IBEC Seminar

Protein interactions gone awry in neurodegenerative disease Danny Hatters, Department of Biochemistry and Pharmacology | Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne,  Australia The Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine principles governing how proteins inappropriately ... Read more

How does ageing-related stiffening of brain tissue microenvironments affect the regenerative capacity of cns progenitor cells Professor of biology and bioengineering, the Hebrew University of Jerusalem, Israel. Ageing-related stiffening of neuronal microenvironments in the brain generates potent signals that attenuate the regenerative capacity of oligodendrocyte progenitor cells (OPCs) to proliferate and differentiate. We find that ... Read more

Mechanical impact of cell delamination on tissue dynamics, in developmental and tumoral contexts Centre de Biologie Intégrative, CNRS/UMR 5088, Université Toulouse III, Toulouse, France How mechanical forces drive morphogenesis is a fundamental question in the field of biomechanics. Combining imaging, genetics, biophysical and modeling approaches, we found that apoptotic cells, far from being eliminated passively, ... Read more

Development of chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases Dr. Benjami Oller-Salvia, IQS In our group we develop chemical and synthetic biology tools to generate biotherapeutics and to tackle brain diseases. In the first part of the talk, I will report our efforts toward developing strategies to construct conditionally-active ... Read more

Spatial single-cell metabolomics reveals metabolic cell states EMBL Recent discoveries put metabolism into the spotlight. Metabolism not only fuels cells but also plays key roles in health and disease. In parallel, emerging single-cell technologies opened a new world of cell types and states previously hidden beneath population averages. Yet, methods for discovering links between metabolism, ... Read more

Towards an evolutionary-driven universal therapy against (intracellular) pathogens Università degli Studi di Milano We are living a time where we believe antibiotics are the cornerstone of any infectious disease-based therapy. It is definitely out of question that antibiotics saved millions of people worldwide in the last century, and that they are still doing it very ... Read more

Building tissues to understand how tissues build themselves Zev Gartner, UCSF Cells assemble into tissues and organs through an active process termed self-organization. Harnessing tissue self-organization will ultimately advance applications as diverse as disease modeling and regenerative medicine, while revealing new strategies for fighting disease. However, progress towards these applications is limited by our incomplete ... Read more

Organ on a chip models to emulate multi systemic metabolic diseases Javier Ramon, IBEC Existing on-chip tissue models typically represent a single organ, limiting systemic drug investigations. Microscale tissue analog systems aim to improve drug and toxicity predictions across various organs. However, multi-organ devices are limited, and none have explored skeletal muscle and pancreatic islets. ... Read more

Translation and Initial Patient and Volunteer Studies with Hyperpolarized Carbon-13 MR Molecular Imaging Dan Vigneron, Department of Radiology & Biomedical Imaging, University of California San Francisco "Hyperpolarized (HP) carbon-13 MRI is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways. Over 1000 human HP carbon-13 MR studies to date have ... Read more

Awake brain surgery mapping - a way to mitigate postsurgical impairments and a door to understanding human cognition MDr Joanna Sierpowska from the Department of Cognition, Development and Educational Psychology, Institute of Neurosciences, University of Barcelona Brain mapping for language and cognition during awake brain surgeries helps neurosurgeons to mitigate postsurgical impairments. At the same ... Read more