About
Research in the laboratory focuses on developing nanoscale tools to study biological systems. These tools include instrumentation based on proximity probes, such as electrochemical tunnelling microscopy and spectroscopy and single molecule force spectroscopy, that we apply to investigate electron transfer in individual redox proteins, and other biophysical and biochemical interactions.
These studies are relevant to understand lipid membrane dynamics, to the development of biosensors and molecular electronics devices, and have led to the discovery of long-distance electrochemically gated electron transport between partner proteins of the respiratory and photosynthetic chains.
Another set of nanotools that we are developing is based on engineered molecular actuators that can be switched with light, such as azobenzene, which can be chemically attached to biomolecules in order to remotely control their activity (photopharmacology). They include peptide inhibitors of protein-protein interactions, small molecule enzymatic inhibitors, and photoswitchable ligands of a diversity of other proteins.
Among several applications, these compounds have enabled photoactivated chemotherapy, photocontrol of cellular signaling mediated by ion channels and G protein-coupled receptors, photocontrol of cardiac activity and locomotion, sensory restoration, and photocontrol of brain waves.
Based on these tools, we have also developed two-photon pharmacology to manipulate and study the activity of neurons and glia in intact brain tissue with pharmacological selectivity and sub-cellular three-dimensional resolution.
Staff
ibecbarcelona.euProjects
| INTERNATIONAL PROJECTS | FINANCER | PI |
|---|---|---|
| DEEPER · Deep Brain Photonic Tools for Cell-type specific targeting of Neural diseases (2021-2025) | European Commission, ICT | Pau Gorostiza |
| Human Brain Project Specific Grant Agreement 3 (2020-2023) | European Commission, FET FLAGSHIPS | Pau Gorostiza |
| NATIONAL PROJECTS | FINANCER | PI |
|---|---|---|
| DEEP RED · Neuromodulación de las vías inhibitorias mediante fotofarmacología activada por luz roja e infrarroja (2020-2023) | MINECO, Retos investigación: Proyectos I+D | Pau Gorostiza |
| PRIVATELY FUNDED PROJECTS | FINANCER | PI |
|---|---|---|
| Drug4Sight · Light-regulated drugs to restore sight (2019-2022) | Obra Social La Caixa | Pau Gorostiza |
| FINISHED PROJECTS | FINANCER | PI |
|---|---|---|
| DECA CECH · Cluster Emergente del Cerebro Humano (2019-2021) | RIS3CAT – Tecnologies Emergents | Pau Gorostiza |
| SGR Grups de recerca consolidats (2017-2020) | AGAUR / SGR | Pau Gorostiza |
| Q-SPET · Quantum-controlled Single Protein Electron Transport (2019-2020) | BIST Ignite Program | Pau Gorostiza |
| Human Brain Project Specific Grant Agreement 2 (2018-2020) | European Commission, FET FLAGSHIPS | Pau Gorostiza |
| FOCUS Single Molecule Activation and Computing | ICT | Pau Gorostiza |
| THERALIGHT Therapeutic Applications of Light-Regulated Drugs | ERC-PoC | Pau Gorostiza |
| Single-BioET Single-molecule junction capabilities to map the electron pathways in redox bio-molecular architectures (2012-2016) | MARIE CURIE – RG | Ismael Díez |
| Optogenetic pacemaking to rewire neural circuits | La Marató TV3 | Pau Gorostiza |
| OPTOPHARMACOLOGY Aplicaciones terapéuticas de la optofarmacología | MINECO (CTQ2013-43892-R) | Pau Gorostiza |
| Milk fat globule membrane and periphera proteins: lipid-protein interactions (2016-2017) | Fausto Sanz | INRA |
| WaveScalES Human Brain Project Specific Grant Agreement 1 (2016-2018) | European Commission, FET FLAGSHIPS | Pau Gorostiza |
| OPTOFRAX Optopharmacological brain mapping of autism mouse (2015-2017) | MARIE CURIE – IF | Miquel Bosch |
| NANOPROSTHETICS Prótesis moleculares para restablecer la visión basadas en fotoconmutadores covalentes dirigidos (2016-2019) | MINECO, Retos investigación: Proyectos I+D | Pau Gorostiza |
| MODULIGHTOR Moduladores fotoconmutables sintéticos para manipular remotamente proteínas endógenas: fotocontrol in vivo de canales iónicos pentaméricos (2015-2018) | MINECO Nacional /Acciones de Programación Conjunta Internacional | Pau Gorostiza |
| nanoET-leukemia Nanoconductance of electron transfer proteins of the respiratory chain. Direct measurement at the single molecular level and therapeutic regulation in cancer stem cells (2015-2018) | MINECO, Proyectos RETOS 2015 / CIBER | Marina Giannotti / Anna Lagunas |
| Inhibición fotoselectiva de interacciones proteína-proteína para el estudio de redes interactómicas y el desarrollo de nuevas terapias (2015-2018) | Pau Gorostiza | Fundación Ramon Areces |
| Fotoconmutadores covalentes para el control remoto de receptores endógenos (2017-2019) | Pau Gorostiza | Convocatoria de Ayudas a la Investigación FUNDALUCE |
Publications
Equipment
- iMic molecular imaging system
- Electrochemical scanning tunnelling microscope (STM) for molecular imaging
- Asylum Research Molecular Force Probe
- Multimode SPM Nanoscope III (SCT-UB)
- Autolab potentiostat
- Patch clamp setup with Heka EPC10 amplifier
- Molecular Imaging Electrochemical STM
Collaborations
- Prof. Amadeu Llebaria
Institut de Química Avançada de Catalunya (IQAC-CSIC) - Prof. Ernest Giralt
Dept. de Química Orgànica, Universitat de Barcelona - Prof. Miquel Àngel Pericàs
Institut Català d’Investigació Química (ICIQ), Tarragona - Dr. Piotr Bregestovski
Institut de Neurobiologie de la Mediterraneé (INMED), Marseille - Dr. Mireia Oliva
Dept. de Farmàcia i Tecnologia Farmacèutica, Universitat de Barcelona - Dr. Artur Llobet
Dept. Patología y Terapéutica Experimental, Universitat de Barcelona - Dr. Joan Torrent
Escola Universitària d’Òptica i Optometria de Terrassa, Spain - Prof. Dirk Trauner
Chemistry Dept., UC Berkeley, USA - Prof. Carles Solsona
Pathology and Experimental Therapeutics Dept, UB - Prof. Francisco Ciruela
ICREA / Universitat de Barcelona, Spain - Prof. Jesús Giraldo & Dr. Jordi Hernando
Universitat Autònoma de Barcelona, Spain - Niek van Hulst, Michael Krieg, Pablo Loza
Institut de Ciències Fotòniques (ICFO) - Carme Rovira
ICREA, Universitat de Barcelona - Pedro de la Villa
Universidad de Alcalá de Henares - Eduardo Fernández
Universitat Miguel Hernández - Burkhard König
Regensburg University - Michael Decker
Regensburg University - Elisabet Romero
Institut Català d’Investigació Química (ICIQ), Tarragona - Ismael Díez-Pérez
King’s College London - Andrea Barberis
Italian Institute of Technology - Roberta Croce
Vrije Universiteit Amsterdam - Gertrudis Perea
Instituto Cajal - Irene Díaz-Moreno, Miguel Ángel de la Rosa, Antonio Díaz-Quintana
Instituto de Investigaciones Químicas, Universidad de Sevilla - Joan Torrent
Escola Universitària d’Òptica i Optometria de Terrassa, Spain - Jordi Hernando, Ramon Alibés, Félix Busque, Josep Maria Lluch
Universitat Autònoma de Barcelona, Spain
News
First clinical mentoring for IBEC doctoral students in Barcelona hospitals
The Clinical Immersion Program for PhD students is an initiative Entrepreneurship Program of the IBEC and the College of Physicians of Barcelona (CoMB). Its objective is to connect IBEC doctoral … Read more
Postdoc2/ at the nanoprobes and nanoswitches Research Group
Postdoctoral / Deadline September 23th
Postdoc/ at the nanoprobes and nanoswitches Research Group
Postdoctoral / Deadline 23th September 2022
The first light-controlled drug that could improve the hearing of people with cochlear implants
Researchers at the Institute for Bioengineering of Catalonia (IBEC) in Spain and the University Medical Center Göttingen in Germany achieve, for the first time, in vivo light-activated auditory stimulation without the need for genetic manipulation. This new light-controlled drug, capable of triggering the neural pathways involved in hearing, can contribute to improving the spectral resolution of cochlear implants used by people with profound hearing loss or deafness.
ONCE visits IBEC to learn about the research in bioengineering for health
On February 15th, representatives of the National Organization of the Spanish Blind (ONCE) visited the Institute for Bioengineering of Catalonia (IBEC) to learn, first-hand and among others, about the innovative research work of Professor Pau Gorostiza’s Group in regenerative therapies of vision.
Controlling brain states with light
A study led by researchers from IBEC and IDIBAPS achieves, for the first time, the control of brain state transitions using a molecule responsive to light.
Controlling brain states with a ray of light
A study led by researchers from IBEC and IDIBAPS achieves, for the first time, the control of brain state transitions using a molecule responsive to light, named PAI. The results not only pave the way to act on the brain patterns activity, but they also could lead to the development of photomodulated drugs for the treatment of brain lesions or diseases such as depression, bipolar disorders or Parkinson’s or Alzheimer’s diseases.
New molecules allow to switch on and off neuronal circuits using light
Researchers from IBEC, in collaboration with an international team, describe the first molecules capable of regulate glycine receptors with light: Glyght and Azo-NZ1. The new molecules are a promising way to study neuronal circuits, to develop drug-based phototherapies non-invasively, and to understand neurological disorders related with the incorrect functioning of glycine receptors, as hyperekplexia, epilepsy and autism.
IBEC participates in European Project developing new technologies for the study and treatment of neurological diseases
Pau Gorostiza and his team at IBEC participates in the DEEPER project which aims at creating new tools for accessing the deep brain with unprecedented precision for the study and treatment of neurological diseases. The project involves 12 partners in 8 countries, and it has been funded by the European Union with approximately 5.7 million euros for the next 4 years.
New molecules developed in IBEC allow dilating the pupil with light
A study led by researchers from the ‘Nanoprobes and Nanoswitches’ Group of the Institute for Bioingeniería of Catalunya (IBEC) shows, for the first time, that the receptor proteins that control processes such as the pupil reaction can be regulated by light and new chemical compounds called “Adrenoswitches”.
Jobs
We are happy to receive CVs and enquiries from talented individuals. Prospective students and staff are encouraged to contact us to discuss possibilities. Please feel free to suggest new projects, areas of research or new ideas. You can visit the jobs page to find currents job openings in all IBEC groups or administration positions.
Postdoc2/ at the nanoprobes and nanoswitches Research Group
Postdoctoral / Deadline September 23th
Postdoc/ at the nanoprobes and nanoswitches Research Group
Postdoctoral / Deadline 23th September 2022