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IRB Research Node/IBEC Joint Seminar: Jolanda van Leeuwen
Wednesday, January 18, 2023 @ 12:00 pm–2:00 pm
Date: Wednesday 18 January 2023, 12:00h
Place: Audiorium Room, PCB
Speaker: Jolanda van Leeuwen, University of Lausanne, Lausanne, Switzerland
Title: Systematic analysis of genetic suppression interactions
Host: Patrick Aloy (IRB) & Benedetta Bolognesi (IBEC)
Abstract:
Recent genome sequencing efforts have identified people that are healthy despite carrying mutations that have been directly associated with severe early-onset Mendelian diseases. These resilient individuals may carry secondary mutations elsewhere in the genome that can compensate for the deleterious effect of the disease-associated mutation, a phenomenon referred to as genetic suppression. Identification of the protective mutations could highlight strategies for therapeutic intervention, but we currently lack the expertise to identify the suppressor mutations among the millions of variants scattered across the genomes of resilient individuals.
I will discuss how we use systematic genetic suppression interaction screens in the budding yeast and cultured human cells to dissect gene function and pathway connectivity, and to define conserved properties of genetic suppression that we can use to predict suppression interactions between genomic variants across species.
