IBEC Seminar

Targeted protein degradation: genetic determinants and drug discovery opportunities Cristina Mayor-Ruiz, IRBarcelona Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are "molecular glue degraders": compounds that can degrade otherwise unligandable proteins by orchestrating direct interactions between target and E3. However, ... Read more

The effect of gene loss on adaptation | 3D cell shape analysis in embryos Rob Jelier, CMPG - Predictive Genetics and Multicellular Systems University of Leuven In this talk I will summarize two research projects. First, I will report on a large-scale experimental evolution study into the effect of gene deletion on adaptation. We found ... Read more

Therapeutic effects of HDAC3 inhibition on spinal injuries and autoimmune demyelinating diseases Arnau Hervera, Molecular and Cellular Neurobiotechnology The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord injury ... Read more

Updates on a new lab at IBEC: hyperpolarised magnetic resonance for real-time, in situ monitoring of cell metabolism Irene Marco, Molecular Imaging for Precision Medicine group at IBEC There is a clinical need for non-invasive and reliable markers to diagnose, stage and evaluate treatment response in many diseases such as cancer or non-alcoholic fatty liver ... Read more

Smart and multifunctional artificial materials for bioengineering Carlos Alemán, Universitat Politècnica de Catalunta (UPC) The research of the " Innovation, Modeling & Engineering in Materials" group in the field of multifunctional materials. Three, different examples of multifunctional systems will be presented: 1) Magnetic electroconductive and self-healing PEDOT:alginate hydrogels for sensing, drug-delivery and energy storage; 2) ... Read more

Biomechanics of the progression of colorectal carcinomas Giulia Fornabaio, Synthetic morphogenesis group According to the World Health Organization, cancer is one of the main causes of death worldwide, with colorectal carcinoma (CRC) being the second-leading cause of tumour related-death. The high rate of mortality of CRCs is principally attributed to the metastasis of neoplastic cells ... Read more

Regenerative Neuroimmunology - new generation molecular approaches to restore maladaptive inflammatory responses in the persistently inflamed CNS Stefano Pulchino, University of Cambridge There are currently no approved therapies to slow down the accumulation of neurological disability that occurs independently of relapses in multiple sclerosis (MS). International agencies are engaging to expedite the development of novel ... Read more

Regenerative Neuroimmunology - new generation molecular approaches to restore maladaptive inflammatory responses in the persistently inflamed CNS Stefano Pulchino, University of Cambridge There are currently no approved therapies to slow down the accumulation of neurological disability that occurs independently of relapses in multiple sclerosis (MS). International agencies are engaging to expedite the development of novel ... Read more

Regenerative Neuroimmunology - new generation molecular approaches to restore maladaptive inflammatory responses in the persistently inflamed CNS Stefano Pulchino, University of Cambridge There are currently no approved therapies to slow down the accumulation of neurological disability that occurs independently of relapses in multiple sclerosis (MS). International agencies are engaging to expedite the development of novel ... Read more

NanoWizard® V BioScience - The latest Generation AFM for Automated Structural and Mechanical Analysis & NanoRacer® – High-Speed AFM for dynamical processes André Körnig, JPK BioAFM, Bruker Nano GmbH The ability of atomic force microscopy (AFM) to obtain three-dimensional topography images of biological molecules and complexes with nanometer resolution and under near-physiological conditions remains unmatched ... Read more