Targeted drug delivery: fundamental aspects and translational applications
Silvia Muro, IBEC
The design of strategies to enable efficient and safe delivery of therapeutic agents to areas of the body requiring intervention is an active research field. Therapeutic targets are often confined to specific regions or tissues in the body, where access may require active transport from the administration site into a subjacent or far-away tissue. Once within the tissue or body compartment of interest, most targets for therapeutic intervention relate to particular sub-cellular environments, e.g., the cell surface versus different intracellular compartments, requiring strategies to achieve the final destination of interest. Using polymer nanocarriers functionalized with affinity moieties against single or combined cell-surface receptors, along with additional biological signaling moieties, my laboratory focuses on understanding the parameters that regulate transport of drug delivery vehicles across cellular barriers and/or into compartments of subjacent tissues. We examine these aspects using cell culture models with subsequent validation in laboratory animals to correlate molecular/cellular mechanisms with in vivo outcomes. We investigate the influence exerted on targeting and transport by drug carrier design parameters (size, shape, avidity, combination targeting, etc.) and parameters that are intrinsic to the physiological system (disease states, flow, receptor epitopes being targeted, modulation of regulatory molecules, etc.).
In this presentation, I will focus on reviewing some of our most recent efforts in this field. The characterization of these complex physiological and design parameters, along with the understanding of the mechanisms governing the interaction of drugs carriers with the surrounding biological environment, are necessary steps toward achieving efficient drug delivery systems.
This seminar will take place online at the GoToMeeting platform
Know more about Silvia Muro’s research here