. I will present some of the proof-of-concept applications such as the efficient transport of drugs into cancer cells and spheroids, sensing capabilities and the use of molecular imaging techniques for their tracking and localization both in vitro and in vivo.
In the second part of my talk, I will present the 3D bioprinting technique to fabricate hybrid 3D BIOBOTS which provides flexibility, scalability, rapid prototyping and simplicity. This technique has emerged as a powerful tool for the development of functional three-dimensional tissues and, in particular, skeletal muscle. By electrical stimulation, we studied the adaptability of 3D hybrid Robots after long-term trainings and the force evolution during the trainings together with the dynamic gene expression. Two types of devices are bioengineered in our lab: (i) 3D Actuators which useful force measurement platform for drug screening against dystrophies and (ii) 3D BIOBOTS that can be a next generation of living soft robotics systems with swimming capabilities.
The seminar will take place online at the GoToMeeting Platform
Know more about Samuel Sánchez’s research here