Wide experience designing and fabricating biomaterials of different sizes and shapes to be used for biological and health applications like regenerative therapies. We put emphasis in the study of both the material physicochemical properties as well as understanding and tuning the cell-material interactions, biocompatibility, proteins or cell adhesion, proliferation, etc, in order to obtain a rational and functional biomaterial.
- Development of microenvironments for tissue regeneration: Cell-derived matrices for 3D in vitro cancer cell models, Decellularized tissues for development of 3D models, Multimodal platforms for tissue regeneration, Development of biomaterials that stimulate tissue regeneration (Cardiac, oral mucosa, skin, bone).
- 3D (Bio)printing of thin, homogeneous, and width-controlled free-form individual fibres that can be used with a wide variety of cell-laden hydrogels (3D-Bioprinting kit, Platform for drug discovery and development in animal-free non-clinical tests).
- Study of cell behavior as a function of the substrate stiffness or under mechanical stress. Control of biological processes though substrate properties tuning.
- Determination of membrane mechanics and fluidity, and evaluation of membrane proteins behavior under mechanical stress.
- Surface nanostructuration and functionalization for cellular functional response, like adherence, differentiation, etc.
- Topographical characterization of hard and soft surfaces (membranes/polymers), and characterization of nanomechanical properties.
- Electrochemical methods, including voltammetry and impedance spectroscopy for the characterization of materials, membranes and proteins.
- 3D bioprinting and photopolymerization (visible light and UV), patterning, molding and replica molding, microcontact printing and hot-embossing.
Formulation of biogels and bioinks: PEG-based hydrogels (acrylate chemistry), Norbornene, Pullulan, Dextran (thiol-ene chemistry), GelMA-PEGDA hydrogel co-networks, Poly acrylamide gels, PDMS, Collagen, Matrigel.