IBEC Seminar

Engineering the cancer: from biomaterials to on-chip solutions David Caballero; Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Portugal. Cancer is a complex and multifaceted pathology, which is influenced by numerous factors, including the tumor microenvironment (TME). This environment is ... Read more

Foregrounding justice, equity and inclusion as determinants of access to precision medicine: an ethical case study of patient-derived tissue organoids. Dr. Ubaka Ogbogu, Professor and the Associate Dean Research in the Faculty of Law from the University of Alberta, Canada. Ubaka Ogbogu is a Professor and the Associate Dean Research in the Faculty of Law. ... Read more

Modeling immune-cancer interactions using a microfluidic 3D culture approach Charles Baroud, Professor at Ecole Polytechnique, France Lab head at Institut Pasteur, Paris, France Cancer immunotherapy is emerging as a transformative approach for treating cancer patients. This approach, which has shown some remarkable successes, leverages the patient's own immune cells to locate and attack the tumor ... Read more

Cellular footprints : examples of emergent memory effects in cell migration. Raphael Voituriez, Laboratoire Jean Perrin / Laboratoire de Physique Théorique de la Matière Condensée CNRS / Sorbonne Université Living cells actively migrate in their environment to perform key biological functions—from unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or cancer ... Read more

Making Science Work for Refugees and Refugees Work for Science Prof Anthony J. Ryan, OBE, University of Sheffield, UK At Zaatari refugee camp, 80,000 people face daily struggles that many of us cannot imagine are squeezed into six square kilometres. With highly qualified jobs at home, they are forcibly unemployed at the camp but embody ... Read more

Protein interactions gone awry in neurodegenerative disease Danny Hatters, Department of Biochemistry and Pharmacology | Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne,  Australia The Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine principles governing how proteins inappropriately ... Read more

How does ageing-related stiffening of brain tissue microenvironments affect the regenerative capacity of cns progenitor cells Professor of biology and bioengineering, the Hebrew University of Jerusalem, Israel. Ageing-related stiffening of neuronal microenvironments in the brain generates potent signals that attenuate the regenerative capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate. We find that ... Read more

Mechanical impact of cell delamination on tissue dynamics, in developmental and tumoral contexts Centre de Biologie Intégrative, CNRS/UMR 5088, Université Toulouse III, Toulouse, France How mechanical forces drive morphogenesis is a fundamental question in the field of biomechanics. Combining imaging, genetics, biophysical and modeling approaches, we found that apoptotic cells, far from being eliminated passively, ... Read more

Development of chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases Dr. Benjami Oller-Salvia, IQS In our group we develop chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases. In the first part of the talk, I will report our efforts toward developing strategies to construct conditionally-active ... Read more

Spatial single-cell metabolomics reveals metabolic cell states EMBL Recent discoveries put metabolism into the spotlight. Metabolism not only fuels cells but also plays key roles in health and disease. In parallel, emerging single-cell technologies opened a new world of cell types and states previously hidden beneath population averages. Yet, methods for discovering links between metabolism, ... Read more