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Workshop “Bioaction: The new tissue engineering approaches in bone infections»
martes, octubre 10, 2023 @ 2:30 pm–4:30 pm
Workshop held in the framework of the EIC Pathfinder project BIOACTION “Bacteria biofilm as bio-factory for tissue regeneration” (Project Number 101098972).
BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone.
BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project is strongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine.
As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine.
In this workshop, participants from all the institutions involved in the project will explain their research and activities.
Chairs: Elisabeth Engel, Luigi Ambrosio
14:30 – Claudia Siverini and Marco Chittò (AO Foundation), “Bone infections and treatments”
14:45 – Dorien Van Hede (Université de Liege), “Dental infections and treatments”
15:00 – Diego Cotella (Università degli Studi del Piemonte Orientale), «Phages to control biofilms»
15:15 – Dr. Cecilia Bombelli (Consiglio Nazionale delle Ricerche – Instituto per i Sistemi biologici), «Liposomes in gene therapy»
15:30 – Ramūnas Valiokas (Ferentis), “Crosslinked peptide hydrogels for tissue engineering and modeling”
15:45 – Giovanna Gomez d’Ayala (Consiglio Nazionale delle Ricerche – Instituto per i Polimeri, Compositi e Biomateriali), “Hydrogels for tissue regeneration”
16:00 – Oscar Castaño (IBEC), “Advanced characterization methodology”
16:15 – Roberta Marzella (Consiglio Nazionale delle Ricerche – IPCB) and Michela Candotti (IN Society) – “Tips on Management and Dissemination of European Projects”
16:30 Discussion and conclusions
