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by Keyword: Mxene nanosheets
del Río, EP, Esplugues-Lopez, A, Heyvaert, Y, Jergitsch, M, Colombi, S, Ahmadi, M, Martinez, H, Ginebra, MP, Alemán, C, Mateos-Timoneda, MA, García-Torres, J, (2026). Integrating electrical conductivity capability into 3D printed alginate-gelatin hydrogels as skin tissue constructs for temperature sensing COLLOIDS AND SURFACES B-BIOINTERFACES 257, 115206
The development of electrically conductive hydrogels has emerged as a critical advancement in soft electronics, enabling multifunctional devices for biomedical applications. This work introduces biocompatible and conductive three-dimensional (3D) printed hydrogels based on alginate-gelatin matrices, modified with gold nanoparticles (AuNPs) and MXene nanosheets (Ti3C2Tx), as electronic-engineered skin hybrid platforms for temperature sensing. The hydrogels demonstrate tunable conductivity, reaching values of 0.44 S/m for AuNPmodified and 1.04 S/m for MXene-modified samples. Structural analysis confirmed the preservation of a porous architecture, while rheological studies highlighted their mechanical integrity. Both modifications imparted temperature sensitivity, with an approximately 20 % increase in current response between 30 degrees C and 40 degrees C and sensitivities in the range from - 1.54-2.00 %degrees C- 1. These hydrogels also exhibit excellent cytocompatibility, making them ideal candidates for engineered skin scaffolds. The combination of temperature sensing and biocompatibility advances the potential use of conductive hydrogels in real-time physiological monitoring and infection detection, marking a significant contribution to the field of bioelectronics.
JTD Keywords: 3d hydrogels, Alginate-gelatin, Au nps, In-vitro, Mxene nanosheets, Nanoparticles, Scaffolds, Soft, Temperature sensor