The generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic.
Successful replacement, or augmentation, of the function of damaged cells by patient derived differentiated stem cells would provide a novel cell-based therapy for diseases. Since iPSCs resemble human embryonic stem cells (hESCs) in their ability to generate cells of three germ layers, patient-specific iPSCs offer definitive solutions for the ethical and histo-incompatibility issues related to hESCs. Indeed human iPSC (hiPSC)-based autologous transplantation is heralded as the future of regenerative medicine.
One of our aims is to generate and correct disease-specific hiPSCs for disease modelling and drug screening. The combination of gene-editing based methodologies together with the development of novel protocols for cell differentiation into relevant tissues/organs, provides a unique scenario for modelling disease progression, and the identification of molecular and cellular mechanisms leading to organ regeneration (Figure 1). In this regard we are particularly interested in generation of transgene-free and disease free patient derived hiPSCs for disease modelling and the discovery of novel therapeutic targets.
We believe that the recovery of tissue function should not be restricted to the development of cell replacement therapies. In this regard, in our laboratory we take advantage of organisms that possess the ability to regenerate such as zebrafish, in order to understand which molecular and cellular pathways lead to organ regeneration. Surprisingly, studies in neonatal mice have demonstrated that soon after birth this organism posses the capability to regenerate its heart. Taking advantage of such preliminary observations we are translating such analysis in order to understand if the mammalian neonatal kidney still posses the capability to regenerate, and more importantly, if we are able to dissect the epigenetic and cellular mechanisms leading to those responses.
Lastly, and in an effort to fully develop in vitro and ex vivo platforms for organ regeneration, in our lab we are focused in the development of reporter cell lines for different transcription factors essential for tissue-specific commitment and differentiation (i.e: renal and cardiac lineages). The possibility to combine pluripotent stem cell lines together with decellularized matrices, functionalized biomaterials and ex vivo organoids offers and unprecedented opportunity for the immediate generation of patient-specific in vitro and ex vivo platforms for disease modelling and organ regeneration (Figure 2).
Núria Montserrat Pulido | Group Leader / ICREA Research Professor
Elena Garreta Bahima | Senior Researcher
Andrés Marco Giménez | Postdoctoral Researcher
Carolina Tarantino | Senior Technician
Aurora García Robles | Project Manager
Gaia Amato | PhD Student
Maria Gallo | PhD Student
Zarina Nauryzgaliyeva | PhD Student
Aleix Martínez Oliver | Laboratory Technician
Daniel Moya Rull | Laboratory Technician
Ricard Artiga | Masters Student
Phillipp Boder | Visiting Researcher
Wajima Safi | Visiting Researcher
|BRAV3. Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts (2020-2024)||European Commission||Núria Montserrat|
|MAD-CoV 2 · Modern approaches for developing antivirals against SARS-CoV 2 (2020-2024)||European Commission||Núria Montserrat|
|R2U-Tox-Assay · Ready-to-use Toxicity Screening Assay based on iPS-Technologies (2020-2022)||EIT Health||Núria Montserrat|
|Bioengeniería para mejorar la salud mediante de organoides y bioimpresión 3D (2021-2023)||MINECO – Plataformas ISCIII de apoyo a la I+D+I en Biomedicina y Ciencias de la Salud||Núria Montserrat|
|ACE2-ORG · Development of a human cellular plaform unveilling Angiotensin-converting enzyme 2 (ACE2) – sars-CoV-2 interactions (2020-2021)||ISCIII||Núria Montserrat|
|Red TERCEL · Red de Terapia Celular (2017-2021)||MINECO, ISCIII||(Collaborator)|
|CHONDREG · Identification of the epigenetic mechanisms preventing chondrocyte de-differentiation: generation of novel therapeutic strategies for the treatment of cartilage chronic osteochondral lesions||CIBER||Nuria Montserrat|
|Infarto de miocardio en jóvenes. Factores epigeneticos y nuevos marcadores de riesgo cardiovascular. Efecto de la modulación de la expresión de microRNAs y long-non coding RNAs||ISCIII||(Collaborator)|
|REPIRE · Regenerating photoreceptors in human retinal organoids to establish a treatment for Retinitis Pigmentosa (2018-2021)||Fundación Bancaria “La Caixa”||Núria Montserrat|
|Programa Faster Future 2020: COVID-19 (2021)||Fundraising||Núria Montserrat|
|Identification of Kidney Cancer progression targets and biomarkers through CRISPR-engineered organoids and xenograft mouse models (2019-2020)||Fundació La Marató de TV3||Núria Montserrat|
|Generation of Isogenic Models of Clear Cell Renal Cell Carcinoma (ccRCC) using CRISPR-engineered Kidney Organoids, for the identification of diagnostic biomarkers (2017-2020)||Fundación AECC||Núria Montserrat|
|EPIORG · Cómo modelar la Nefropatía Diabética: restableciendo el epigenoma en organoides renales diabéticos inducidos (2018-2020)||MINECO, Retos investigación: Proyectos I+D||Núria Montserrat|
|MECHANORG · Como integrar señales mecánicas y metabólicas en organoides renales para el modelado de patologías humanas (2019-2020)||MINECO, Acciones Dinamización Europa Investigación||Núria Montserrat|
|Modelling Diabetic Nephropathy targeting DNA methylation: engineering the epigenome in kidney (2019-2020)||EFSD European Foundation for the Study of Diabetes||Núria Montserrat|
|REGMAMKID · How to regenerate the mammalian kidney (2015-2020)||European Commission, ERC-StG||Núria Montserrat|
|REPROMICRO · Reprogramacion y regeneracion tisular a partir de microvesiculas derivadas de celulas madre de pluripotencia inducida (2017-2019)||Ministerio de Economía y Competitividad, Explora Ciencia||Nuria Montserrat|
|Desarrollo de nuevas estrategias para el tratamiento de la enfermedad renal (2015-2017)||MINECO||Nuria Montserrat|
|TRATENFREN · Desarrollo de nuevas estrategias para el tratamiento de la enfermedad renal (2015-2017)||MINECO, Retos investigación: Proyectos I+D||Nuria Montserrat|
|Regenerative medicine for Fanconi anemia: generation of disease-free patient-specific iPS (2013-2016)||Fundació La Marató de TV3||Nuria Montserrat|
Aydin, Onur, Passaro, Austin P., Raman, Ritu, Spellicy, Samantha E., Weinberg, Robert P., Kamm, Roger D., Sample, Matthew, Truskey, George A., Zartman, Jeremiah, Dar, Roy D., Palacios, Sebastian, Wang, Jason, Tordoff, Jesse, Montserrat, Nuria, Bashir, Rashid, Saif, MTaher A., Weiss, Ron, (2022). Principles for the design of multicellular engineered living systems Apl Bioengineering 6, 010903
Garreta E, Nauryzgaliyeva Z, Marco A, Safi W, Montserrat N, (2022). Dissecting nephron morphogenesis using kidney organoids from human pluripotent stem cells Current Opinion In Genetics & Development 72, 22-29
Garreta, E, Nauryzgaliyeva, Z, Montserrat, N, (2021). Human induced pluripotent stem cell-derived kidney organoids toward clinical implementations Curr Opin Biomed Eng 20,
Molins, B, Garreta, E, del Pozo, CH, Adan, A, Montserrat, N, (2021). Modelling retinal disease with a blood-retinal-barrier in vitro system combining human pluripotent stem cells and decellularized retinal tissue Investigative Ophthalmology & Visual Science 62,
Soblechero-Martín P, Albiasu-Arteta E, Anton-Martinez A, de la Puente-Ovejero L, Garcia-Jimenez I, González-Iglesias G, Larrañaga-Aiestaran I, López-Martínez A, Poyatos-García J, Ruiz-Del-Yerro E, Gonzalez F, Arechavala-Gomeza V, (2021). Duchenne muscular dystrophy cell culture models created by CRISPR/Cas9 gene editing and their application in drug screening Scientific Reports 11, 18188
Berishvili E, Casiraghi F, Amarelli C, Scholz H, Piemonti L, Berney T, Montserrat N, (2021). Mini-organs forum: how to advance organoid technology to organ transplant community Transplant International 34, 1588-1593
Pilat N, Lefsihane K, Brouard S, Kotsch K, Falk C, Steiner R, Thaunat O, Fusil F, Montserrat N, Amarelli C, Casiraghi F, (2021). T- and B-cell therapy in solid organ transplantation: current evidence and future expectations Transplant International 34, 1594-1606
Calistri A, Luganini A, Mognetti B, Elder E, Sibille G, Conciatori V, Del Vecchio C, Sainas S, Boschi D, Montserrat N, Mirazimi A, Lolli ML, Gribaudo G, Parolin C, (2021). The new generation hdhodh inhibitor meds433 hinders the in vitro replication of sars-cov-2 and other human coronaviruses Microorganisms 9, 1731
Lovell-Badge R, Anthony E, Barker RA, Bubela T, Brivanlou AH, Carpenter M, Charo RA, Clark A, Clayton E, Cong Y, Daley GQ, Fu J, Fujita M, Greenfield A, Goldman SA, Hill L, Hyun I, Isasi R, Kahn J, Kato K, Kim JS, Kimmelman J, Knoblich JA, Mathews D, Montserrat N, Mosher J, Munsie M, Nakauchi H, Naldini L, Naughton G, Niakan K, Ogbogu U, Pedersen R, Rivron N, Rooke H, Rossant J, Round J, Saitou M, Sipp D, Steffann J, Sugarman J, Surani A, Takahashi J, Tang F, Turner L, Zettler PJ, Zhai X, (2021). ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update Stem Cell Reports 16, 1398-1408
Hyun I, Clayton EW, Cong Y, Fujita M, Goldman SA, Hill LR, Monserrat N, Nakauchi H, Pedersen RA, Rooke HM, Takahashi J, Knoblich JA, (2021). ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts Stem Cell Reports 16, 1409-1415
Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M, Trepat X, (2021). Addendum: Active superelasticity in three-dimensional epithelia of controlled shape Nature 592, E30
Dhillon P, Park J, Hurtado del Pozo C, Li L, Doke T, Huang S, Zhao J, Kang HM, Shrestra R, Balzer MS, Chatterjee S, Prado P, Han SY, Liu H, Sheng X, Dierickx P, Batmanov K, Romero JP, Prósper F, Li M, Pei L, Kim J, Montserrat N, Susztak K, (2021). The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation Cell Metabolism 33, 379-394.e8
Selfa IL, Gallo M, Montserrat N, Garreta E, (2021). Directed Differentiation of Human Pluripotent Stem Cells for the Generation of High-Order Kidney Organoids Methods In Molecular Biology 2258, 171-192
Monteil V, Dyczynski M, Lauschke VM, Kwon H, Wirnsberger G, Youhanna S, Zhang H, Slutsky AS, Hurtado del Pozo C, Horn M, Montserrat N, Penninger JM, Mirazimi A, (2021). Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection Embo Molecular Medicine 13, e13426
Garreta, Elena, Kamm, Roger D., Chuva de Sousa Lopes, Susana M., Lancaster, Madeline A., Weiss, Ron, Trepat, Xavier, Hyun, Insoo, Montserrat, Nuria, (2021). Rethinking organoid technology through bioengineering Nature Materials 20, 145-155
Kyndiah, A., Leonardi, F., Tarantino, C., Cramer, T., Millan-Solsona, R., Garreta, E., Montserrat, N., Mas-Torrent, M., Gomila, G., (2020). Bioelectronic recordings of cardiomyocytes with accumulation mode electrolyte gated organic field effect transistors Biosensors and Bioelectronics 150, 111844
Hoogduijn, M.J., Montserrat, N., van der Laan, L.J.W., Dazzi, F., Perico, N., Kastrup, J., Gilbo, N., Ploeg, R.J., Roobrouck, V., Casiraghi, F., Johnson, C.L., Franquesa, M., Dahlke, M.H., Massey, E., Hosgood, S., Reinders, M.E.J., (2020). The emergence of regenerative medicine in organ transplantation: 1st European Cell Therapy and Organ Regeneration Section meeting Transplant International 33, (8), 833-840
Lynch, Cian J., Bernad, Raquel, Martínez-Val, Ana, Shahbazi, Marta N., Nóbrega-Pereira, Sandrina, Calvo, Isabel, Blanco-Aparicio, Carmen, Tarantino, Carolina, Garreta, Elena, Richart-Ginés, Laia, Alcazar, Noelia, Graña-Castro, Osvaldo, Gómez-Lopez, Gonzalo, Aksoy, Irene, Muñoz-Martín, Maribel, Martinez, Sonia, Ortega, Sagrario, Prieto, Susana, Simboeck, Elisabeth, Camasses, Alain, Stephan-Otto Attolini, Camille, Fernandez, Agustin F., Sierra, Marta I., Fraga, Mario F., Pastor, Joaquin, Fisher, Daniel, Montserrat, Nuria, Savatier, Pierre, Muñoz, Javier, Zernicka-Goetz, Magdalena, Serrano, Manuel, (2020). Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases Nature Cell Biology 22, (10), 1223-1238
Zoufaly, Alexander, Poglitsch, Marko, Aberle, Judith H., Hoepler, Wolfgang, Seitz, Tamara, Traugott, Marianna, Grieb, Alexander, Pawelka, Erich, Laferl, Hermann, Wenisch, Christoph, Neuhold, Stephanie, Haider, Doris, Stiasny, Karin, Bergthaler, Andreas, Puchhammer-Stoeckl, Elisabeth, Mirazimi, Ali, Montserrat, Nuria, Zhang, Haibo, Slutsky, Arthur S., Penninger, Josef M., (2020). Human recombinant soluble ACE2 in severe COVID-19 The Lancet Respiratory Medicine 8, (11), 1154-1158
Monteil, Vanessa, Dyczynski, Matheus, Lauschke, Volker M., Kwon, Hyesoo, Wirnsberger, Gerald, Youhanna, Sonia, Zhang, Haibo, Slutsky, Arthur S., Hurtado del Pozo, Carmen, Horn, Moritz, Montserrat, Nuria, Penninger, Josef M., Mirazimi, Ali, (2020). Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection EMBO Molecular Medicine , e13426
Monteil, Vanessa, Kwon, Hyesoo, Prado, Patricia, Hagelkrüys, Astrid, Wimmer, Reiner A., Stahl, Martin, Leopoldi, Alexandra, Garreta, Elena, Hurtado Del Pozo, Carmen, Prosper, Felipe, Romero, Juan Pablo, Wirnsberger, Gerald, Zhang, Haibo, Slutsky, Arthur S., Conder, Ryan, Montserrat, Nuria, Mirazimi, Ali, Penninger, Josef M., (2020). Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2 Cell 181, (4), 905-913.e7
Cilloni, Daniela, Petiti, Jessica, Campia, Valentina, Podestà , Marina, Squillario, Margherita, Montserrat, Nuria, Bertaina, Alice, Sabatini, Federica, Carturan, Sonia, Berger, Massimo, Saglio, Francesco, Bandini, Giuseppe, Bonifazi, Francesca, Fagioli, Franca, Moretta, Lorenzo, Saglio, Giuseppe, Verri, Alessandro, Barla, Annalisa, Locatelli, Franco, Frassoni, Francesco, (2020). Transplantation induces profound changes in the transcriptional asset of hematopoietic stem cells: Identification of specific signatures using machine learning techniques Journal of Clinical Medicine 9, (6), 1670
Garreta, Elena, Prado, Patricia, Tarantino, Carolina, Oria, Roger, Fanlo, Lucia, Martí, Elisa, Zalvidea, Dobryna, Trepat, Xavier, Roca-Cusachs, Pere, Gavaldà -Navarro, Aleix, Cozzuto, Luca, Campistol, Josep M., Izpisúa Belmonte, Juan Carlos, Hurtado del Pozo, Carmen, Montserrat, Nuria, (2019). Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells Nature Materials 18, 397-405
Sample, Matthew, Boulicault, Marion, Allen, Caley, Bashir, Rashid, Hyun, Insoo, Levis, Megan, Lowenthal, Caroline, Mertz, David, Montserrat, Nuria, Palmer, Megan J., Saha, Krishanu, Zartman, Jeremiah, (2019). Multi-cellular engineered living systems: building a community around responsible research on emergence Biofabrication 11, (4), 043001
Garreta, Elena, Montserrat, Nuria, Belmonte, Juan Carlos Izpisua, (2018). Kidney organoids for disease modeling Oncotarget 9, (16), 12552-12553
Garreta, Elena, Sanchez, Sonia, Lajara, Jeronimo, Montserrat, Nuria, Belmonte, Juan Carlos Izpisua, (2018). Roadblocks in the path of iPSC to the vlinic Current Transplantation Reports 5, (1), 14-18
Latorre, Ernest, Kale, Sohan, Casares, Laura, Gómez-González, Manuel, Uroz, Marina, Valon, Léo, Nair, Roshna V., Garreta, Elena, Montserrat, Nuria, del Campo, Aránzazu, Ladoux, Benoit, Arroyo, Marino, Trepat, Xavier, (2018). Active superelasticity in three-dimensional epithelia of controlled shape Nature 563, (7730), 203-208
Hernandez-Benitez, R., Llanos Martinez-Martinez, M., Lajara, J., Magistretti, P., Montserrat, N., Izpisua Belmonte, Juan Carlos, (2018). At the heart of genome editing and cardiovascular diseases Circulation Research 123, (2), 221-223
Niederberger, Craig, Pellicer, Antonio, Cohen, Jacques, Gardner, David K., Palermo, Gianpiero D., O'Neill, Claire L., Chow, Stephen, Rosenwaks, Zev, Cobo, Ana, Swain, Jason E., Schoolcraft, William B., Frydman, René, Bishop, Lauren A., Aharon, Davora, Gordon, Catherine, New, Erika, Decherney, Alan, Tan, Seang Lin, Paulson, Richard J., Goldfarb, James M., Brännström, Mats, Donnez, Jacques, Silber, Sherman, Dolmans, Marie-Madeleine, Simpson, Joe Leigh, Handyside, Alan H., Munné, Santiago, Eguizabal, Cristina, Montserrat, Nuria, Izpisua Belmonte, Juan Carlos, Trounson, Alan, Simon, Carlos, Tulandi, Togas, Giudice, Linda C., Norman, Robert J., Hsueh, Aaron J., Sun, Yingpu, Laufer, Neri, Kochman, Ronit, Eldar-Geva, Talia, Lunenfeld, Bruno, Ezcurra, Diego, D'Hooghe, Thomas, Fauser, Bart C. J. M., Tarlatzis, Basil C., Meldrum, David R., Casper, Robert F., Fatemi, Human M., Devroey, Paul, Galliano, Daniela, Wikland, Matts, Sigman, Mark, Schoor, Richard A., Goldstein, Marc, Lipshultz, Larry I., Schlegel, Peter N., Hussein, Alayman, Oates, Robert D., Brannigan, Robert E., Ross, Heather E., Pennings, Guido, Klock, Susan C., Brown, Simon, Van Steirteghem, André, Rebar, Robert W., LaBarbera, Andrew R., (2018). Forty years of IVF Fertility and Sterility 110, (2), 185-324
Hurtado del Pozo, Carmen, Garreta, Elena, Izpisúa Belmonte, Juan Carlos, Montserrat, Nuria, (2018). Modeling epigenetic modifications in renal development and disease with organoids and genome editing Disease Models & Mechanisms 11, (11), 035048
Garreta, E., González, F., Montserrat, N., (2018). Studying kidney disease using tissue and genome engineering in human pluripotent stem cells Nephron 138, 48-59
Garreta, Elena, Oria, Roger, Tarantino, Carolina, Pla-Roca, Mateu, Prado, Patricia, Fernández-Avilés, Francisco, Campistol, Josep Maria, Samitier, Josep, Montserrat, Nuria, (2017). Tissue engineering by decellularization and 3D bioprinting Materials Today , 20, (4), 166-178
Climent, A. M., Hernandez-Romero, I., Guillem, M. S., Montserrat, N., Fernandez, M. E., Atienza, F., Fernandez-Aviles, F., (2017). High resolution microscopic optical mapping of anatomical and functional reentries in human cardiac cell cultures IEEE Conference Publications Computing in Cardiology Conference (CinC), 2016 , IEEE (Vancouver, Canada) 43, 233-236
Garreta, Elena, Marco, Andrés, Eguizábal, Cristina, Tarantino, Carolina, Samitier, Mireia, Badiola, Maider, Gutiérrez, Joaquín, Samitier, Josep, Montserrat, Nuria, (2017). Pluripotent stem cells and skeletal muscle differentiation: Challenges and immediate applications The Plasticity of Skeletal Muscle: From Molecular Mechanism to Clinical Applications (ed. Sakuma, Kunihiro), Springer Singapore (Singapore, Singapore) 2018, 1-35
Xia, Yun, Montserrat, Nuria, Campistol, Josep M., Izpisua Belmonte, Juan Carlos, Remuzzi, Giuseppe, Williams, David F., (2017). Lineage reprogramming toward kidney regeneration Kidney Transplantation, Bioengineering and Regeneration (ed. Orlando, G., Remuzzi, Giuseppe, Williams, David F.), Academic Press (London, UK) , 1167-1175
Garreta, Elena, Marco, Andres, Izpisua Belmonte, Juan Carlos, Montserrat, Nuria, (2016). Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease Stem Cell Investigation , 4, (11), 1-4
Garreta, E., de Oñate, L., Fernández-Santos, M. E., Oria, R., Tarantino, C., Climent, A. M., Marco, A., Samitier, M., Martínez, Elena, Valls-Margarit, M., Matesanz, R., Taylor, D. A., Fernández-Avilés, F., Izpisua Belmonte, J. C., Montserrat, N., (2016). Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts Biomaterials 98, 64-78
Eguizabal, C., Herrera, L., De Oñate, L., Montserrat, N., Hajkova, P., Izpisua Belmonte, J. C., (2016). Characterization of the epigenetic changes during human gonadal primordial germ cells reprogramming Stem Cells , 34, (9), 2418-2428
Castaño, J., Herrero, A. B., Bursen, A., González, F., Marschalek, R., Gutiérrez, N. C., Menendez, P., (2016). Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair Oncotarget 7, (21), 30440-30452
Montserrat, N., Garreta, E., Izpisua Belmonte, J. C., (2016). Regenerative strategies for kidney engineering FEBS Journal , 283, (18), 3303-3324
González, F., (2016). CRISPR/Cas9 genome editing in human pluripotent stem cells: Harnessing human genetics in a dish Developmental Dynamics , 245, (7), 788-806
Reddy, Pradeep, Ocampo, Alejandro, Suzuki, Keiichiro, Luo, Jinping, Bacman, Sandra , Williams, Sion, Sugawara, Atsushi, Okamura, Daiji, Tsunekawa, Yuji, Wu, Jun, Lam, David, Xiong, Xiong, Montserrat, Nuria, Esteban, Concepcion, Liu, Guang-Hui, Sancho-Martinez, Ignacio, Manau, Dolors, Civico, Salva, Cardellach, Francesc, del Mar O'Callaghan, Maria, Campistol, Jaime, Zhao, Huimin, Campistol, Josep, Moraes, Carlos, Izpisua Belmonte, Juan Carlos, (2015). Selective elimination of mitochondrial mutations in the germline by genome editing Cell 161, (3), 459-469
de Oñate, L., Garreta, E., Tarantino, C., Martínez, Elena, Capilla, E., Navarro, I., Gutiérrez, J., Samitier, J., Campistol, J.M., Muñoz-Cánovas, P., Montserrat, N., (2015). Research on skeletal muscle diseases using pluripotent stem cells Muscle Cell and Tissue (ed. Sakuma, K.), InTech (Rijeka, Croatia) , 333-357
- Real Time QuantStudio 5
- SimpliAmp thermocycler
- Eppendorf 5415D centrifuge
- Allegra X-15 R centrifuge
- Gyrozen 1248 centrifuge
- BioUltra 6 Telstar culture Hood 2x
- AH-100 Telstar primary culture Hood
- Binder CB 60 incubators 2x
- Controltecnica ASTEC SCA 165 incubator
- Controltecnica ZC 180 incubator
- Bioruptor Pico sonicator
- Thermomixer C thermal block
- Leica DMS1000 and DMIL Led microscopes
- Leica DMi1 microscope
- Leica MZ 10F magnifying glass
- Safe Imager 2.0 transilluminator
- Juan Carlos Izpisua Belmonte
Salk Institute for Biological Studies
- Dr. Josep Maria Campistol Plana
Experimental Laboratory of Nephrology and Transplantation, Hospital Clínic, Barcelona
- Peter Hohestein
The Roslin Institute, University of Edinburgh
- Dr. Pere Gascón Vilaplana
Head of Oncology Service/Molecular and Translational Oncology Laboratory, IDIBAPS
- Gloria Calderon
- Pura Muñoz Cánovas
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra
- Dr. Pedro Guillén
Director Clínica Cemtro, Madrid
- Dr. Francisco Fernández Avilés
Head of Cardiology Service, Hospital General Universitario Gregorio Marañón, Madrid
- Dr María Eugenia Fernández
Unit of Cell Production, Hospital Gregorio Marañón, Madrid
- Joaquin Gutiérrez Fruitós
University of Barcelona
- Dr. Pere Roca-Cusachs
- Dr. Elena Martínez
- Dr. Cristina Eguizabal Argaiz
Centro Vasco de Transfusion y Tejidos Humanos (CVTTH), Bizkaia
- Dr. Antonio Alcaraz
Head of Urology, Hospital Clínic, Barcelona
- Dr. Oriol Casanovas
Head of Tumour Angiogenesis Group, IDIBELL
Núria Montserrat, ICREA Research Professor at IBEC, appears in the media for her breakthrough between diabetes and COVID-19 thanks to human mini-kidneys created in the lab.
In an international collaboration, researchers led by Nuria Montserrat, ICREA Research Professor at IBEC, have generated human mini-kidneys that simulate the kidney of a person with diabetes in the early stages of the disease. These diabetic mini-kidneys open the door to studying, among others, the relationship between diabetes and COVID-19.
Núria Montserrat, principal investigator at the Institute for Bioengineering of Catalonia (IBEC), is featured in the newspaper “El País” for her work on the development of organoids through pluripotent stem cells that, in the future, could be used for transplants.
Núria Montserrat, principal investigator at IBEC, appears on RTVE’s “REPOR” program, where she talks about using mini-organs to identify new therapeutic therapies and new drugs.
The media have published the new discovery made by scientists from the Center for Genomic Regulation (CRG) and financed mainly by a CaixaResearch Health Research Project of the Fundació “la Caixa” awarded to Pia Cosma (CRG), Nuria Montserrat (IBEC) and Justin Christopher D’Antin (Barraquer).
Fusing human retinal cells with adult stem cells could be a potential therapeutic strategy to treat retinal damage and visual impairment, according to the findings of a new study published in the journal eBioMedicine, with participation of Nuria Montserrat´s Group at IBEC. The hybrid cells act by awakening the regenerative potential of human retinal tissue, previously only thought to be the preserve of cold-blood vertebrates.
Núria Montserrat, ICREA Research Professor and group leader at the Institute for Bioengineering of Catalonia (IBEC), appears in the media for her participation in the round table of the Barcelona Woman Acceleration Week 2022 (BWAW).
Núria Montserrat, leader of the IBEC Pluripotency for Organ Regeneration group appears in the ARA newspaper for the International Day of Women and Girls in Science.
Núria Montserrat, IBEC group leader and ICREA research professor, appears in the media for winning the “Premi Nacional de Recerca al Talent Jove” thanks to her pioneering work with mini-organs.
International experts and three hundred registered attendees met in the 14th IBEC Symposium, dedicated to regenerative therapies. Organised by the Institute for Bioengineering of Catalonia (IBEC), speakers presented the latest advances in mini-organs, organs on a chip, 3D bioprinting and tissue engineering, among others.
Nuria Montserrat, group leader at IBEC, is invited to the Onda Cero program “Más de uno”, where she shares her research with organoids to study diseases or replace damaged tissues and also explains the ability of the amphibian called axolotl to regenerate their own organs.
Last 23rd and 24th of June took place the European Research and Innovation Days, where Nuria Montserrat was invited to share her research and personal experiences in a high-level panel about “COVID-19: lessons learnt, preparedness and resilience”. The event was opened by Mariya Gabriel, European Commissioner for Innovation, Research, Culture, Education and Youth and was moderated chaired by Philip Campbell, Editor-in-Chief Springer Nature.
Nuria Montserrat, ICREA Research Professor and Group Leader at IBEC, has been awarded the National Research Award for Young Talent 2020 by the Catalan Government and the Catalan Foundation for Research and Innovation (FCRi). This award recognizes the pioneering research of Professor Montserrat in the field of bioengineering of pluripotent cells and generation of organoids, also known as mini-organs, for the study of diseases in humans.
Between the 8th and 13th June, the second edition of the “Barcelona City and Science Biennial” took place, and IBEC was one of the centers that contributed with its experts and the commissioner Nuria Montserrat. In addition, this Biennial culminated with the 14th edition of the Science Festival, with many proposals to live science in first person.
A 3-years research project led by the ICREA Research Professor at IBEC, Núria Montserrat, has been dedicated to study kidney cancer by using laboratory organoids, thanks to the “LAB 2017” grants from the Spanish Association Against Cancer (AECC). Researchers have managed to create the first renal organoid-based animal model for this type of cancer, and to identify early signs of the development of the disease.
Three projects of the Institute for Bioengineering of Catalonia (IBEC) will receive funding from “La Marató de TV3” to investigate different aspects of COVID-19. Thanks to the contributions received, the experts will deepen their understanding of the disease and its possible therapeutic solutions, study improvements in patient care processes, develop a system to predict the evolution of the respiratory system, and advance in the treatment of patients with pneumonia derived from COVID19.
Josep Samitier, Nuria Montserrat and Samuel Sánchez’s biobots appear in the National Geographic documentary “Ciencias de la vida: Trasplantes” for scientific innovation that addresses the growing demand for organs.
IBEC experts participate in the XIV Annual Conference of Biomedical Research Technology Platforms, focusing on research opportunities following the pandemic caused by COVID19. Josep Samitier, Teresa Sanchís and Nuria Montserrat highlight the advances made in nanomedicine and bioengineering for health, and join the voices that recommend increasing resources for the entire sector of basic and clinical research.
On the International Women’s Day, the Primary School “CEIP San Rafael” in Cádiz organized a series of activities with the aim of making the role of women in science more visible. Focusing on the figure of Nuria Montserrat, researcher ICREA at IBEC, and under the motto: “Nuria Montserrat: a woman of the future… and of the present,” the students honoured this scientist and recognized the work that, like her, is done by many researchers in our country.
Fourteen engineers, mathematicians, biologists and robotics experts warn of the need to break stereotypes and increase the presence of women in the STEM sector, which today generates the most employment.
Nuria Montserrat, group leader at IBEC, appears on the online platform “Women in Science and Innovation 2020” for highlighting its important work and contribution in the field of science and innovation in 2020.
Last Friday 5th of February, the Spanish Minister for Science and Innovation, Pedro Duque, visited the Institute for Bioengineering of Catalonia, in order to know first-hand the latest advances in bioengineering for health.
The Carlos III Health Institute grants Nuria Montserrat, ICREA Research Professor and principal investigator at the Institute for Bioengineering of Catalonia (IBEC), the coordination of the National Platform of Biobanks and Biomodels for the next three years.
Núria Montserrat, group leader at IBEC, is interviewed on the radio program “El Matí de Catalunya Ràdio” together with other researchers to talk about the prestige they have achieved based on their work in different scientific fields and whether the fact of being a woman has made it more difficult for them.
Núria Montserrat, ICREA researcher and IBEC group leader, appears in the podcast”Coronavirus Scientists” from “Agencia SINC” explaining how she managed during this past months both in the laboratory and at home, where she lives with her partner and three children.
Nuria Montserrat and her team at IBEC participates in an international consortium which aims to develop a new method to bring eyes back to life from deceased donors for clinical research purposes.
Researchers from the Institute for Bioengineering of Catalonia (IBEC), led by Dr. Nuria Montserrat, in collaboration with international researchers, have identified the genes that could protect the kidney from chronic damage. The identification was carried out using mini-kidneys created from human stem cells and generated in the laboratory using bioengineering techniques.
Nuria Montserrat, ICREA Research Professor and Group Leader at IBEC, has been awarded the prestigious “Consolidator Grant” from the European Research Council (ERC).
Nuria Montserrat has been selected to join EMBO, a prestigious network that brings together some of the most brilliant researchers in life sciences in the world. This year only 30 scientists have been selected among 216 candidates. The selected scientists will join the existing network of 73 current and 384 former members of the program.
The Institute for Bioengineering of Catalonia (IBEC) launches the Faster Future “A por la COVID19” campaign, with the aim of raising the 100.000€ needed to accelerate three research projects in collaboration with hospitals and patients associations.
Nuria Montserrat, ICREA professor and group leader at IBEC receives the “Constantes y Vitales” award for the best biomedical publication of 2020 for her work with human organoids created with bioengineering techniques for the study of SARS-CoV-2.
IBEC researcher Nuria Montserrat receives the “Constantes y Vitales” award for the best biomedical publication of 2020 for her work with human organoids created with bioengineering techniques for the study of SARS-CoV-2.
In a new review published in the prestigious scientific journal Nature Materials, IBEC experts discuss together with international experts from USA and Europe how bioengineering could be applied for the presentation of external inputs to better guide self-organisation and differentiation of human pluripotent stem cells (hPSCs) in order to generate higher-grade organoids
Núria Montserrat, group leader at IBEC is interviewed in the radio program “La poma de Newton” of Catalunya Ràdio talking about her research on the relationship between diabetes and Covid-19.
The Institute for Bioengineering of Catalonia (IBEC) organized from the 27th to the 28th October its 13th Symposium. The event, that this year took place for the first time online, was focused on Bioengineering for Future & Precision Medicine. With more than 400 registered attendees, 18 flash presentations and 106 posters, the event also counted with contributions from top international speakers such as Robert Langer from the MIT, Ada Cavalcanti of the University of Heidelberg or Raquel Yotti, Director of the Carlos III Health Institute, among others.
Nuria Montserrat and her research team at IBEC, receive funding from “Fundación BBVA” to lead a research project on COVID-19. Montserat’s project is one of the 20 projects selected from among almost 1,000 proposals submitted to the call, which will receive a total of 2.7 million euros. The twenty projects selected to stop the coronavirus outbreak involve more than 400 researchers, who will approach the mechanisms of infection, diagnosis and treatment of this disease from different angles. The psychosocial and economic impact derived from the pandemic will also be studied.
Emmanuelle Charpentier and Jennifer Doudna have been awarded the Nobel Prize in Chemistry 2020 for discovering a gene technology in Bioengineering: the CRISPR/Cas9 genetic scissors. The announcement marks the first time a science Nobel has been awarded to two women.
Yesterday took place the kick-off meeting of the european project MAD-CoV 2, in which participates the group led by ICREA Research Professor Núria Montserrat at IBEC.
Under the name of “Modern approaches for developing antivirals against SARS-CoV 2” (MAD-CoV 2) the project focuses on the development and delivery of therapeutic tools for the current COVID-19 outbreak.
International studies reveal that in the global health crisis women are doing less research, also in the coronavirus itself. Some of the reasons are the inequality in the housework distribution and the leadership distribution.
Researchers at the Institute of Bioengineering of Catalonia (IBEC) led by Núria Montserrat have found in vitro that diabetes is a disease that accelerates Covid-19. In the lab, they have also created mini-hearts to study the heart problems caused by Covid-19.
Nuria Montserrat, Group Leader at IBEC and ICREA Research Professor, meets with the Minister of Science and Innovation, Pedro Duque, to present her ACE2-ORG project, which seeks, by using organoids generated from bioengineering techniques, possible therapeutic solutions against the SARS-CoV-2 virus.
The Minister of Science and Innovation held a videoconference meeting this Thursday, June 18, with the responsibles of five research projects that are working on the development of new technologies to deal with SARS-CoV-2 and which are being financed by the Fund COVID-19, managed by the Carlos III Health Institute (ISCIII).
The Mayor of Barcelona, Ada Colau, visited IBEC facilities last Friday to learn, by our Director and a group of researchers, how bioengineering can help find solutions to health problems such as COVID19, cancer, or degenerative diseases.
When in early 2020, more than 200 scientists gathered in La Pedrera in Barcelona to discuss the present and future of bioengineering, no one imagined that the world would experience the first pandemic of the 21st century and that science would take on more importance than ever.
The COVID-19 Fund managed by the Carlos III Health Institute has awarded more than 300,000 euros to the “ACE2-ORG” project led by ICREA research professor Núria Montserrat at IBEC.The resources are intended to study COVID-19 and specify new therapeutic approaches against the SARS-CoV-2 coronavirus, the Karolinska Institute in Sweden, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, the Hospital Clínic de Barcelona and the University of Navarra also participate in this project.
ERC grantee Nuria Montserrat and her team create tiny kidneys which are proving to be key in the search for coronavirus drugs. The researcher is working with other international researchers and found that a trial drug could block early stages of COVID19. The ERC has created a section which is updated with the latest news about the ERC-funded research in coronavirus.
One of the most prestigious German newspapers, the Süddeutsche Zeitung echoes the work of Núria Montserrat and her international partners who are investigating with organoids a drug that blocks the entrance door of Covid19.
Nuria Montserrat, principal investigator of the “Pluripotency for organ regeneration” and her group have participated in an international study to find a treatment to stop the virus from continuing infecting other cells, preventing the virus from replicating.
IBEC researchers led by ICREA Research Professor Núria Montserrat, together with international collaborators, have identified a drug capable of blocking the effects of the SARS-Co-V2 virus, the origin of the Coronavirus 2019 disease.
The treatment, which can be tested on two hundred Covid-19 patients as of today, has proven effective in mini-kidneys generated from human stem cells. Using hese organoids generated by bioengineering techniques, it has been deciphered how SARS-Co-V2 interacts and infects human kidney cells.
Within the EU project BRAVƎ, experts at Institute for Bioengineering of Catalonia (IBEC) combine cell therapy and bioengineering to design a biological device that recovers cardiac functionality in people with cardiovascular diseases.
Researchers at IBEC led by the ICREA Professor Núria Montserrat contribute to the EU project BRAVƎ, an initiative for cardiac regeneration that combines cell therapy and bioengineering to design a biological device capable of recovering cardiac functionality in people with coronary heart disease.
Researchers at the Institute of Bioengineering of Catalonia (IBEC) led by Professor ICREA Núria Montserrat are studying the role of the receptor ‘Angiotensin converting enzyme’ (ACE2), one of the pathways that the SARS-Co-V2 virus uses to enter our body.
To do this, experts use mini-kidneys, as well as other cell cultures such as cardiac organoids. The goal is to exploit these mini-organs to better understand how the virus works.
Nuria Montserrat, principal investigator of the “Pluripotency for organ regeneration” spoke today at Espejo Público about the research that her group is carrying out in collaboration with other international research groups to find a treatment to stop the virus from continuing infecting other cells, preventing the virus from replicating.