Researchers from IBEC, the UCL (UK), UPC (Spain) and the TU/e (Netherlands) show that activation of the RAS oncogene (a mutation occurring in approximately 30% of human cancers), induces tumour features in an epithelium via coordinated physical changes of all cells forming the affected tissue. Published in the scientific journal Science Advances, the new work suggests that future cancer treatments should target both the biological processes underlying the disease and the evolving mechanical structure of the affected tissue.