Molecular Bionics

We are chemists, physicists, mathematicians, engineers, biologists who work alongside to design bionic units that mimic specific biological functions and/or introduce operations that do not exist in Nature. We apply a constructionist approach where we mimic biological complexity in the form of design principles to produce functional units from simple building blocks and their interactions.​ We called such an approach:  Molecular Bionics.

We are engaged in several activities involving the synthesis and characterisation of novel hierarchal materials whose properties are the result of the holistic combination of its components:

Molecular Engineering

We combine synthetic and supramolecular chemistry to tune inter/intramolecular interactions and self-assembly processes to form dynamic soft materials whose molecular, supramolecular and mesoscale structures are tuned and fit for the final application (pictured right: molecular engineering of nanoscopic structures starting from molecule passing to polymers and finally to supra molecular structures).

Physical Biology

Our materials are designed to interact with living systems and thus its biological activity is studied in high detail. We have developed and established new methodologies to study living systems and how synthetic materials interact with them combining holistically physical and life sciences (Physical Biology).

Synthetic Biology

Both know-hows are applied to study biological organisation and complexity creating synthetic surrogates that act as models, as well as to engineer novel sophisticated ways to interact with living organisms.

Somanautics

In analogy to medical bionics, where engineering and physical science converge to the design of replacement and/or enhancement of malfunctioning body parts, we take inspiration from viruses, trafficking vesicles and exosomes to apply molecular engineering to create nanoscopic carriers that can navigate the human body (Somanautics) with the final aim to improve drug delivery or create new diagnostic tools.

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• State-of-the-art facilities for cell culture including 5 class A cell cabinets: one dedicated for LPS and RNAse free cell culture and one dedicated for infected tissues
• Fluorescence Activated Cell Sorting (FACS)
• Confocal microscope to perform live cell 4D imaging
• Thermocycler
• Real-time PCR
• Automated Western Blot
• Gel Permeation Chromatography
• High-Performance Liquid Chromatography
• Ultra Performance Liquid Chromatography equipped with fluorescence, UV/Vis and Infrared and light scattering detectors
• Dynamic light scattering unit
• Nanoparticle tracking analysis
• UV and Fluorescence spectroscopy
• Automated liquid handling units
• Nanoparticle production units

• Xavier Salvatella
  IRB Barcelona
• Francesca Peiro
  Physics-University of Barcelona
• Kostas Kostarellos
  Life Science- University of Manchester/ICN2
• Giorgio Volpe
  Chemistry-UCL
• Simona Parrinello
  Cancer Institute -UCL
• Finn Werner
  Structural Biology -UCL
• Nick Lane
  Evolutionary Biology -UCL
• Darren Hargraves
  Pediatric Neuro-Oncology -UCL
• Timothy McHugh
  Clinical Microbiology =UCL
• Sebastian Brander
  Neurology -UCL
• Joan Abbott
  Physiology -King’s College London
• Molly Stevens
  Bioengineering -Imperial College London
• Stefano Angioletti-Uberti
  Materials Science -Imperial College London
• Ricardo Sapienza
  Physics -Imperial College London
• Daan Frenkel
  Chemisty-University of Cambridge
• Charlotte Williams
  Chemistry -University of Oxford
• Francesco Gervasio
  Pharmacology -University of Geneve/UCL, UK
• Francesco Stellacci
  Bionegineering -EPFL Switzerland
• Tambet Tessalu
  Cancer Biology -University of Tartu (Estonia)/ Sanford Burnham Prebys Medical Discovery Institute
• Darrel Irvine
  Bioengineering -MIT
• Xiaohe Tian
  Life Sciences University of Anhui
• Yupeng Tian
  Chemistry University of Anhui
• Lei Luo
  Pharmacy -Southwest University, China
• Kai Luo
  HuaXi hospital Sichuan University
• Darren Hargrave
  Great Ormond Street Hospital, UCLH London
• Sebastian Brander
  Queen Square National Centre for Neurology, UCLH London