Development of chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases Dr. Benjami Oller-Salvia, IQS In our group we develop chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases. In the first part of the talk, I will report our efforts toward developing strategies to construct conditionally-active ... Read more
Spatial single-cell metabolomics reveals metabolic cell states EMBL Recent discoveries put metabolism into the spotlight. Metabolism not only fuels cells but also plays key roles in health and disease. In parallel, emerging single-cell technologies opened a new world of cell types and states previously hidden beneath population averages. Yet, methods for discovering links between metabolism, ... Read more
Towards an evolutionary-driven universal therapy against (intracellular) pathogens Università degli Studi di Milano We are living a time where we believe antibiotics are the cornerstone of any infectious disease-based therapy. It is definitely out of question that antibiotics saved millions of people worldwide in the last century, and that they are still doing it very ... Read more
Building tissues to understand how tissues build themselves Zev Gartner, UCSF Cells assemble into tissues and organs through an active process termed self-organization. Harnessing tissue self-organization will ultimately advance applications as diverse as disease modeling and regenerative medicine, while revealing new strategies for fighting disease. However, progress towards these applications is limited by our incomplete ... Read more
Organ on a chip models to emulate multi systemic metabolic diseases Javier Ramon, IBEC Existing on-chip tissue models typically represent a single organ, limiting systemic drug investigations. Microscale tissue analog systems aim to improve drug and toxicity predictions across various organs. However, multi-organ devices are limited, and none have explored skeletal muscle and pancreatic islets. ... Read more
Translation and Initial Patient and Volunteer Studies with Hyperpolarized Carbon-13 MR Molecular Imaging Dan Vigneron, Department of Radiology & Biomedical Imaging, University of California San Francisco "Hyperpolarized (HP) carbon-13 MRI is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways. Over 1000 human HP carbon-13 MR studies to date have ... Read more
Awake brain surgery mapping - a way to mitigate postsurgical impairments and a door to understanding human cognition MDr Joanna Sierpowska from the Department of Cognition, Development and Educational Psychology, Institute of Neurosciences, University of Barcelona Brain mapping for language and cognition during awake brain surgeries helps neurosurgeons to mitigate postsurgical impairments. At the same ... Read more
Highlights of 20 years DNP with Merck as partner Matthias Schulze, Merck Introduction of Merck’s capabilities to supply specifically labeled tracers in different grades. Describing the milestones of DNP towards establishing that method as a powerful tool in cancer diagnostics. Outlining the challenges and the scope on projects utilizing 13 C labeled reagents. Matthias Schulze ... Read more
Reprogramming the Factory of Life to Target the Delivery of mRNA via Helical Chirality Virgil Percec, Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia Homochiral helical self-organizations are known at the macroscopic level in nature, art, architecture and science for thousands of years . However, molecular helicity was discovered in proteins ... Read more
Biomaterials for cancer study and accelerate wound healing Dr. Andy Tay , Assistant Professor, Presidential Young Professor, Department of Biomedical Engineering Magnetic hydrogels are materials containing magnetic microparticles which help transduce magnetic fields into mechanical forces. In the presence of a static magnet, the stiffness of magnetic hydrogels can be altered to investigate the reversible ... Read more