ABOUT
OUR FOCUS
Development and application of innovative techniques for biomarker in human diseases.
We believe that utilizing molecular imaging tools we can uncover abnormalities in cell metabolism and assess treatment efficacy.
OUR APPROACH
Combining principles from bioengineering, chemistry, and physics, we tackle biological challenges through innovative solutions. Application of Magnetic Resonance (MR) molecular imaging methods to investigate biochemical pathways and in vitro, in vivo and in innovative in bioengineered chip systems.
OUR METHODS
Hyperpolarised NMR (HP-NMR)
At the forefront of molecular imaging, our team specializes in hyperpolarized MR techniques, which amplify NMR signals over 10,000 times. This advancement allows real-time, non-invasive observation of molecular processes within a broad spectrum of biological systems, offering unprecedented insights into dynamic biological phenomena in real time. In our group we work with two HP methods: dissolution Dynamic nuclear polarization (dDDNP) and Parahydrogen Induced Polarization (PHIP).
Magnetic Resonance (MR) Imaging
Building upon the established clinical utility of MR imaging (MRI) for non-destructive tissue analysis, our work extends to MR spectroscopic imaging, which offers chemical specificity. This enables direct correlation between chemical compounds and biological events across various biological samples, including biofluids, cells, tissues, animal models, and clinical patients.
Microfluidic platforms
Microfluidic platforms, especially lab-on-a-chip devices, are revolutionizing the study of metabolism in disease by offering a compact and efficient means to analyze biological samples. These chips integrate intricate networks of microchannels and chambers, allowing for precise control and manipulation of small fluid volumes. A significant advantage of these platforms is their ability to accommodate multiple samples simultaneously for a single measurement, such as Magnetic Resonance Imaging (MRI). This unique design not only enhances throughput and reduces sample consumption but also enables high-resolution and multiplexed metabolic analysis. Consequently, microfluidic chips are becoming indispensable tools in biomedical research, providing valuable insights into disease mechanisms and facilitating the identification of metabolic biomarkers.
Metabolomics
Metabolomics is the comprehensive study of metabolites, the small molecules involved in metabolic processes within a biological system. Analysis of metabolites using NMR spectroscopy reveals insights into the biochemical activities occurring in cells, tissues, or organisms. This field is particularly useful for biomarker identification associated with particular diseases. Identifying these biomarkers can improve disease diagnosis, prognosis, and the development of personalized treatment strategies.
Computer Modelling of biological systems
By using the law of mass action, it is possible to model different cellular processes in a deterministic manner, and hence, describe these systems at a population level. These models can describe a wide range of processes, from gene expression and regulation to enzyme kinetics and particles movements thanks to membrane transporters.
STAFF
All group members:
ibecbarcelona.euPROJECTS
| INTERNATIONAL PROJETCS | FINANCER | PI |
|---|---|---|
| BLOC · Benchtop NMR for Lab-on-Chip (2020 – 2022) | European Commission, FET OPEN | Irene Marco |
| NATIONAL PROJECTS | FINANCER | PI |
|---|---|---|
| Analisis metabolico en tiempo real de modelos de cultivo de celulas 3d de la enfermedad del higado graso no alcoholico: organos en un chip y resonancia magnetica nuclear (2020 – 2021) | MINECO, Acciones Dinamización Europa Investigación/EIN2020-112209 | Irene Marco |
| Junior Leader Programe (2018 – 2022) | Obra Social La Caixa, Junior Leader Program | Irene Marco |
PUBLICATIONS
For a list of publications prior to joining IBEC, visit the Google Scholar.
NEWS
¿Cómo elegir el mejor fármaco para cada paciente con cáncer? Irene Marco en BigVan de La Vanguardia
Irene Marco explica en la sección BigVan de La Vanguardia cómo gracias a la microfluídica y a la investigación basada en el uso de dispositivos «organ-on-a-chip» se puede dar un gran salto hacia la medicina personalizada.
Cinco investigadores del IBEC galardonados en la ceremonia de las becas de «la Caixa»
Cinco investigadores del IBEC recibieron ayer becas de «la Caixa» a las convocatorias de investigación e innovación. Anna Labernadie e Irene Marco, ambas estudiantes postdoctorales en los grupos del IBEC «Integrative Cell and Tissue Dynamics» y «Biosensors for Bioengineering», respectivamente, han obtenido las becas en la primera convocatoria del programa Junior Leader de “la Caixa”, que ayuda investigadores e investigadoras destacados, de cualquier nacionalidad, que quieran continuar su carrera de investigación en territorio español o portugués. Anna ha sido una de las 10 estudiantes postdoctorales en conseguir una beca en la modalidad “Retaining” para candidatos que ya residen en España, e Irene ha sido galardonada con una de las 20 becas en la modalidad “Incoming” para candidatos residentes en el extranjero.