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IBEC Seminar: Agathe Chaigne
Friday, March 8 @ 10:00 am–11:00 am
Molecular and mechanical regulation of abscission in stem cells
Agathe Chaigne, PhD., Group leader. Cell Biology, Neurobiology and Biophysics department, Utrecht University, The Netherlands
Abscission is the last step of cell division leading to the complete separation of the two sister cells and consists in the cutting of a cytoplasmic bridge. Abscission is mediated by the membrane remodelling machinery ESCRT which also triggers the severing of a thick bundle of microtubules that needs to be cleared prior to abscission. Here, we use mouse embryonic stem cells, which transition from slow to fast abscission during exit from naïve pluripotency to investigate the molecular mechanism for abscission dynamics. We identify a feedback loop between the activity of Aurora B, mechanics, and microtubule stability as a main regulator of abscission speed.
