DONATE

Smart nano-bio-devices

ABOUT

We develop different Systems ranging from active nanoparticles (nanobots) to 3D Bioprinted Actuators. We are interested in fundamental studies of active matter, the use of nanobots for future nanomedicine, and the bioengineering of new devices based on hybrid systems.


Nanomotors | Biomedical applications 

Bladder cancer team 

Our group employs urease-powered nanobots as an innovative approach to treating bladder cancer. We have demonstrated that these nanobots can enhance anti-cancer drug delivery in vitro, improve the targeting of 3D bladder cancer spheroids, and sense their surrounding environment.

Additionally, we have recently reported their application in vivo, showing their ability to move inside the bladder of healthy mice, accumulate in bladder tumors, and effectively treat bladder cancer using radionuclide therapy. Our goal is to advance this technology towards clinical translation to ultimately improve patients’ lives. 

Nanobots can deliver drugs and penetrate 3D bladder cancer spheroids using urea as a bioavailable fuel. Moreover, they can move collectively inside the bladder of mice, accumulate in bladder tumors, and treat them effectively.

Read more:

Urease-powered nanobots for radionuclide bladder cancer therapy
Cristina Simó*, Meritxell Serra-Casablancas*, Ana C Hortelao, Valerio Di Carlo, Sandra Guallar-Garrido, Sandra Plaza-García, Rosa Maria Rabanal, Pedro Ramos-Cabrer, Balbino Yagüe, Laura Aguado, Lídia Bardia, Sébastien Tosi, Vanessa Gómez-Vallejo, Abraham Martín, Tania Patiño, Esther Julián, Julien Colombelli, Jordi Llop, Samuel Sánchez
Nature Nanotechnology (2024) 19, 554–564

Swarming behavior and in vivo monitoring of enzymatic nanomotors within the bladder
Ana C Hortelao*, Cristina Simó*, Maria Guix, Sandra Guallar-Garrido, Esther Julián, Diana Vilela, Luka Rejc, Pedro Ramos-Cabrer, Unai Cossío, Vanessa Gómez-Vallejo, Tania Patiño, Jordi Llop, Samuel Sánchez
Science Robotics (2021)
6, abd2823

Targeting 3D Bladder Cancer Spheroids with Urease-Powered Nanomotors
Ana C. Hortelão, Rafael Carrascosa, Nerea Murillo-Cremaes, Tania Patiño, Samuel Sánchez
ACS nano (2019), 13, 429-439

Enzyme‐Powered Nanobots Enhance Anticancer Drug Delivery
AC Hortelão, T Patiño, A Perez‐Jiménez, À Blanco, S Sánchez
Advanced Functional Materials (2018), 28, 1705086

Videos:


Nanomotors | Fundamental aspects

1. Swarming nanomotors team

We are exploring the mechanisms behind the swarming behaviour of enzymatic nanomotors. Our findings reveal that the collective buoyancy-driven dynamics of enzymatic nanomotors arises from the density difference between the product-rich particulate and the denser environment. The convective dynamics resembles bioconvection, a self-organized and self-sustained vortex motion that arises naturally in suspensions of microorganisms. The nanomotor swarm moves upward and forms a thin boundary layer fluid in the presence of an upper surface, which becomes unstable, leading to the formation of falling plumes. We are excited by the emergent collective behavior of these nanomotors and are eager to investigate their guidance and uncover more intriguing phenomena. 

The collective buoyancy-driven dynamics of enzymatic nanomotors in three dimensions. Chemical reactions occurring on the particle surface produce ammonia and carbon dioxide, making the particulate less dense and accelerating the upward movement. Vertical confinement shapes the swarms by affecting fluid convective flows. These results provide insight into the buoyancy-driven swarming behaviour of nanomotors. 

Read more:

Collective buoyancy-driven dynamics in swarming enzymatic nanomotors
Shuqin Chen, Xander Peetroons, Anna C Bakenecker, Florencia Lezcano, Igor S Aranson, Samuel Sánchez
Nat Commun (2024), 15, 9315

2. Enzyme catalyst team 

The main drivers of enzyme-powered nanomotors (NMs) are enzymes. In this context, our group are keen to study the parameters that influence enzyme stability and catalysis of the enzyme (e.g., purity), as well as uncovering the mechanisms of motion and their interactions with the environment. We focus on several types of enzymes, including urease, acetylcholinesterase, glucose oxidase, and catalase, with urease serving as our gold-standard enzyme due to its intrinsic properties. 

In recent years, we have reported key findings on the fundamental nature of NMs. Notably, we observed that self-propulsion is inherently linked to the enzyme’s catalytic activity, with conformational changes and turnover rate being essential factors. Additionally, the size and charge of substrates and products significantly influence propulsion. The ionic environment also plays a modulatory role, i.e., salts tend to reduce self-propulsion, whereas movement is enhanced in pure water. 

Furthermore, enzyme purity is critical for improving NMs’ motility. Beyond activity alone, the spatial distribution of the enzyme on the particle surface plays a pivotal role in effective motion, with an asymmetric distribution being a conditio sine qua non. These studies have made fundamental contributions to the field, paving the way for a deeper understanding of the behavior of these nanoscale machines. 

The conformational changes of the helix-turn-helix motif (flap), degree of purity, optimal enzymes concentration, interplay NMs-surrounding and asymmetry distribution of urease in the nanoparticle are key factors influencing motion dynamics. 

Read more:

Unveiling protein corona formation around self-propelled enzyme nanomotors by nanoscopy 
Patiño, T., Llacer-Wintle, J., Pujals, S., Albertazzi, L., & Sánchez, S. Nanoscale (2024), 16(6), 2904-2912. Doi: 10.1039/d3nr03749e

Ionic Species Affect the Self-Propulsion of Urease-Powered Micromotors.   
Xavier Arqué, Xavier Andrés, Rafael Mestre, Bernard Ciraulo, Jaime Ortega Arroyo, Romain Quidant, Tania Patiño, and Samuel Sánchez. Research (2020), 2424972. Doi: 10.34133/2020/2424972.  

Influence of Enzyme Quantity and Distribution on the Self-Propulsion of Non-Janus Urease-Powered Micromotors.    
Tania Patiño, Natalia Feiner-Gracia, Xavier Arque,́ Albert Miguel-Lopez, Anita Jannasch, Tom Stumpp, Erik Schaff̈er, Lorenzo Albertazzi, and Samuel Sánchez. JACS (2018), 140, 7896-7903.  

Enzyme Purification Improves the Enzyme Loading, Self-Propulsion, and Endurance Performance of Micromotors. 
Morgane Valles, Sílvia Pujals, Lorenzo Albertazzi, and Samuel Sánchez. ACSnano (2022), 16(4), 5615-5626. 10.1021/acsnano.1c10520.  


Intra-articular team 

Our group has developed a tandem of nanomotors designed to modulate synovial fluid viscosity in joints. The first set, hyaluronidase-based nanomotors, reduces the viscosity in a controlled manner. Following this, a second set of urease-based nanomotors is introduced, enabling enhanced motion in highly dense environments. This dual approach expands the exploration area of the nanomotors, potentially allowing them to reach and interact with cartilage. 

Read more:

Swarms of Enzyme‐Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media
N. Ruiz-González, D. Esporrín-Ubieto, A. C. Hortelao, J.C. Fraire, A. C. Bakenecker, M. Guri-Canals, R. Cugat, J. M. Carrillo, M. Garcia-Batlletbó, P. Laiz, T. Patiño, S. Sánchez. Small (2024), 20, 230987. DOI: 10.1002/smll.202309387


Gene & Light Therapies team 

We develop nanobots that act as nanocarriers for gene therapy, with a particular emphasis on using biodegradable and biocompatible materials. We also investigate light-triggered effects on nanobots with photothermal properties to overcome extra- and intracellular barriers and trigger immunogenic cell killing. 

Our approach is based on the combination of three main areas: 1. Designing nanocarriers for delivering nucleic acid therapeutics (siRNA, mRNA, pDNA). 2. Studying and applying photothermal and photomechanical effects through the irradiation of light-responsive nanoparticles.  3. Exploring the collective displacement of nanobots. 

Nanorobots loaded with plasmid DNA enable gene delivery and expression of green fluorescent protein (eGFP) in 3D bladder cancer spheroids. Enzyme powered iron oxide nanobots induce the formation of vapor nanobubbles upon laser irradiation allowing photomechanical disruption of collagen fibers. 

Read more:

Light-Triggered Mechanical Disruption of Extracellular Barriers by Swarms of Enzyme-Powered Nanomotors for Enhanced Delivery.  
Fraire, J. C., Guix, M., Hortelao, A. C., Ruiz-González, N., Bakenecker, A. C., Ramezani, P., Hinnekens, C., Sauvage, F., de Smedt, S. C., Braeckmans, K., & Sánchez, S. 
ACS Nano (2023), 17(8), 7180–7193

 

3D BioPrinted Soft Robotics

In the research line of soft bio-hybrid robotics, we explore the integration of biological tissue and artificial materials at larger length scales. In particular, we take advantage of the 3D bioprinting technique to develop bio-robotic systems composed of skeletal muscle cells embedded in biocompatible hydrogels, which can be 3D bioprinted alongside other artificial materials. Theses materials can act as scaffolds, support, or flexible parts, as well as be responsive upon certain stimuli. By controlling the contractions of skeletal muscle cells via electric fields, we can measure the forces exerted by these bio-actuators against artificial 3D-printed posts. Using this setup, we have performed studies on the adaptability of bio-actuators after applying different training protocols and we have observed how their force generation and gene expression can adapt to the frequency of stimulation and stiffness of the artificial posts. 

3D-bioprinted bio-actuator based on skeletal muscle used as a force measurement platform. Upon electrical stimulation, the muscle can contract, bend the post and their force can be calculated.

Read more:

3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes  
Rafael Mestre, Nerea García, Tania Patiño, Maria Guix, Judith Fuentes, Mauricio Valerio-Santiago, Núria Almiñana, Samuel Sánchez
Biofabrication (2021) 13, 045011 

Bio-hybrid soft robots with self-stimulating skeletons
Maria GuixRafael Mestre, Tania Patiño, Marco De Corato, Judith Fuentes, Giulia Zarpellon, Samuel Sánchez
Science Robotics (2021) 21, eabe7577

Design, optimization and characterization of bio-hybrid actuators based on 3D-bioprinted skeletal muscle tissue
Rafael Mestre, Tania Patiño, Maria Guix, Xavier Barceló, Samuel Sánchez
Biomimetic and Biohybrid Systems (2019) 8th International Conference, Living Machines 2019
Lecture Notes in Computer Science,  Springer International Publishing (Nara, Japan) 11556, 205-215
 

Force Modulation and Adaptability of 3D‐Bioprinted Biological Actuators Based on Skeletal Muscle Tissue
Rafael Mestre, Tania Patiño, Xavier Barceló, Shivesh Anand, Ariadna Pérez‐Jiménez, Samuel Sánchez
Advanced Materials Technologies (2018): 1800631 

Miniaturized soft bio-hybrid robotics: a step forward into healthcare applications
Tania Patino, Rafael Mestre, Samuel Sánchez
Lab Chip (2016) 1619, 3626-3630


Previous research

Active matter in complex systems 

We study colloidal suspensions of Pt-coated silica particles as a model system of synthetic active matter. These systems have mostly been studied in homogeneous environments until now. Our interest lies in observing these systems in more complex settings, such as near interfaces, complex media or with flow involvedSince the self-propelled particles generate chemical and hydrodynamic fields around them, they interact in complex ways with flows and nearby surfaces that often leads to interesting behaviour. We could find, for instance, that close to solid surfaces they achieve a stable ‘gliding’ state which could be exploited to develop a system for guiding micro-nano motors using topographical features as shown with our micropatterned ratchets. When flow is present, particles also behave different as they reorient perpendicular to the flow. 

We recently published the collective guidance of out-of-equilibrium systems without using external field, designing an strategy to achieve directed motion without breaking detailed balance, for example by asymmetric topographical patterning. We engineer a two-dimensional periodic topographical design to spontaneous particle edge guidance and corner accumulation of self-propelled particles. This emergent behaviour is guaranteed by a second-order non-Hermitian skin effect, stablishing a fruitful bridge between active and topological matter.

Phoretic and hydrodynamic interactions with nearby surfaces and flows can be exploited to create a guidance mechanism for self-propelled particles
Topological device that displays chiral edge modes at the top and bottom, and which are related to a non-vanishing Hermitian topological invariant.

Read more:

Guided accumulation of active particles by topological design of a second-order skin effect
Lucas S. Palacios, Serguei Tchoumakov, Maria Guix, Ignacio Pagonabarraga, Samuel Sánchez, Adolfo G. Grushin
Nature Communications (2021) 12, 4691

Self-propulsion of active colloids via ion release: Theory and experiments
Marco De Corato, Xavier Arqué, Tania Patiño, Marino Arroyo, Samuel Sánchez, Ignacio Pagonabarraga
Physical Review Letters (2020) 124,  108001

Guidance of active particles at liquid-liquid interfaces near surfaces
Lucas Palacios, Jaideep Katuri, Ignacio Pagonabarraga and Samuel Sánchez
Soft Matter (2019) 15, 6581-6588

Directed Flow of Micromotors through Alignment Interactions with Micropatterned Ratchets
Jaideep Katuri, David Caballero, Raphael Voituriez, Josep Samitier and Samuel Sánchez
ACS Nano (2018)127282-7291 

Cross-stream migration of active particles
Jaideep Katuri, William E. Uspal, Juliane Simmchen, Albert Miguel-López, Samuel Sánchez
Science Advances (2018) 4 

Topographical Pathways Guide Chemical Microswimmers
Juliane Simmchen, Jaideep Katuri, William E. Uspal, Mihail N. Popescu, Mykola Tasinkevych, and Samuel Sánchez
Nature Communications (2016) 7 , 10598

Videos:


(Flexible) Biosensors for non-invasive Point-of-Care diagnostics 

Point-of-care diagnostics allows decentralizing clinical diagnostic practices and monitoring health out of specialized hospital settings. Advantages of such decentralization are improved quality of life of patients, enhanced therapeutic efficacy thanks to more frequent tests, and lower overall cost of the health system. We develop flexible biochemical sensors for non-invasive and cost-effective monitoring of analytes in biological fluids alternative to blood, e.g. sweat, tears, and saliva. We combine electrochemical electrochemical sensors with microfluidics and electronics to achieve fully integrated devices, that are well suited for low-cost, portable and user-friendly medical diagnostics. 

Electrodes fabricated on flexible substrates are modified with a wide range of materials for selectivity towards biomarkers. Analytes are quickly quantified by electrochemical techniques.

Read more:

Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis
Agostino Romeo, Ana Moya, Tammy S. Leung, Gemma Gabriel, Rosa Villa and Samuel Sánchez
Applied Materials Today (2018) 10, 133-141

Smart biosensors for multiplexed and fully integrated point-of-care diagnostics
Agostino Romeo, Tammy Sue Leung, and Samuel Sánchez
Lab Chip (2016) 16, 1957-1961

Flexible sensors for biomedical technology
Diana Vilela, Agostino Romeo, and Samuel Sánchez
Lab Chip (2016) 16, 402-408


[

STAFF


Samuel Sánchez Ordóñez

Group Leader / ICREA Research Professor
+34 934 020 558
ssanchezibecbarcelona.eu

Alumni

  • Àngel Blanco Blanes | 2015-2021 Lab technitian (IBEC)
  • Dr. Morgane Valles | 2019-2021 Postdoctoral researcher (IBEC)
  • Dr. Ana C. Hortelão | 2015-2021 PhD candidate and Postdoctoral researcher (IBEC)
  • Ferran Blasi Moreno | 2021  TFG student (Institut Químic de Sarrià IQS, Spain)
  • María Porteiro Figueiras | 2021  Master student (University of Barcelona, Spain)
  • Paz Aragón Chivite | 2021  TFG student (Autonomous University of Barcelona, Spain)
  • Ibtissam Ghailan Tribak  | 2021  TFG student (University of Barcelona, Spain)
  • Arnau Llobera Ris | 2021  TFG student (University of Barcelona, Spain)
  • Chiara Greco | 2020 Master student (Politecnico di Torino, Italy)
  • Giulia Zarpellon | 2018-2019 Research Assistant
  • Dr. Lei Wang | 2018-2020  Postdoctoral researcher (IBEC) | Current position: Professor at Harbin Institute of Technology
  • Nerea García | 2020 Master student (UB – UPC, Spain)
  • Dr. Paul Soto | 2017-2019 Postdoctoral researcher (IBEC) | Current position: postdoctoral researcher at BIAM in Cadarache
  • Pascal Blersch | 2019 Master student
  • Xavier Andrés | 2019 Master student (University of Barcelona, Spain)
  • Núria Cadefau | 2019 Master student (Université de Lyon, France)
  • Joaquim Llàcer Wintle | 2019  Master student (BIST Barcelona, Spain) | Current position: PhD Candidate at ETH Zürich
  • Roland Rocafort | 2019 Visiting bachelor student MIT
  • Prof. Dong Pyo Kim | 2018 Visiting Researcher
  • Dr. Jemish Parmar | 2015-2019 PhD candidate (IBEC)
  • Dr. Jaideep Katuri | 2015-2019 PhD candidate (Max Planck for Intelligent Systems and IBEC)
  • Dr. Diana Vilela | 2014-2019 Postdoctoral researcher (Max Planck for Intelligent Systems and IBEC) | Current position: Postdoctoral researcher at Universidad Complutense de Madrid
  • Elisabeth Bigorra | 2018 Bachelor student (TFG, Universitat Autònoma de Barcelona)
  • Dr. Agostino Romeo | 2016-2019 Postdoctoral researcher (IBEC) | Current position: Innovation Project Manager at Vall d’Hebron
  • Albert Miguel-López | 2015-2018 Master student and research assistant
  • Liam K. Herndon | 2018 Visiting bachelor student MIT
  • Dr. Mingjun Xuan | 2018 Postdoctoral researcher
  • Ander Eguskiza | 2018 Master student (University Pompeu Fabra, Spain)
  • Carlos Martínez Martin | 2018 Master student (University of Barcelona, Spain)
  • Rafael Carrascosa | 2018 Master student
  • Xavier Barceló | 2018 Master student (University of Barcelona, Spain)
  • Natàlia Salvat | 2018 Master student (University of Barcelona, Spain)
  • Dr. Nerea Murillo-Cremaes | 2017-2018 Postdoctoral Researcher | Current position: Leitat Technological Center
  • Ariadna Pérez-Jiménez | 2015-2018 Group technician
  • Shivesh Anand | 2017 Research assistant
  • Dr. Katherine Villa | 2017-2018 Postdoctoral researcher | Current position: Caixa Junior Leader Fellow at the Insitute of Chemical Research of Catalonia (ICIQ)
  • Sílvia Vicente Rizo | 2017 Master student (University of Barcelona, Spain)
  • Tania Gonçalves | 2016 Master student
  • Dr. Morgan M. Stanton | 2015 Posdoctoral Researcher (Max Planck for Intelligent Systems)
  • Dr. Xing Ma | 2015 Postdoctoral Researcher (Max Planck for Intelligent Systems) | Current position: Harbin Insitute of Technology
  • Dr. Lluís Soler | 2015 Postdoctoral Researcher (Max Planck for Intelligent Systems) | Current position: Institute of Energy Technologies (INTE), UPC (ETSEIB), Barcelona
  • Azaam Aziz | 2015 Master student (Fachhochschule Jena, Germany)
  • Varun Shridar | 2015 Master student (Technische Universitat Darmstadt. Germany)

PROJECTS

NATIONAL PROJECTSFINANCERPI
IBEC’s International PhD Progamme fellowship (2018-2022)Spanish Ministry of Economy and CompetitivenessXavier Arqué
FPI fellowship (2020 – 2024)Spanish Ministry of Economy and CompetitivenessNoelia Ruiz
INTERNATIONAL PROJECTSFINANCERPI
Beatriu de Pinós  · Nanotroops4GT: Enzyme-powered Nanomotor Troops for Gene Therapy by Combining Biological Barriers Disruption and Enhanced Delivery of Nucleic Acid Therapeutics (2022 – 2025)Agaur | MSCA – COFUNDJuan Fraire
i-NANOSWARMS · Cooperative Intelligence in Swarms of Enzyme-Nanobots (2020-2025)European Comission, ERC-CoGSamuel Sánchez
Beatriu de Pinós  · 3DcolorBots: Versatile integration of structural color in 3D printed living robots for advanced control and sensing capabilities (2020 – 2023)Agaur | MSCA – COFUNDMaria Guix
PRIVATELY FUNDED PROJECTSFINANCERPI
BLADDEBOTS Enzyme propelled nanobots as efficient nanotech platform for bladder cancer therapy (2021-2024)Obra Social La Caixa, Health Research Call for Proposals Samuel Sánchez
Feodor-Lynen Fellowship · Biohybrid wing microactuator based on integrated insect muscle cells (2020 – 2022)Alexander von Humboldt FoundationVeronika Magdanz
ENHANCEMENT OF THE THERAPEUTIC EFFECT OF GROWTH FACTORS USING SELF-PROPELLED NANOBOTS (2021-2022)Fundació García-CugatSamuel Sánchez
FINISHED PROJECTSFINANCERPI
IBEC’s International PhD fellowships “la Caixa” Severo Ochoa (2016-2020)Obra Social La CaixaRafael Mestre
Effect of a new cosmectic active ingredient in the regulation of muscular function (2019-2021)Lipotec, S.A.USamuel Sánchez, Tania Patiño
MEDIROBOTS · MEdical micro- and nano-Robots for Molecular Imaging (2018 – 2021)Fundación BBVASamuel Sánchez
TERANOBOTS · Nanorobots for bladder cancer theranostics (2019 – 2021)Obra Social La Caixa / CaixaimpluseSamuel Sánchez
BOTSinFLUIDS · Motion of biocatalytic nanobots in biological fluids and complex media for efficient drug delivery” (2019 – 2021)Spanish Ministry of Science, Innovation and Universities, Retos investigación: proyectos I+DSamuel Sánchez
FPI fellowship (2017 – 2021)Spanish Ministry of Economy and CompetitivenessLucas Palacios
IBEC’s International PhD fellowships Severo Ochoa (2016-2020)Spanish Ministry of Economy and CompetitivenessAna C. Hortelão
Smart nano-bio-devices group
SGR Grups de recerca consolidats (2017-2021)
AGAUR, SGR
BEST An integrated computational and experimental predictive framework for the chemo-hydrodynamics of active catalytic colloidal particles on complex environments (2018-2020)IBEC | MSCA – COFUNDMarco de Corato
2018 BIST Ignite Project · MOFtors- Enzyme-powered, metal-organic framework-based motors (2018)Barcelona Institute of Science and TechnologyVincent Guillerm (ICN2), Tania Patiño (IBEC)
2018 Ignite Project · ElectroSensBioBots Towards a new generation of programable 3D printed living biobots with nanoelectronics for sensing and local stimulation (2018)Barcelona Institute of Science and TechnologyMaria Guix (IBEC) Steven Walston (ICN2)
Efecto de un nuevo ingrediente activo nutraceutico en la regulación de la relajación muscular (2019-2020)Lipofoods, S.L.USamuel Sánchez, Tania Patiño
LABPATCH · Lab-in-a-patch for PKU self-assessment (2018-2020)European Commission, ERC-PoCSamuel Sánchez
Juan de la Cierva Incorporación · 3D printed soft robotics for lab on a chip applications (2018-2020)
Spanish Ministry of Economy and CompetitivenessMaria Guix
ENZWIM Nanomotores de nanopartículas mesoporosas impulsados por enzimas (2017-2019)Spanish Ministry of Economy and Competitiveness, ExploraSamuel Sánchez
BEST · Smart core-double-shell nanoparticles for specific and effective action against bacterial infection at different environments (2017-2019)IBEC | MSCA – COFUNDDiana Vilela
Juan de la Cierva Formación (2017-2019)Spanish Ministry of Economy and CompetitivenessPaul Soto
Microcleaners Active microcleaners for water remediation (2016-2018)European Commission, ERC-PoCSamuel Sánchez
MicroDia Sistemas Lab-on-a-chip basados en micro-nanomotores para el diagnóstico de enfermedades (2016-2018)Spanish Ministry of Economy and Competitiveness, Retos investigación: Proyectos I+DSamuel Sánchez
BEST (2016-2018)IBEC | MSCA – COFUNDAgostino Romeo
Juan de la Cierva Formación (2016-2018)Spanish Ministry of Economy and CompetitivenessTania Patiño
LOC-Systems based on Nano/Micromachines for Food Safety Applications (2014-2016)Alexander von Humboldt FoundationDiana Vilela
Mesoporous Silica Micro/Nano-motors as Active Drug Delivery Vehicles (2014-2016)Alexander von Humboldt FoundationMa Xing
LT-NRBS Lab-in-a-tube and Nanorobotic biosensors (2013-2017)European Commission, ERC-StGSamuel Sánchez

PUBLICATIONS


For a list of publications prior to joining IBEC, visit the MPI for Intelligent Systems website.

EQUIPMENT


Microscopy

  • Leica THUNDER Imager Live Cell & 3D Cell Culture with Computational Clearing to obtain high-speed and high-quality imaging of thick 3D dimensional specimens (Leica Microsystems)
  • Leica DMi8. Inverted Fluorescent microscope with cell incubator, galvo stage for 3D tracking (Leica Microsystems)
  • Leica DMI3000B. Inverted Fluorescent microscope (Leica Microsystems)
  • Leica DMi1. Inverted microscope for Cell Cultures (Leica Microsystems)
  • Leica DM2500MH. Upright microscope (Leica Microsystems)

Characterization

  • Leica EM ACE600. High vacuum sputter & carbon thread coater (Leica Microsystems)
  • Rheometer MCR 702. Dynamic mechanical Analyzer (Anton Paar)
  • Dynamic Light Scattering & Z-Potential (Wyatt)
  • UV-Visible Spectrometer (Analytik Jena)

3D Printing

  • LumenX Bioprinter (Cellink)
  • Form 2 3D printer (Formlabs)
  • Inkredible+ 3D Bioprinter (Cellink)

Surface treatment

  • Oxygen Plasma cleaner (Deiner Electronics)
  • Spin coater (Laurell)
  • Langmuir Blodgett (KSV NIMA)
  • UV Irradiation System (Vilber Lourmat)

Biospace

  • Biological Safety Cabinet Bio II Advance Plus (Telstar)
  • Incubator Galaxy170 S (Eppendorf)
  • Orbital Shaker-Incubator ES-20 (Biosan)
  • Water bath VWB2 (VWR)

Chromatography

  • Fast Protein Liquid Chromatography (Bio-Rad)

Sensing & electronics

  • Autolab Galvostat/Potentiostat (Metrohm)
  • Wave form source; Voltage amplifier (Tabor Electronics)
  • Oscilloscope (Rigol)
  • Portable Potentiostat-Galvanostat and Multiplexer (PalmSens)
  • DC power supply (Hameg)

Microfluidics

  • MFCS-EZ Microfluidic flow control system (Fluigent)
  • AL4000 Aladdin Double Syringe Pump (WPI)

Recording cameras

  • Video camera (1000+ fps) (Hamamatsu)
  • High speed camera (10000+ fps) (Vision Research)
  • CCD video camera (100fps) (Thorlabs)

Others

  • Centrifuge (Eppendorf)
  • Test tube heater; Eppendorf tube Shaker (Hach)
  • Sonicator (VWR)
  • Sonicator (Branson)
  • Vortex (VWR)
  • TOC Analyser (Analytik Jena)
  • Homogenizer (BennetSc)
  • Non-Magnetic Stirrer (Daihan)
  • Thermolyne Furnace (Thermo Scientific)
  • Hydrothermal Reactor (Berghof)
  • DUO 3 Dual Stage Rotary Vane Vacuum Pump (Pfeiffer Vacuum)

COLLABORATIONS

  • Prof. Kevin Braeckmans
    Ghent University, Belgium
  • Prof. Katrien Remaut
    Ghent University, Belgium
  • Prof. Cristina Fornaguera
    Institut Químic de Sarrià (IQS), Spain
  • Prof. José Garrido
    Catalan Institute of Nanosciences and Nanotechnology-ICN2, Spain
  • Prof. Ramón Martínez Mañez
    Universidad Politécnica de Valencia, Spain
  • Prof. Jan van Hest
    Eindhoven University of Technology, Netherlands
  • Prof. Loai Abdelmohsen
    Eindhoven University of Technology, Netherlands
  • Prof. Xing Ma
    Harbin Institute of Technology (Shenzhen), China
  • Prof. Lei Wang
    Harbin Institute of Technology (HIT), China
  • Prof. Islam S. M. Khalil
    University of Twente, Netherlands
  • Dr. Simó Schwartz
    Vall d’Hebron Research Institute (VHIR), Spain
  • Dr. Toni Vilaseca
    Hospital Clínic de Barcelona, Spain
  • Prof. Lorenzo Albertazzi
    Eindhoven University of Technology, Netherlands
  • Prof. Esther Julián Gómez
    Universitat Autònoma de Barcelona (UAB), Spain
  • Prof. Xiaohui Yan
    Xiamen University, China
  • Prof. Adolfo G. Grushin
    Institut Néel (part of CNRS), France
  • Prof. Eduard Torrents Serra
    Institute for Bioengineering of Catalonia (IBEC), Spain
  • Prof. Islam S. M. Khalil
    University of Twente, Netherlands
  • Núria Almiñana Domenech, Mauricio Valerio-Santiago
     Lubrizol Life Science Beauty, USA
  • Prof. Anna Roig
    Materials Science Institute of Barcelona (ICMAB-CSIC), Spain
  • Prof. Ignacio Pagonabarraga
    University of Barcelona, Spain
  • Prof. Vincent Guillem
    KAUST
  • Prof. Marco Filice
    Universidad Complutense de Madrid CNIC, Spain
  • Prof. Romain Quidant
    ETH Zürich, Swtizerland
  • Prof. Silvia Osuna
    University of Girona, Spain
  • Prof. Hailin Huang
    Harbin Institute of Technology (HIT), China
  • Prof. Qiang He
    Harbin Institute of Technology (HIT), China
  • Prof. Joseph Wang
    University of California San Diego (UCSD), USA
  • Prof. D.P. Kim
    National Center of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Korea
  • Prof. S. Dietrich, Dr. M. Popescu, M. Tasinkevych, Dr. W. Uspal
    Theory of Soft Condensed Matter, MPI for Intelligent Systems, Stuttgart, Germany
  • Prof. M. Sitti
    Physical Intelligence department, MPI for Intelligent Systems
  • Prof. R. Di Leonardo
    Universtità La Sapienza, Rome, Italy
  • Prof. J. Sort, Dr. Eva Pellicer
    Physics Department, Universitat Autònoma de Bellaterra (UAB), Spain
  • Dr. D. Esqué
    The School of Materials, The University of Manchester, UK
  • Dr. J. Llop
    CIC BiomaGUNE, San Sebastián, Spain
  • Prof. F. Ricci
    Dipartimento di Scienze e Tecnologie Chimiche Università di Roma Tor Vergata, Rome, Italy
  • Dr. Ll. Soler
    Institute of Energy Technologies (INTE), UPC (ETSEIB), Barcelona
  • Prof. E. Shäffer
    Center for Plant Molecular Biology (ZMBP), University of Tübingen, Germany
  • Dr. L. Albertazzi
    Nanoscopy group, IBEC
  • Prof. J. Samitier
    NanoBioengineering Group, IBEC
  • Dr. D. Caballero
    University of Minho, Portugal
  • Prof. R. Voituriez
    CNRS/Université Pierre et Marie Curie, Paris, France
  • Dr. R. Artuch
    Laboratorio de enfermedades metabólicas hereditarias, Hospital Sant Joan de Déu, Barcelona.

NEWS

The 1st Translational Collaboration Day between the Vall d’Hebron Institute of Research (VHIR) and the Institute of Bioengineering of Catalonia (IBEC), held on 21st November, was an opportunity to learn about the projects and research lines of both institutions and to promote interaction between professionals.

IBEC and VHIR hold a collaboration day to promote synergies

The 1st Translational Collaboration Day between the Vall d’Hebron Institute of Research (VHIR) and the Institute of Bioengineering of Catalonia (IBEC), held on 21st November, was an opportunity to learn about the projects and research lines of both institutions and to promote interaction between professionals.

The latest developments in nanotechnology, biotechnology and medicine were presented at the NanoBio&Med 2024 International Conference, held this week at the Barcelona Science Park (PCB) from 5 to 7 November. This is an annual event designed to establish new collaborations and promote innovative projects in the scientific-industrial sector.

Advances in nanobiotechnology and nanomedicine explored at the 12th International NanoBio&Med Conference

The latest developments in nanotechnology, biotechnology and medicine were presented at the NanoBio&Med 2024 International Conference, held this week at the Barcelona Science Park (PCB) from 5 to 7 November. This is an annual event designed to establish new collaborations and promote innovative projects in the scientific-industrial sector.

IBEC and the Blood and Tissue Bank of Catalonia (BST) held a day to explore new collaborations in bioengineering and translational medicine. The meeting, held yesterday at IBEC, highlighted innovative projects, presented a joint PhD programme and strengthened the link between biomedical research and clinical applications.

IBEC and BST strengthen ties with Translational Collaboration Day

IBEC and the Blood and Tissue Bank of Catalonia (BST) held a day to explore new collaborations in bioengineering and translational medicine. The meeting, held yesterday at IBEC, highlighted innovative projects, presented a joint PhD programme and strengthened the link between biomedical research and clinical applications.

IBEC’s 17th Annual Symposium focused on ‘Bioengineering for Emergent and Advanced Therapies’, one of IBEC’s key application areas. Around 300 people attended the event, including local and international researchers. It was a multidisciplinary environment in which experts from other centres and the IBEC community itself had the opportunity to present their projects and share knowledge.

Bioengineering for Emergent and Advanced Therapies at the 17th IBEC Symposium

IBEC’s 17th Annual Symposium focused on ‘Bioengineering for Emergent and Advanced Therapies’, one of IBEC’s key application areas. Around 300 people attended the event, including local and international researchers. It was a multidisciplinary environment in which experts from other centres and the IBEC community itself had the opportunity to present their projects and share knowledge.

IBEC researcher Samuel Sánchez has received a Leonardo Grant from the BBVA Foundation. The funding will help him take his research a step further and use organic and biocompatible materials to develop his nanorobots, which will be used as drug carriers to treat bladder cancer.

Researcher Samuel Sánchez awarded a Leonardo Grant

IBEC researcher Samuel Sánchez has received a Leonardo Grant from the BBVA Foundation. The funding will help him take his research a step further and use organic and biocompatible materials to develop his nanorobots, which will be used as drug carriers to treat bladder cancer.

Samuel Sánchez, ICREA Research Professor at the Institute for Bioengineering of Catalonia (IBEC), will lead the OrthoBots project, which focuses on the treatment of joint diseases using nanorobots. To carry out the project, Sánchez has been awarded an ERC Proof of Concept Grant, a prestigious grant from the European Research Council.

Nanorobots capable of travelling through synovial fluid to fight arthritis

Samuel Sánchez, ICREA Research Professor at the Institute for Bioengineering of Catalonia (IBEC), will lead the OrthoBots project, which focuses on the treatment of joint diseases using nanorobots. To carry out the project, Sánchez has been awarded an ERC Proof of Concept Grant, a prestigious grant from the European Research Council.

The Nanomotors International Conference was held in Barcelona from 2 to 5 June. The event, organised by the Institute of Bioengineering of Catalonia (IBEC) in collaboration with the ‘la Caixa’ Foundation, the Catalunya La Pedrera Foundation, and the European Research Council (ERC), brought together the most prominent international leaders in the field of nanomotors. For three days, they learned about the latest advances in biomedical applications and the collective behaviour of self-propelled nanomotors, from both experimental and theoretical perspectives.

IBEC celebrates 20th anniversary of nanorobot research

The Nanomotors International Conference was held in Barcelona from 2 to 5 June. The event, organised by the Institute of Bioengineering of Catalonia (IBEC) in collaboration with the ‘la Caixa’ Foundation, the Catalunya La Pedrera Foundation, and the European Research Council (ERC), brought together the most prominent international leaders in the field of nanomotors. For three days, they learned about the latest advances in biomedical applications and the collective behaviour of self-propelled nanomotors, from both experimental and theoretical perspectives.

1 2 3 9

ERC Workshop

Crafting a Winning ERC Proposal: A Workshop with ERC officers and grantees

JOBS

We are happy to receive CVs and enquiries from talented individuals. Prospective students and staff are encouraged to contact us to discuss possibilities. Please feel free to suggest new projects, areas of research or new ideas.

Current job openings in the group are listed on the jobs page.

1 2 3

INVITED TALKS

Invited talks

  • Florencia Lezcano | Invited speaker at the 3D Bioprinting Course “Bioimpresión 3D: Tecnología Emergente en la Frontera entre la Biomedicina y la Ingeniería (4ª edición)” | Overcoming Challenges of Bioprinting Tissue Models Using Python-based GCode Designer | 18-21.06.2024
    Santiago de Compostela, Spain
  • Dr. Juan Fraire | Invited speaker at the nano bio&med 2022 Conference | Light-Triggered Vapor Nanobubbles and Nanomotors for Drug Delivery Applications | 22-24.11.2022
    Barcelona, Spain

  • Prof. Samuel Sánchez | Invited speaker at the ACM International Conference on Nanoscale Computing and Communication | Swarms of chemically powered nanobots as smart nanovehicles | 06.10.2022 ACM NanoCom 2022 || Keynotes
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited speaker at the Workshop on Future of nanomachines organized by IBS of Nanomedicine Institute | Next generation of autonomous Hybrid Robots | 10.11.2021
    Seoul, South Korea
  • Prof. Samuel Sánchez | Invited speaker at the IBS Forum on Nanomachines for Biotechnology and Medicine | Swarms of Hybrid and biocompatible Nanobots for Cancer Nanomedicine | 08-09.11.2021 https://www.ibs-conference.org/2021/nm/
    Seoul, South Korea
  • Prof. Samuel Sánchez | Keynote speaker at Innodays EKFZ | Next generation of medical autonomous microrobots | 25.9.2021. https://digitalhealth.tu-dresden.de/innodays/
    Dresden, Germany
  • Prof. Samuel Sánchez | Keynote speaker at 3-M Nano conference (International Conference on Manipulation, Manu­facturing and  Measurement on the Nanoscale) | Swarms of hybrid nanobots move collectively in mice’s bladder | 02-06.08.2021
    Online Conference
  • Dr. Maria Guix | Invited speaker and panelist in the round table at the Biohybrid robotics workshop, organized in the framework of the International Converence of Biomimetics and Biohybrid Systems, Living Machines 2021 | High performance hybrid robots based on skeletal muscle tissues | 30.07.2021
    Online workshop
  • Prof. Samuel Sánchez | Artificial Molecular Machines workshop, organized by (Merck KGaA, San José, CA, USA) | How to engineer biofriendly nanobots and bring them from in vitro to in vivo | 02.07.2021
    Online seminar
  • Prof. Samuel Sánchez | Organized by ACER Recerca | Premi Extraordinari de Batxillerat | 30.06.2021
    Online seminar
  • Dr. Maria Guix | I encuentro de Mujeres en la Ingeniería, organized by the groups of Afinidad Women in Engineering (WIE) of several universities in Equador | Trayectoría en la ciencia e investigación de alto impacto | 21.06.2021
    Online seminar
  • Prof. Samuel Sánchez | Bienal Ciudad y Ciencia, organized by Barcelona city council | La nit – Pecha Kucha express: art, ciència, tecnologia | 11.06.2021
    Barcelona, Spain
  • Dr. Maria Guix | IEEE NTC YP R9 Webinars, organized by EEE Nanotechnology Council (NTC) Young Professions in the IEEE Latin America (IEEE Region 9) | 3D technologies for the development of living robots | 10.06.2021
    Online seminar
  • Prof. Samuel Sánchez | ICRA 2021 workshop on micro-nano swarm robotics | Monitoring swarms of enzyme-powered nanobots within mouse bladder | 04.06.2021
    Online Workshop
  • Dr. Maria Guix | Maker Faire Galicia | Panelist in round table “Conociendo al Homo Deus” | 03.06.2021
    Online Career Fair
  • Prof. Samuel Sánchez | Nanorobots for Biotechnology, Nature Conference | Microrobots and nanorobots with enzymes: a biocompatible solution towards biomedical applications | 25.05.2021
    Online Conference
  • Dr. Maria Guix | The MultiScale Talk Series, organized by Dr. Zoran Cenev (Aalto University) | Self-stimulating skeletons for living robotics platforms | 24.05.2021
    Online Seminar
  • Dr. Veronika Magdanz | The MultiScale Talk Series, organized by Dr. Zoran Cenev (Aalto University) | Biohybrid microbots – What Sperm can teach us about microrobotics | 10.05.2021
    Online Seminar
  • Prof. Samuel Sánchez | Gira FPdGi, Member of the roundtable on the final act | 29.04.2021
    Alicante, Spain
  • Prof. Samuel Sánchez | Clustering and Global Challenges” (CGC2021) international conference | Swarms of nanorobots: smart nanoparticles swimming in vivo | 09.04.2021
    Online Conference
  • Prof. Samuel Sánchez | 3rd MANA reunion Workshop (NIMS, Japan) | Bioengineering hybrid robots: from nanobots to 3D BioRobots | 04-05.03.2021
    Online Seminar
  • Prof. Samuel Sánchez | Co-organizer and speaker | Crafting a Winning ERC Proposal: A Workshop with ERC officers and grantees | 18.02.2021
    Online Workshop
  • Rafael Mestre | Workshop: Applications of Functional Printing and Bio-Printing in the Health Sector, organized by Grupo INTERPLATAFORMAS: Plataforma3NEO, FENIN, NANOMED AIMPLAS y el Cluster de Impresión Funcional | November 2020
    Invited speaker and round-table​
    Online Workshop
  • Rafael Mestre | Workshop: 3D Bio-printing: advances and applications for the future of medicine, organized by Isaza Scientific (S.A. Madrid) | October 2020
    Invited speaker​
    Online Workshop
  • Dr. Tania Patiño | 2020 BIST Conference, Building a sustainable world together | October 2020
    Speaker at Roundtable I: MOFs, a Powerful Framework for Pollution Remediation​
    Online Conference
  • Dr. Tania Patiño | 2020 BIST Conference, Building a sustainable world together | October 2020
    Speaker at Roundtable I: MOFs, a Powerful Framework for Pollution Remediation​
    Online Conference
  • Prof. Samuel Sánchez | Florida A&M University – Florida State University (FAMU-FSU) CBE Seminar Series | 23.10.2020
    Online Seminar
  • Prof. Samuel Sánchez | NanoBio&Med Online | July 2020
    Online Conference
  • Dr. Maria Guix | International Friends Talk Science | July 2020
    Organized by Nanobioelectronics & Biosensors Group
    Online Seminar
  • Prof. Samuel Sánchez | IBEC Online Seminar | 04.05.2020
    BioEngineering Hybrid Robotic Machines: from nanobots to 3D Bioprinted Robots
    Online Seminar

  • Dr. Marco de Corato | Seminar at l’École Polytechnique de Paris | May 2020
    Organized by Laboratoire d’hydrodynamique
    Online Seminar
  • Prof. Samuel Sánchez | European Research Council (ERC) Conference : “Frontier Research: Creating Pathways to Sustainability” | Keynote speaker and discussion panellist | 2.12.2019
    Tiny self-powered submarines: Nanorobots for clean water
    Brussels, Belgium
  • Prof. Samuel Sánchez | NanoBio&Med 2019 | Keynote talk | 20.11.2019
    Nanomotors: Artificial active matter for nanomedicine
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited AMN Seminar, CEITEC Nanorobots Center | 15.10.2019
    Nanorobots as novel theranostic tools: smart drug delivery and imaging
    Brno, Czech Republic
  • Prof. Samuel Sánchez | Invited Seminar, School of Materials Science and Engineering HIT | 04.09.2019
    Nanomotors for environmental and biological applications
    Shenzhen, China
  • Prof. Samuel Sánchez | Invited Seminar, Engineering Living Systems. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences | 03.09.2019
    Shenzhen, China
  • Prof. Samuel Sánchez | Invited Seminar, SUSTECH University | 02.09.2019
    Nanorobots and Soft Robots
    Shenzhen, China
  • Prof. Samuel Sánchez | Invited Seminar, Chemical Engineering School, HIT Harbin | 29.08.2019
    Chemically powered nanomotor
    Harbin, China
  • Prof. Samuel Sánchez | Keynote talk, Workshop on nanorobots for medicine, HIT Harbin | 28.08.2019
    Chemical nanorobots for medicine
    Harbin, China
  • Prof. Samuel Sánchez | Invited talk, 2nd International Conference on Micro/Nanomachines | 28.08.2019
    Enzyme-powered hybrid micro-nano-motors: Fundamentals towards applications
    Harbin, China
  • Prof. Samuel Sánchez | Invited talk, Xiamen University | 24.08.2019
    Nanomotors and Biobots
    Harbin, China
  • Prof. Samuel Sánchez | International Workshop – Microscale Motion and Light | 24.08.2019
    Enzyme-powered nanomotors from fundamentals to applications
    Dresden, Germany
  • Dr. Maria Guix | International Workshop – Microscale Motion and Light | July 2019
    Organized by Max Planck Institute for the Physics of Complex Systems
    Dresden, Germany 
  • Prof. Samuel Sánchez | IBEC-ICMS Symposium | 16.07.2019
    Engineering living systems across length scales
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited seminar, University Tor Vergata | 15.07.2019
    NanoBOTs to 3D BioBOTs as Future tools
    Rome, Italy
  • Prof. Samuel Sánchez | The Hamelin Symposium on Medical Robotics | 26.06.2019
    Enzyme-powered Nanorobots Towards their Applications in vivo: Enhanced Delivery, Sensing and Imaging
    London, UK
  • Prof. Samuel Sánchez | Plenary talk, Opening Symposium B-Cube | 10.05.2019
    Hybrid nanomotors: bioengineered active nano-systems powered by enzymes
    Dresden, Germany
  • Prof. Samuel Sánchez | University of Tübingen | 07.05.2019
    Active nanoparticles in fluids
    Tübingen, Germany
  • Prof. Samuel Sánchez | Invited ERC-Seminar | 03.05.2019
    Nanobots to 3D BioBots as future tools in robotics and medicine
    Brussels, Belgium
  • Dr. Maria Guix | Seminar at Swiss Federal Laboratories for Materials Science | May 2019
    Thun, Switzerland
  • Rafael Mestre | 1st Cellink Collaborative Partnership | May 2019
    Milan, Italy
  • Prof. Samuel Sánchez | Biennal Ciutat I Ciència, La Pedrera | February 2019
    Nanorobots para nuevas terapias y limpieza de agua
    Barcelona, Spain
  • Prof. Samuel Sánchez | MRS Fall Meeting | 28.11.2018
    Bioengineering hybrid machines: from Nanobots to 3D Biobots
    Boston, USA
  • Dr. Maria Guix | 9 días dimension nano | November 2018
    Organized by Sociedad Catalana de Nanociencia y Nanotecnología honoring the end of Feynman’s year
    Barcelona, Spain
  • Prof. Samuel Sánchez | Keynote talk, NanoBio&Med 2018 | 28.11.2018
    Bioengineering hybrid machines for nanomedicine and soft robotics
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited Seminar, ICMS at TU Eindhoven | 13.09.2018
    Enzyme powered nanomotors from fundamentals to drug delivery
    Eindhoven, Spain
  • Prof. Samuel Sánchez | Keynote talk, London International Youth Science Forum (LIYSF) | 01.08.2018
    Nanorobots as future tools in nanomedicine (and more)
    London, UK
  • Prof. Samuel Sánchez | Invited talk, Columbia University, Molecular Machines Workshop | 28.05.2018
    Engineering Hybrid Machines: from nanobots to 3D BioBots
    New York City, USA
  • Prof. Samuel Sánchez | Invited Seminar, Synthetic Biogoly Lab/Massachusets Institute of Technology | 25.05.2018
    Synthetic multifunctional Nanoswimmers
    Cambridge, USA
  • Prof. Samuel Sánchez | Invited Seminar, Standford Medical School, Molecular Imaging Program at Stanford (MIPS) Department | 01.02.2018
    Artificial Nanoswimmers as future tools in nanomedicine
    San Francisco, USA
  • Prof. Samuel Sánchez | Panel Chair Talk, Aspen School of Physics | January 2018
    Fundamentals of active particles
    Aspen, USA
  • Prof. Samuel Sánchez | Invited Talk, El País con tu futuro/Kinepolis | 21.12.2017
    Nanorobots
    Madrid, Spain
  • Prof. Samuel Sánchez | Plenary talk, Dept. Mat. Sciences, Physical, Organic and Inorganic Chemistry, University of Barcelona | 15.12.2017
    The chemistry and the materials of Micro-/Nano-machines
    Barcelona, Spain
  • Prof. Samuel Sánchez | Keynote talk, II Congreso Nacional de Jóvenes Investigadores en Biomedicina | 23.11.2017
    Nanorobots and their future in NanoBiomedicine
    Valencia, Spain
  • Prof. Samuel Sánchez | Keynote talk, NanoBio&Med 2017| 22.11.2017
    Enzyme Catalysis to Power Nanovehicles Towards Nanomedicine
    Barcelona, Spain
  • Prof. Samuel Sánchez | Keynote talk, Nanomedicie Summer School, Hospital Vall d’Hebron | 29.09.2017
    Hybrid Micro- and Nano-machines towards their applications in Nanomedicine
    Barcelona, Spain
  • Prof. Samuel Sánchez | Keynote talk, Workshop Chem BioNano, CSIC | 14.09.2017
    Biohybrid Robotic Systems: Learning From Nature
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, International Conference on Nano-Micro-Machines | 26.08.2017
    Chemically and Biologically Powered Micromachines
    Wuhan, China
  • Prof. Samuel Sánchez | Invited Seminar, Institut Català d`Investigació Química (ICIQ) | 08.07.2017
    Chemically engineered structures for micromotors
    Tarragona, Spain
  • Prof. Samuel Sánchez | Invited talk, Bojos per la Química | 08.07.2017
    Química en movimiento: Energía química para propulsar NanoRobots
    Tarragona, Spain
  • Prof. Samuel Sánchez | Invited talk, Institut d’Investigació Sanitària Pere Virgili (IISPV) | 07.07.2017
    NanoRobots and their potential applications in biomedicine
    Reus, Spain
  • Prof. Samuel Sánchez | Opening talk, BIYSC, La Pedrera House | 11.07.2017
    Samuel and Nanorobots, a Fantastic Voyage
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited Seminar, Radboud University | 14.06.2017
    Chemically engineered architectures for nanomotors
    Nijmegen, The Netherlands
  • Prof. Samuel Sánchez | Plenary talk, Jornades de Biologia Molecular | 13.06.2017
    Biohybrid Robotic Systems: Learning From Nature
    Barcelona, Spain
  • Prof. Samuel Sánchez | Plenary talk, EChems Conference | 09.06.2017
    Powering tiny particles with catalysis: self-powered nanomachines
    Milano Maritima, Italy
  • Prof. Samuel Sánchez | Keynote talk, Catalan Society of Chemistry | 03.05.2017
    Nanorobots for biomedical and environmental applications
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, International Center for Leadership Development (CEDE) | 05.04.2017
    Experimentando un viaje alucinante
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, Universidad Autónoma Metropolitana (UAM) | 12.12.2016
    Nanomáquinas, ciencia ficción o realidad
    Mexico City, Mexico
  • Prof. Samuel Sánchez | Invited talk, NanoBio&Med 2016 | 22.11.2016
    Chemical Nanomachines as active drug nanovehicles
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, Universitat Pompeu Fabra | 09.11.2016
    Nanomicrorobots what for
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, University of Rome Tor Vergata | 02.11.2016
    Enzyme powered nanomachines: Science fiction or reality
    Rome, Italy
  • Prof. Samuel Sánchez | Opening talk/Master of ceremony. MIT Innovators U35 Awards | 27.10.2016
    Madrid, Spain
  • Prof. Samuel Sánchez | Invited talk, Master of Excelence Awards of Fundació Catalunya-La Pedrera | 06.10.2016
    La ciencia, un viaje alucinante
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, Colloquium at the Royal Academy of Sciences | 22-23.09.2016
    Nanobots: catalysis powered nanoparticles
    Amsterdam, The Netherlands
  • Prof. Samuel Sánchez | Keynote talk, GABBA International Conference 2016 | 15.07.2016
    Nanorobots: smart self-powered nanoparticles towards biomedical applications
    Porto, Portugal
  • Prof. Samuel Sánchez | TED Talk, TEDx Plaça del Fòrum | 28.05.2016
    Nanorobots
    Tarragona, Spain
  • Prof. Samuel Sánchez | Public talk, Caixa Forum | 15.04.2016
    Nanorobots: esos diminutos submarinos que nos ayudarán en el futuro
    Girona, Spain
  • Prof. Samuel Sánchez | Opening Lecture, PhD award ceremony/ Autonomous University of Barcelona | 08.04.2016
    Cómo experimentar un viaje alucinante
    Bellaterra, Spain
  • Prof. Samuel Sánchez | Invited talk, International Course on Leadership Development | 16.03.2016
    Cómo experimentar un viaje alucinante
    Granada, Spain
  • Prof. Samuel Sánchez | Invited Lecture, Award ceremony Joven Relevante | 01.03.2016
    Nano-Robots and Nano-Machines: how small can you dream them?
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, International workshop Soft Matter at interfaces | 27-29.02.2016
    Experiments on active matter at the micro- and nano-scale
    Tegernsee, Germany
  • Prof. Samuel Sánchez | Invited Lecture, GABBA International PhD program | 23.02.2016
    Nanorobots: the future smart tools in medicine?
    Porto, Portugal
  • Prof. Samuel Sánchez | Invited Lecture, Acte premis Catalunya-La Pedrera | 19.02.2016
    Fantastic Voyage: Back where everything started
    Mont Sant Benet, Spain
  • Prof. Samuel Sánchez | Invited Lecture, Círculo Ecuestre de Barcelona | 11.02.2016
    Nanobots Relevantes
    Barcelona, Spain
  • Prof. Samuel Sánchez | Invited talk, Global Robots Expo | 27-19.01.2016
    NanoBots for Medicine and more
    Madrid, Spain
  • Prof. Samuel Sánchez | Invited Seminar, POSTECH/Chemical Engineering Department | 3-4.12.2015
    Engineering small self-powered nano-bio-devices
    Korea, Republic of (South Korea)
  • Prof. Samuel Sánchez | Invited Seminar, POSTECH/Chemical Engineering Department | 1-2.12.2015
    Ultra-compact smart nano-bio-devices for (bio)sensing and nanorobotics
    Korea, Republic of (South Korea)
  • Prof. Samuel Sánchez | Invited Seminar, Gordon Conference Oscillations Instabilities in Chemical Systems | 22-25.09.2015
    Strategies for controlling and guiding catalytic micro-motors
    Stowe, USA
  • Prof. Samuel Sánchez | Invited talk, Summer School Jülich Forschungzentrum | 21.09.2015
    Microswimmers based on tubular micro- and nanojets
    Aachen, USA
  • Prof. Samuel Sánchez | Highlight talk, EUROMAT | 22.09.2015
    Synthesis of chemically powered nanomotors
    Warsaw, Poland
  • Prof. Samuel Sánchez | Keynote Speaker, TNT Conference | 07-11.09.2015
    Nano-bots as future trends in nano-bio-medicine
    Toulouse, France
  • Prof. Samuel Sánchez | Invited Appearance at MIT TR35 Germany representing Spanish innovators U35 | June 2015
    Berlin, France
  • Prof. Samuel Sánchez | Invited talk, Engineering Chemical Complexity | 22.06.2015
    Engineering Chemical Micro-and Nanomotors
    Munich, Germany
  • Prof. Samuel Sánchez | Plenary talk, Jornades Doctorals, Universitat Autònoma de Barcelona | 27.05.2015
    Fantantic Voyage: where everything started
    Bellaterra, Spain
  • Prof. Samuel Sánchez | Invited talk, ZCAM Conference | 22.05.2015
    Active Colloidal micromotors
    Zaragoza, Spain
  • Prof. Samuel Sánchez | Invited talk, TAU-IBEC Symposium | 16.05.2015
    Smart Nano-Bio-Devices
    Barcelona, Spain
  • Prof. Samuel Sánchez | Introductory Speaker, GAFOE Meeting | 15.04.2015
    Potsdam, Spain
  • Prof. Samuel Sánchez | Tutorial Lectures, MRS Tutorial Spring Meeting | 08.04.2015
    Bio-inspired Micro-and Nanomachines
    San Francisco, USA

POSTER AND ORAL CONTRIBUTIONS

  • Carles Prado Morales | ArtBio 2024 | Exploring the Movement of PLGA Nanobots in Human Skin Models | 14-16.08.2024 ​
    Oral and Poster presentation. Aarhus, Denmark
  • Noelia Ruiz-González | CRS 2024: Annual Meeting and Exposition | Swarms of enzyme-powered nanomotors enhance the diffusion of macromolecules in viscous media| 08-12.07.2024 ​
    Poster pitch. Bologna, Italy
  • Meritxell Serra-Casablancas | CRS 2024: Annual Meeting and Exposition | UREASE-POWERED NANOBOTS FOR RADIONUCLIDE BLADDER CANCER THERAPY| 08-12.07.2024 ​
    Oral presentation. Bologna, Italy
  • Meritxell Serra-Casablancas | Nanomotors International Conference 2024 at MUSEO DE LA CIENCIA Cosmo Caixa – Barcelona, organized by Institute for Bioengineering of Catalonia (IBEC) | UREASE-POWERED NANOBOTS FOR RADIONUCLIDE BLADDER CANCER THERAPY| 04.06.2024 ​
    Oral presentation. Barcelona, Spain
  • Noelia Ruiz-González | Nanomotors International Conference 2024 at MUSEO DE LA CIENCIA Cosmo Caixa – Barcelona, organized by Institute for Bioengineering of Catalonia (IBEC) | Swarms of enzyme-powered nanomotors enhance the diffusion of macromolecules in viscous media | 03.06.2024 ​
    Oral presentation. Barcelona, Spain
  • Dr. David Esporrín | Nanomotors International Conference 2024 at MUSEO DE LA CIENCIA Cosmo Caixa – Barcelona, organized by Institute for Bioengineering of Catalonia (IBEC) | Tuning organic nanogels “à la carte” for a new generation of smart nanomotors | 03.06.2024 ​
  • Carles Prado Morales | Nanomotors Internantional Conference – CosmoCaixa | Exploring the Movement of PLGA Nanobots in Human Skin Models | 02-05.06.2024 ​
    Poster presentation. Barcelona, Spain
  • Inés Macías | ICMS Symposium 2024 | TUrease-Powered Drug-Loaded PLGA Nanomotors as a New Approach for Bladder Cancer Therapy​ | 14.03.2024 ​
    Poster presentation. Eindhoven, Netherlands
  • Maria Crespo-Cuadrado | ICMS Symposium 2024 | Tailoring the properties of muscle tissue models using different biofabrications approaches | 14.03.2024 ​
    Poster presentation. Eindhoven, Netherlands
  • Carles Prado Morales | ICONAN 2024 | Designing Enzymatically-Powered PLGA Nanobots and Exploring their Swarming Behavior | 15-17.01.2024 ​
    Poster presentation. Barcelona, Spain
  • Maria Crespo-Cuadrado | BIST Forum 2024 | In representation of our group as receivers of the BIST Ignite Project with TriBioNics Project | 11.01.2024 ​
    Poster presentation. Barcelona, Spain
  • Noelia Ruiz-González | Nanobio&med 2023 Conference | Swarms of enzyme-powered nanomotors enhance the diffusion of macromolecules in viscous media | 21-23.11.2023 ​
    Poster presentation. Barcelona, Spain
  • Maria Crespo-Cuadrado | 3D Bioprinting Iberian Workshop 2023 (3BIW) | 3D Bioprinting of Skeletal Muscle Actuators | 28-29.11.2023 ​
    Oral presentation. Coimbra, Portugal
  • Carles Prado Morales | Nanobio&med 2023 Conference | Designing Enzymatically-Powered PLGA Nanobots and Exploring its Swarming Behavior and Oil Interface Intercation | 21-23.11.2023 ​
    Poster presentation. Barcelona, Spain
  • Judith Fuentes | MARSS, Abu Dhabi, October 2023, Organized by NYUAD | Integration of ferrofluid into 3D bioprinted skeletal muscle-based actuators provides magnetic guidance and improves contraction force | 09-13.10.2023 ​
    Oral presentation. Abu Dhabi
    , United Arab Emirates
  • Noelia Ruiz-González | 16th IBEC Symposium: Bioengineering for Future and Precision Medicine | Swarms of enzyme-powered nanomotors enhance the diffusion of macromolecules in viscous media | 03.10.2023 ​
    Poster presentation. Barcelona, Spain
  • Meritxell Serra-Casablancas | 16th IBEC Symposium: Bioengineering for Future and Precision Medicine | Radionuclide therapy with accumulated urease-powered nanobots reduces bladder tumor size in an orthotopic murine model | 03.10.2023 ​
    Oral presentation. Barcelona, Spain
  • Meritxell Serra-Casablancas | CRS Italy Local Chapter 2023 -NEXT GENERATION BIOMATERIALS AND CARRIERS: NEW TOOLS FOR DRUG DELIVERY AND THERAPY | Radionuclide therapy with accumulated nanobots reduces bladder tumor size in vivo | 05-07.10.2023 ​
    Poster presentation. Palermo, Italy
  • Judith Fuentes | Workshop at Living Machines 2023 – Biohybrid actuators and enabling technologies: step-by-step towards futuristic machines, Genova Italy, organized by BIOMELD partners | Development of 3D bioengineered skeletal muscle-based biohybrid actuators| 10-13.07.2023 ​
    Oral presentation. Genova, Italy
  • Noelia Ruiz-González | Workshop on Active Matter at Surfaces and in Complex Environments, Max Planck Institute for the Physics of Complex Systems | Swarms of enzyme-powered nanomotors enhance the diffusion of macromolecules in viscous media| 19-23.06.2023 ​
    Poster presentation. Dresden, Germany
  • Judith Fuentes | Molecular Systems Engineering for Bioapplications – Germany, Organized by the University of Heidelberg | Co-axial 3D bioprinting for Biomimetic Multifiber Skeletal Muscle-based Bioactuators | 19-21.10.2022 ​
    Poster presentation. Heidelberg, Germany
  • Judith Fuentes | EMBL-IBEC Winter Conference, Engineering multicellular systems | Co-axial 3D bioprinting for Biomimetic Multifiber Skeletal Muscle-based Bioactuators | June 2022 ​
    Poster presentation. Barcelona, Spain
  • Dr. Maria Guix | Workshop for Early-Career Researchers at EMBL Barcelona, organized by EMBL Barcelona | Biohybrid soft robots with self-stimulating skeletons | 23.06.2021
    Oral presentation. Online Workshop
  • Dr. Maria Guix | Workshop on Multicellular Engineered Living Systems (M-CELS), organized by MIT | Smart training of 3D engineered living robots | 02.06.2021
    Poster presentation. Online Workshop
  • Dr. Maria Guix | Nanorobots for Biotechnology, Nature Conference | 3D printed living robots with self-stimulating skeletons | 26.05.2021
    Oral presentation. Online Conference
  • Xavier Arqué | IBEC PhD Discussions | April 2021
    Oral presentation. Online seminar
  • Xavier Arqué | 13th IBEC Symposium, Bioengineering for Future & Precision Medicine | October 2020
    Poster contribution. Online conference
  • Ana C. Hortelão | 13th IBEC Symposium, Bioengineering for Future & Precision Medicine | October 2020
    Poster contribution. Online conference
  • Dr. Veronika Magdanz | 13th IBEC Symposium, Bioengineering for Future & Precision Medicine | October 2020
    Video contest and poster contribution. Online conference
  • Dr. Maria Guix | 13th IBEC Symposium, Bioengineering for Future & Precision Medicine | October 2020Smart skeletons for 3D printed living biobots​
    Online Symposium – 
    Best flash presentation
  • Dr. Veronika Magdanz | NanoBio&Med Online | July 2020
    Oral contribution. Online Conference
  • Dr. Maria Guix | NanoBio&Med Online | July 2020
    Oral contribution. Online Conference
  • Dr. Maria Guix | NanoBio&Med | November 2019
    Oral contribution. Barcelona, Spain
  • Xavier Arqué | International Workshop – Microscale Motion and Light | July 2019
    Poster contribution. Dresden, Germany
  • Rafael Mestre | 8th Living Machines Conference | July 2019
    Oral contribution. Osaka, Japan
  • Rafael Mestre | NanoBio&Med | November 2018
    Oral contribution. Barcelona, Spain
  • Xavier Arqué | NanoBio&Med | November 2019
    Oral contribution. Barcelona, Spain 
  • Xavier Arqué | Workshop on Molecules, Materials, Devices and Systems in Medicine | May 2018
    Poster contribution. New York City, USA
  • Xavier Arqué | NanoBio&Med | November 2017
    Poster contribution. Barcelona, Spain 

HIGHLIGHTS

Outreach activities

16-18/10/2024 | 57th Urology Course by Fundació Puigvert in Barcelona

Last October, from the 16th to the 18th, the 57th Urology Course was held in Barcelona, organized by the Fundació Puigvert.

More than 650 specialists attended the course, both in person and virtually, to exchange ideas and learn about the technological and scientific advancements in Urology, guided by leading experts in various fields of the specialty. “I believe we achieved this goal,” remarked Dr. J. Palou, Director of the Urology Service.

On behalf of the entire Urology Service and the Fundació Puigvert, Dr. Palou expressed his gratitude for Samuel Sánchez’s participation in the course, stating that it had been a true pleasure to have his collaboration and contributions.


16-18/09/2024 | Annual Seminars and Group Retreat 2024

Annual seminars for group members were held, where they presented results from ongoing projects. Brainstorming sessions allowed senior group members to propose new projects that could foster the growth and advancement of both the group and current projects. During these sessions, all group members contributed feedback and ideas to the proposals presented. Additionally, there were talks by two invited professors from Korea: Tae-Eun Park and Jonathan Sabtè del Rio. Various social activities were also organized.

Ainhoa González | PhD Student
Anna García | PhD Student
Florencia Lezcano | Post-Doc Researcher
Inés Macías | PhD Student
Kristin Fichna | PhD Student
Shuqin Chen | PhD Student
Carles Prado | PhD Student
Daniel Sánchez | Post-Doc Researcher
Jinwei Lin | PhD Student
Juan Fraire | Senior Researcher
María Crespo | Post-Doc Researcher
David Esporrín | Post-Doc Researcher
Noelia Ruiz | PhD Student
Judith Fuentes | PhD Student
Tae Eun Park | Invited Talk
Jonathan Sabtè del Rio | Invited Talk

14-16/08/2024 | ArtBio2024 – 2nd Artificial Biology: Assemble – Imitate – Adapt in Aarhus (Denmark)

Samuel Sánchez and Carles Prado attended the ARTBIO 2024 conference held at Aarhus University. The event brought together leading experts different themes and topics that represent the fast-evolving field and illustrate the diversity of Artificial Biology as a discipline, offering a unique platform for interdisciplinary collaboration. Sánchez and Prado contributed with their knowledge in nanomotors and some research conducted in the area of skin.

Samuel Sánchez
Carles Prado

08-12/07/2024 | CRS 2024 Annual Meeting and Expo in Bologna (Italy)

Members of our group, including Juan Fraire, Noelia Ruiz, Meritxell Serra, Inés Macias, and Ainhoa González, attended the CRS 2024 Annual Meeting and Expo, held from July 8-12 in Bologna, Italy. This year’s conference, themed “Integrating Delivery Science Across Disciplines,” focused on the integration of various fields such as pharmaceutical sciences, engineering, biotechnology, materials science, and chemistry to advance delivery sciences and improve patient care. The event featured presentations on nanomedicine, imaging, and artificial intelligence, among others, and provided opportunities for networking and collaboration among professionals from academia, industry, and regulatory agencies.


10/07/2024 | Presentation of Anna Pushkareva’s Master’s Thesis

On July 10th, Anna Pushkareva presented her master’s thesis titled “Analysis of Collective Behavior in PLGA and SiO2 Nanomotors through their Covered Area: A Computer Vision Approach,” under the supervision of Samuel Sánchez and co-supervision of Florencia Lezcano.

This thesis aims to analyze the collective behaviour of PLGA and silica nanomotors by enhancing the analytical capabilities of custom-made software. The specific objectives are to integrate computer vision techniques into existing arithmetic-based software to analyze a broader range of spherical nanomotors, validate the new tool using simulated videos with known parameters, synthesize PLGA and SiO2 nanomotors, and compare their behaviour using videos recorded with the Leica THUNDER Imaging System.



20/06/2024 | Florencia Lezcano Highlights Bioprinting Advances at 3D Bioprinting Course

Florencia Lezcano was invited to present at the 3D Bioprinting Course (Bioimpresión 3D: Tecnología Emergente en la Frontera entre la Biomedicina y la Ingeniería (4ª edición) from June 18 to June 21, in Santiago de Compostela. Her presentation, “Overcoming Challenges of Bioprinting Tissue Models Using Python-based GCode Designer,” addressed the significant hurdles in bioprinting tissue models and showcased the innovative use of Python-based GCode designer tools to enhance the bioprinting process. The course provided a platform for experts, students, and researchers ranging from high schoolers to PhD candidates and senior investigators to share advancements and collaborate on cutting-edge bioprinting technologies.


03/06/2024 | Oral presentations by some members of our group at the Nanomotors International Conference 2024

Meritxell Serra-Casablancas presented her research titled ‘Urease-Powered Nanobots for Radionuclide Bladder Cancer Therapy,’ at the Nanomotors International Conference. Where she highlighted the significant reduction of bladder tumors by up to 90% in mice using urea-powered nanobots. With this presentation, she won the award for Best Short Talk on Nanomotors for Biomedicine.

Samuel Sánchez presenting the award for Short Talk on Nanomotors for Biomedicine to Meritxell Serra Casablancas

Noelia Ruiz- González presented groundbreaking research on enzyme-powered nanomotors. Her work show that swarms of these nanomotors significantly enhance the diffusion of macromolecules in viscous media. This advancement has the potential to revolutionize the field by improving the efficiency of drug delivery systems and other biomedical applications.

David Esporrín presented on the topic of “Tuning organic nanogels ‘à la carte’ for a new generation of smart nanomotors” at the Nanomotors International Conference. His presentation focused on the customization of organic nanogels to enhance the performance and functionality of nanomotors, potentially revolutionizing their applications in various fields such as medicine and technology.


02-05/06/2024| The Nanomotors International Conference: 20th Anniversary

Last week, Barcelona was the epicenter of cutting-edge scientific innovation, hosting the Nanomotors International Conference. Organized by Samuel Sánchez, Florencia Lezcano, and the communications department of the Institute for Bioengineering of Catalonia (IBEC), the event celebrated two decades of groundbreaking research in nanorobotics. The conference was held in collaboration with the “la Caixa” Foundation, the Catalunya La Pedrera Foundation, and the European Research Council (ERC).

From June 2 to 5, the conference brought together top scientists and researchers from around the globe to discuss the latest advancements in nanomotor technology.

After the opening of the event, Samuel Sánchez presented a commemorative award to Wally Paxton and Ayusman Sen. They were two of the authors of a pioneering study published in 2004 in the scientific journal Journal of the American Chemical Society, which described the autonomous movement of nanoparticles through a catalytic reaction.

Throughout the entire event keynote speeches, panel discussions, and presentations covered a wide range of topics, including the design and application of nanomotors in medical treatments, environmental monitoring, and diagnostics.

Attendees were particularly excited about the potential of nanomotors for targeted drug delivery and non-invasive medical procedures, which promise to revolutionize healthcare.

As the conference concluded, it set the stage for future breakthroughs, highlighting the pivotal role of nanomotors in transforming medicine and environmental science.

Samuel Sánchez presented a commemorative award to Wally Paxton and Ayusman Sen.

Samuel Sánchez‘s opening presentation

Parallel session: Combining nanocarrier design and self-propulsion for delivery of nucleic acids
Juan Fraire (IBEC)

Poster session: Ainhoa González (IBEC)

Maria López (IBEC)

Parallel session: Swarms of enzyme-powered nanomotors enhance the diffusion of macromolecules in viscous media,
Noelia Ruiz González (IBEC

Award for the Best Postdoctoral Talk: Yufen Chen (Institute of Chemical Research of Catalonia – ICIQ)

Award for Best Short Talk on Motion Control: Enrique Solano Rodríguez (UAH)

Award for Best Short Talk on Nanomotors for Biomedicine: Meritxell Serra Casablancas (IBEC)

Opening Event – Some Members of the Smart Nano-Bio-Devices Group



12-16/05/2024 | ECI Conference Nanotechnology in Medicine IV: Physical Triggers and Advanced Materials for Translation

Juan Fraire attended the #ECI conference from May 12-16 in Tomar, Portugal. The conference built on the successes of the four previous ECI meetings on nanotechnology in medicine to highlight advances and the translation of physical triggers and advanced materials in translational nanomedicine, focusing on areas such as advanced drug delivery, advanced imaging, immunoengineering, surgery and tissue repair, biofabrication of tissue models, nano-bio interactions, translational nanotechnologies, and a special session on Justice, Equity, Diversity, and Inclusion.


21-23/11/2023 | Poster contribution by Noelia Ruiz-González and Meritxell Serra-Casablancas at NanoBio&Med 2023, Barcelona, Spain

Noelia Ruiz-González presented a poster at theNanoBio&Med2023 conference, Detailing part of her research work. The conference, held in Barcelona, focused on the latest advancements in nanobiotechnology and nanomedicine, providing a platform for interdisciplinary collaboration between academia and industry.

Ruiz-González’s poster highlighted her significant contributions to the field, emphasizing the potential of her work to impact future developments in nanomedicine.

The event fostered discussions on emerging trends and challenges, promoting new partnerships and projects aimed at advancing the convergence of nanotechnology, biotechnology, and medicine.

Meritxell Serra-Casablancas
Noelia Ruiz-González

From our group, Meritxell Serra-Casablancas also attended the event and presented the poster: titled “Radionuclide therapy with accumulated nanobots reduces bladder tumor size in vivo.” This research highlighted the significant reduction of bladder tumors by up to 90% in mice using urea-powered nanobots. These nanobots, designed to self-propel within the bladder, accumulate at the tumor site and enhance the efficacy of the radiopharmaceuticals due to their ability to break down the extracellular matrix of the tumor, facilitating deeper penetration.

These promising results could lead to innovative bladder cancer treatments. These treatments aim to reduce hospitalization time and improve patient outcomes by targeting tumors more effectively with localized radionuclide therapy.


09-13/10/2023| MARSS 2023 – International Conference on Manipulation, Automation and Robotics at Small Scales at the New York University of Abu Dhhabi (NYUAD)

Judith Fuentes Llanos, Shuqin Chen and Samuel Sánchez Ordóñez attended MARSS 2023, the International Conference on Manipulation, Automation and Robotics at Small Scales. It was run by the microrobotic community and technically supported by IEEE-RAS and IEEE-NTC, and it was held at New York University Abu Dhabi (NYUAD).

During the Conference, Judith held a talk providing a more detailed insight into the work done in collaboration with Veronika Magdanz from University of Waterloo, Zoran Cenev from Aalto University, Maria Guix from Universitat de Barcelona, and Anna C. Bakenecker from Fraunhofer IMTE. The project focuses on the integration of ferrofluid into 3D bioprinted skeletal muscle-actuators, developing a so called ferromuscle. The team observed that the addition of the ferrofluid into the 3D printable bioink allowed them to fabricate muscle bioactuators that can be magnetically manipulated, that is, their directionality and motion can be controlled by the magnetic field. Also, they observed that the integration of this ferrofluid improved the contraction force of the ferromuscle threefold compared to the control muscle (without the ferrofluid). Their work continues, and the results are very promising.


03/10/2023| 16th IBEC Symposium: Bioengineering for Future and Precision Medicine

At the 16th IBEC Symposium: Bioengineering for Future and Precision Medicine, held in Barcelona on October 3rd, 2023, Meritxell Serra-Casablancas presented her groundbreaking research titled “Radionuclide Therapy with Accumulated Urease-Powered Nanobots Reduces Bladder Tumor Size in an Orthotopic Murine Model.” The event, organized by the Institute for Bioengineering of Catalonia (IBEC), brought together leading experts in bioengineering and precision medicine to discuss the latest advancements and future directions in the field. Meritxell’s presentation highlighted the innovative use of urease-powered nanobots in radionuclide therapy, showcasing significant reductions in bladder tumor size in experimental murine models, thus offering promising insights for future cancer treatments.


31/05/2023| BLADDEBOTS nanobots reach the classroom through the Nanoinventum dissemination initiative

BLADDEBOTS is a research project from Fundación «la Caixa» led by Samuel Sánchez focused on the design of nanobots for the treatment of bladder cancer. With the aim of transmitting BLADDEBOTS research to society, Samuel Sánchez has collaborated with the Nanoinventum dissemination initiative, which brings nanotechnology closer to primary school classroom.

Using educational resources and creativity tools, the boys and girls participating in Nanoinventum designed nanobots to solve current problems related to the sustainability challenges of the 2030 agenda.

This year’s edition ended with a closing ceremony held at the Molins de Rei Municipal Sports Center on May 31, which was attended by more than 700 students from different schools throughout Catalonia. There, nearly 300 nanorobot models were presented to the jury. 

#nanorobots challenge: All these kids building their #nanorobots great initiative by @nanoinventum
at #molinsderei. #outreach ideas from the project Bladdebots from @CaixaResearch
@IBECBarcelona

Credit: Universitat de Barcelona

10/02/2023| Meritxell Serra-Casablancas participates in the “100tífiques” programme during the International Day of Women and Girls in Science

During the International Day of Women and Girls in Science, Meritxell gave a talk to high school students from IE Sant Esteve (Castellar del Vallès) about her motivation to become a scientist and her day-to-day work in the lab, as part of the 100tífiques program (Fundació Catalana per a la Recerca i la Innovació). They shared a great discussion about science and the future of nanobots.

https://agora.xtec.cat/ceip-santesteve/bloc-1r-deso-22-23/apropem-la-ciencia/

12-14/12/2022 | Group’s Annual Seminar

We had our group seminars (an internal scientific workshop) with lots of new and unpublished results open for discussions, brainstorming sessions, creative thinking and outstanding talks!

Day 1 opened the workshop with a Team brainstorming session pointing out the challenges and goals for 2023 in the field of nanomotors for (1) fundamental undertanding of nanobots and (2) biomedical applications. Many things in our minds, many ideas. Now it is time to tackle the challenges and go for it!

Day 2 was fully packed with seminars and discussions, with feedback from Samuel. Luckily we had some break for lunch! 😊

Day 3 brought us the Biobots and Bioactuators, becuase not everything is nano in the group!


October-December 2022 |BLADDEBOTS Internship programme for undergraduate students

Undergraduate students, Jaume Ros Miralles and Filotea Crasovan Neacsu, performed an internship in the group within the Bladdebots project (CaixaHealth) under the supervision of Dr. Valerio Di Carlo, PhD student Meritxell Serra-Casablancas and Dr. Juan Fraire.


30/09/2022. Meritxell Serra-Casablancas gave a talk in the European Research Night 2022 (CosmoCaixa)

Researcher Meritxell Serra-Casablancas participated in the European Research Night 2022, where she gave a talk about the work conducted at the Smart Nano-bio-devices group, in which nanobots are used to treat bladder cancer. It was a delightful opportunity to share our latest scientific breakthroughs.


05/08/2022| Marc Canadell, from the “Joves i Ciència” Program, joined the Smart Nano-bio-devices Group for a research stay

The student Marc Canadell joined the group for a research stay within the “Joves i Ciència” program from Fundació Catalunya La Pedrera, under the supervision of Dr. Valerio Di Carlo and PhD student Meritxell Serra-Casablancas. 


01/03/2022 | Meritxell Serra-Casablancas, Nanoexpert at Escola Lavínia

Meritxell Serra-Casablancas visited Escola Lavínia de Barcelona, as a Nanoexpert to talk about Nanomedicine with the students of the last grade of elementary school.  The students shared with her their nanobot designs to present them to the Nanoinventum contest. They also brainstormed some ideas to be applied into the field of biomedicine. 

Noelia Ruiz González a l’Escola Enric Granados

15/12/2021 | Visit at Natura Encesa at Pedralbes

Some of the group members were gathering at the Nature Encesa immersive experience at the Pedralbes gardens. Collective motion is everywhere if you carefully look at it!


12/11/2021 | Prof. Samuel Sánchez visits POSTECH in Korea

During his trip to Korea, Prof. Sánchez visited the IBS Center for Nanomedicine, he visited POSTECH. It was definitely a great experience to discuss science and discover korean culture!


30/07/2021 | Dr. Maria Guix, invited speaker and round table at the workshop “Biohybrid robotics”, organized in the frameword of the Living Machines 2021

Dr. Maria Guix participated as an invited speaker and the round talbe of the Biohybrid Robotics Workshop organized in the framework of the International Living Machines 2021, being online due to the current COVID situation and which celebrates its 10th anniversary.


15/07/2021 | Laia Marcos Canal participates at the tribute to COVID victims, organized by Casa Real and Moncloa

Laia Marcos Canal, former Batx2Lab student supervised by Dr. Maria Guix, participated in a short video partly recorded at IBEC that was released during the tribute to COVID victims, in which differents personal situation during the pandemic were reflected. Laia was chosen for obtaining the best mark at the selectivity and participating at research related programs, like the BATX2LAB one.

* Check minutes: 35:20 – 38:27


11/06/2021 | Bienal Ciudad y Ciencia, Dissemination activity “Pecha Kucha express: art, science, technology”

Prof. Samuel Sánchez participated in the dissembination activity Pecha Kucha express in the framework of the Biennal Ciudad and Science, organized by the Barcelona city council. This successful event was followed in-person in an open space concept in Plaça Comercial in Barcelona.


03/06/2021 | Prof.  Jingyao Tang, Guest Scientist at NBS Journal Club

Prof. Jinyao Tang, currently an Associate Professor in the Department of Chemistry at the University of Hong Kong, participated in our NBS Journal Club as a guest scientist to discuss from the electrokinetic effect in microswimmers swarms, a Journal club session hosted by Xavi Arqué and Ana Hortelao. We really enjoyed the discussion with Prof. Tang, and we are looking forward to keep in touch with his group!


24/05/2021 | Dr. Maria Guix, Talk at the MultiScale Talk Series, organized by Dr. Zoran Cenev (Aalto University)

Self-stimulating skeletons for living robotics platforms


10/05/2021 | Dr. Veronika Magdanz, Talk at the MultiScale Talk Series, organized by Dr. Zoran Cenev (Aalto University)

Biohybrid microbots – What Sperm can teach us about microrobotics


01/05/2021 | Meritxell Serra-Casablancas, Nanoinventum contest evaluator

Predoctoral researcher Meritxell Serra-Casablancas participated as a membre of the jury of the  Nanoinventum contest. The 500 participants created almost 100 nanorobot models to tackle the Sustainable Development Goals (SDGs) of the UN’s 2030 Agenda. All the proposals were really innovative. Good job and congratulations to the winning models: “Nanoabella” (Escola Milà i Fontanals) and “Electrobio” (Escola Lavínia)! 


28/04/2021 | Prof.  Islam S. M. Khalil, Guest Scientist at NBS Journal Club

Prof. Islam S. M. Khalil, currently an Assistant Professor in the Department of Biomechanical Engineering at the University of Twente, participated in our NBS Journal Club as a guest scientist to discuss from the sensing capabilities of magnetotactic bacteria to the automation of helical-like motors for thrombosis treatment. Also, he briefly told us about his current research collaboration with the group member Dr. Veronika Magdanz. Thanks for you insightful talk and discussion Prof. Khalil, we are really looking forward to have you visting us in Barcelona soon!


29/03/2021 | Prof. Samuel Sánchez

Prof. Samuel Sánchez gave a talk at the Escoles del Pallars over the nanomotors impact in ours lives, entitled “Com els Nanorobots milloraran la nostra qualitat de vida”.


26/02/2021 | Dr. Veronica Iacovacci, Guest Scientist at NBS Journal Club

Dr. Veronika Iacovacci, currently a Marie Curie Global Fellow jointly at The Chinese University of Hong Kong and Scuola Superiore Sant’Anna, joined us for the NBS Journal Club as a guest scientist to discuss about her previous and current work on SPECT Imaging with soft microrobots and the design of magnetic catheter. We really appreciate the time she spent with us and the fruitful discussion!


18/02/2021 | Prof. Samuel Sánchez | ERC Workshop

Prof. Samuel Sánchez co-organized the online ERC Workshop “Crafting a Winning ERC Proposal: A Workshop with ERC officers and grantees” and gave a talk on initial general tips, covering the myths, worries and fears and how to choose the right panel.


11/02/2021 | Dr. Maria Guix | 100tifiques

Virtual talk at the School Germans Corbella (Cardedeu)
in the framework of the 100tifiques event.


21/01/2021 | Dr.  Toni Llopis and Dr. Loai Abdelmohsen, Guest Scientist at NBS Journal Club

Dr. Toni Llopis and Dr. Loai Abdelmohsen, researchers at the University of Twente kindly shared some time with us, discussing over some of his papers and also presenting a piece of their recent research work on artificial cells and communication between them and living entities, in order to develop personalized therapeutic treatments. We really appreciate their time and we thank them for the fruitful discussions!


04/12/2020 | Prof.  Victoria Webster-Wood, Guest Scientist at NBS Journal Club

Prof. Victoria Webster-Wood, Assistan Professor from the Carnegie Mellon University (USA) kindly shared her latest research results and accepted our invitation to our Journal Club. We discussed over bio-robotics while discussing three relevant papers from her group presented by Veronika and Judith. We really enjoyed the JC and having her virtually in our lab!


05/11/2020 | Prof. Wei Wang, Guest Scientist at NBS Journal Club

Prof. Wei Wang, from Harbin Institute of Technology (Shenzhen) kindly accepted our invitation to our Journal Club, in order to first discuss two relevant papers from his group to our research, and later present his latest results in the same session. We really appreciate his time and and his insightful presentation!


28/10/2020 | Dr. Maria Guix | 13th IBEC Symposium 

Dr. Maria Guix wins IBEC Symposium Award for the best flash presentation!


26/09/2020 | Rafael Mestre /Xavier Arqué / Dr. Maria Guix | Bojos i boges per la Bioenginyeria 2020

Session: Internalization of Nanomotors by cancer and non-cancer cells


September 2020 |  Dr. Maria Guix | Batx2Lab program

Supervision of Sara González (Institut Jaume Almera, Vilassar de Dalt) during the short internship stay in the framework of Batx2Lab Program for the research work “La medecina regenerativa i les cèl·lules mare”, where she explored the creation of 3D printed muscles as models for personalized medicine. Dr. Maria Demestre taugh Sara about the insights of fluorescent microscopy and how it is apply to characterize skeletal muscle structure!


04/05/2020 | Samuel Sánchez | IBEC Online Seminar 

BioEngineering Hybrid Robotic Machines: from nanobots to 3D Bioprinted Robots


07/03/2020 | Rafael Mestre /Xavier Arqué / Dr. Maria Guix | Bojos i boges per la Bioenginyeria 2020

Session: Internalization of Nanomotors by cancer and non-cancer cells


11/02/2020 | Dr. Maria Guix | 100tifiques

Talk at the School Puig-Agut in Manlleu


27/10/2019 | Xavier Arqué | Participation at “13a Festa de la Ciència”

Moll de la Fusta of Barcelona


July 2019 | Dr. Maria Guix | Batx2Lab program

Supervision of Laia Marcos (Institut Puig Castellar) during the short internship stay in the framework of Batx2Lab Program for the research work “Impressió 3D d’un dit bionic basat en cèl·lules musculars”


05/04/2019 | Prof. Samuel Sánchez | Plenary Talk at Ateneu Maó


04/04/2019 | Prof. Samuel Sánchez | Talk at High School center “Duc de Montblanc”


22/02/2019 | Dr. Maria Guix | 100tifiques

Talk at the School Escola Lluçanès in Prats de Lluçanès


09/02/2019 | Rafael Mestre | Biennal Ciutat i Ciència de Barcelona (La Pedrera)

Taller “Què és la Nanoescala i com ens afecta”


2019-2020 | Rafael Mestre/ Dr. Tania Patiño / Xavier Aqrué | Magnet program for educational innovation

In collaboration with the Fundació Biofill and Escola Gayarre


7/11/2018 and 21/11/2018 | Xavier Arqué | Workshops “Taller de la célula” at IBEC


07/11/2018 | Prof. Samuel Sánchez | Plenary talk at Setmana de la ciència

Teatre La Sala de Rubí


2017-2019 | Rafael Mestre | Workshops “Taller de liberación de fármacos” at IBEC


2019 | Dr. Tania Patiño / Rafa Mestre | Bojos i boges per la Bioenginyeria 2019

Session: Internalization of Nanomotors by cancer and non-cancer cells


December 2017 | Prof. Samuel Sánchez | El Pais con tu Futuro

Keynote and speach corner. El País, Madrid


Top 10% downloaded papers: “Force Modulation and Adaptability of 3D‐Bioprinted Biological Actuators Based on Skeletal Muscle Tissue”

Advanced Materials Technologies (2019) 4, (2), 1800631
Find more information here


Awards


 

  • Dr. Maria Guix | IBEC Symposium Award for the best flash presentation | 28.10.20
    13th IBEC Symposium, Online Symposium
  • Dr. Maria Guix | Beatriu de Pinós Fellowship (Marie Curie COFUND Programme) | February 2020
  • Xavier Arqué | 4th prize poster award | July 2019
    International Workshop Microscale Motion and Light. Dresden, Germany
  • Rafael Mestre | 2nd prize talk award | July 2019
    8th Living Machines Conference. Osaka, Japan
  • Dr. Maria Guix | Awarded BIST-IGNITE Collaborative Project with ICN2 | March 2019
    Project: ElectroSensBioBots: Towards a new generation of programable 3D printed living biobots with nanoelectronics for sensing and local stimulation
  • Dr. Tania Patiño | Awarded BIST-IGNITE Collaborative Project with ICN2 | March 2019
    Project: MOFtors: Enzyme-powered, metal-organic framework based motors
  • Prof. Samuel Sánchez | ERC Consolidator Grant 2019 by the Europen Research Council | 2019
  • Jemish Parmar | Awarded Premi Pioner from CERCA | December 2018
    Doctoral thesis: “Micromotors for Environmental Applications”. See more information here
  • Xavier Arqué | 1st prize poster award | October 2018
    11th IBEC Annual Symposium. Barcelona, Spain
  • Rafael Mestre | 1st prize poster award | July 2018
    7th Living Machines Conference. Paris, France
  • Xavier Arqué | IBEC International PhD Programme fellowship | June 2018
  • Dr. Maria Guix | Juan de la Cierva Incorporación Fellowship | May 2018
  • Prof. Samuel Sánchez | Best Poster Award at MRS Fall Meeting (Science Robotics,USA) | 2018
  • Xavier Arqué | 1st prize talk award | December 2017
    2nd Biomed PhD Day Symposium. Barcelona, Spain
  • Rafael Mestre | 1st prize poster award | November 2017
    NanoBio&Med Conference. Barcelona, Spain
  • Prof. Samuel Sánchez | ERC Proof-of-Concept Grant “Lab-in-a-Patch”/ European Research Council | 2017
  • Prof. Samuel Sánchez | Best Poster Award at Micro-Nanomachines International Conference (Wuhan, China) | 2017
  • Prof. Samuel Sánchez | Guinness ® World Record for the smallest tubular jet of the world | 2017
  • Prof. Samuel Sánchez | National Research Award Young Talent from Catalan Foundation for Research and Innovation | 2016
  • Prof. Samuel Sánchez | Relevant Young Person for the Society by Círculo Ecuestre Barcelona (Spain) | 2016
  • Prof. Samuel Sánchez | ERC Proof-of-Concept Grant “MICROCLEANERS” (European Research Council) | 2016
  • Prof. Samuel Sánchez | TEDx Talk at Plaça del Fórum (Tarragona) |2016
  • Prof. Samuel Sánchez | Innovator Under30 Europe/ Ambassador and representative at EU Parliament/EU Summit  | 2015
  • Prof. Samuel Sánchez | Princess of Girona Scientific Award (Princess of Girona Foundation/Spain) | 2015
  • Prof. Samuel Sánchez | Selected Emerging Investigators Special Issue by Chem Communications Journal | 2015
  • Prof. Samuel Sánchez | Future Leaders in Nano-architectonics at Sci.Tech.Adv.Mater. Journal | 2015
  • Prof. Samuel Sánchez | Innovator of the year and Top 10 Spanish Innovator under 35/MIT Technology Review | 2014
  • Prof. Samuel Sánchez | Full Fellowship for Nobel Laureate Meeting-Chemistry by VW Foundation (Germany) | 2013
  • Prof. Samuel Sánchez | Best poster Award/1st Herrenhäuser conference “Downscaling Science” at VW Foundation (Germany) | 2013
  • Prof. Samuel Sánchez | ERC Starting Grant 2012 by European Research Council | 2012
  • Prof. Samuel Sánchez | IFW-IIN Research Prize as outstanding scientist/Leibniz Institute for Solid State and Materials Research Dresden (IFW)/Germany | 2011
  • Prof. Samuel Sánchez | Guinness World Record ® for the “Smallest Man-Made Jet Engine” | 2010

Covers

Nano Letters
01/02/2019

Patiño, Tania, Porchetta, Alessandro, Jannasch, Anita, Lladó, Anna, Stumpp, Tom, Schäffer, Erik, Ricci, Francesco, Sánchez, Samuel, (2019). Self-sensing enzyme-powered micromotors equipped with pH-responsive DNA nanoswitches Nano Letters 19, (6), 3440-3447

Journal of the American Chemical Society
22/05/2018

Patiño, Tania, Feiner-Gracia, Natalia, Arqué, Xavier, Miguel-López, Albert, Jannasch, Anita, Stumpp, Tom, Schäffer, Erik, Albertazzi, Lorenzo, Sánchez, Samuel, (2018). Influence of enzyme quantity and distribution on the self-propulsion of non-Janus urease-powered micromotors Journal of the American Chemical Society 140, (25), 7896-7903

Applied Materials Today
16/01/2018

Romeo, Agostino, Moya, Ana, Leung, Tammy S., Gabriel, Gemma, Villa, Rosa, Sánchez, Samuel, (2018). Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis Applied Materials Today 10, 133-141

acscoversamuel2016ACS Nano
25/10/2016

Xing Ma, Ana C. Hortelão, Tania Patiño, and Samuel Sánchez (2016). Enzyme Catalysis To Power Micro/Nanomachines. ACS Nano, Volume 10, Issue 10, pp. 9053–9762

 
ami cover-samuelAdvanced Materials Interfaces
21/01/2016

Morgan M. Stanton, Juliane Simmchen, Xing Ma, Albert Miguel-López, Samuel Sánchez* (2015). Bio-hybrid Janus Motors Driven by Escherichia coli. Adv Mat Interfaces

 
small cover samuelSmall
09/10/2015

Xing Ma, Jaideep Katuri, Yongfei Zeng, Yanli Zhao and Samuel Sanchez (2015). Janus Micromotors: Surface Conductive Graphene-Wrapped Micromotors Exhibiting Enhanced Motion. Small, 11, 38, p4989