IBEC Seminar

Single molecule insights into cellular mechanotransduction Sergi Garcia-Manyes, Single Molecule Mechanobiology laboratory, The Francis Crick Institute and King’s College London   Cellular mechanostransduction relies on the conversion of mechanical cues into chemical signals, which propagate from the focal adhesion hub through the cytoskeleton to ultimately reach the nucleus through the Nuclear Pore Complex (NPC), and ... Read more

Engineering the Nanoscale Membrane Topography in Cells Wenting Zhao, School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore and Institute for Digital Molecular Analytics and Science (IDMxS), Singapore  Abstract. Cell membranes serve as a central platform to host a variety of proteins essential for cellular activities such as cell signaling, morphogenesis, and membrane ... Read more

Enhanced regeneration through in vivo cell reprogramming: lessons from the first decade of research and a success story in the mouse heart Irene de Lázaro, PhD1,2,3 1 Department of Biomedical Engineering, NYU Tandon School of Engineering, New York University 2 Cardiovascular Research Center, NYU School of Medicine and NYU Langone Health 3 Harvard John A ... Read more

Nuclear mechanobiology – from striated muscle disease to ultrarapid cellular mechanosensing Jan Lammerding, PhD, Weill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA Abstract. The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is investigating ... Read more

Developability assessment of biologics and formulation of novel molecules Shahid Uddin, PhD, MBA, Senior Director of Drug Product, Formulation & Stability within the CMC department at Immunocore, UK It’s vital to ensure appropriate assessment of molecules at the early research phase is carried out to risk mitigate movement into the development phase. This ensures the best risk ... Read more

Nanomedicine to Tackle Unmet Medical Needs in CNS Disorders Sabina Quader, Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821 Japan The brain is undoubtedly the body's most essential and intricate organ, and brain disorders are closely tied to this intricacy. Categorized as "CNS diseases," a wide range of brain-related conditions - ... Read more

Semi-synthetic nucleosomes to stabilize and image enzyme-chromatin interactions Carlos Moreno Yruela, Researcher in Chemical Biology, EPFL, Switzerland Chromatin structure regulates gene expression and is tightly controlled by histone post-translational modifications. SIRT7 is a histone lysine deacylase found to maintain oncogenic gene expression profiles supporting tumor growth and metastasis. Interestingly, the activity of SIRT7 is fully ... Read more

Harnessing the power of stem cell therapy in an off-the-shelf nano-delivery platform for treating brain disorders Prof Marcelle Machluf, Faculty of Biotechnology and Food Engineering, Technion, Haifa, Israel Mesenchymal stem cells (MSCs) have gained the most attention in cell therapy, owing to their ability to traverse physiological barriers, and target different sites of inflammation including ... Read more

Advances in understanding and manipulating influenza A virus liquid inclusions Maria João Amorim, PhD, Group Leader, Cell Biology of Viral Infection Lab, Católica Biomedical Research Centre, Universidade Católica Portuguesa, and Instituto Gulbenkian de Ciência, Portugal Many viruses form biomolecular condensates de novo as part of their replication programmes. Influenza A virus is an important human pathogen ... Read more

3D architecture and mechanism of touch detection in the Pacinian corpuscle Slav Bagriantsev, Associate Professor of Cellular & Molecular Physiology, Yale School of Medicine, USA Pacinian corpuscles are specialized mechanoreceptor end-organs that detect transient touch and high-frequency vibration in the skin and viscera of many vertebrates. Corpuscles have a complex cellular organization, which includes a ... Read more