Targeted protein degradation: genetic determinants and drug discovery opportunities Cristina Mayor-Ruiz, IRBarcelona Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are "molecular glue degraders": compounds that can degrade otherwise unligandable proteins by orchestrating direct interactions between target and E3. However, ... Read more

The effect of gene loss on adaptation | 3D cell shape analysis in embryos Rob Jelier, CMPG - Predictive Genetics and Multicellular Systems University of Leuven In this talk I will summarize two research projects. First, I will report on a large-scale experimental evolution study into the effect of gene deletion on adaptation. We found ... Read more