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PhD Thesis Defence: Ana López Mengual
Wednesday, January 12, 2022 @ 11:30 am–1:30 pm
Factores físicos y moleculares implicados en la migración celular y en el desarrollo de la corteza cerebral.
Ana López Mengual, Molecular and cellular neurobiotechnology group
Abstract
Cell migration acquires special relevance during embryonic development and tissue regeneration. During the development of the adult individual, cells multiply, differentiate and mature, having to move to their destination regions through migration. Once the adult individual has formed, these tissues can suffer damage, leading to an altered state. In this process of tissue regeneration, they try to set tissue homeostasis, cell migration is essential. This thesis analyses the mechanical factors involved in cell migration in brain development and neural regeneration, as a fundamental tool to understand these processes. OECs migrate greater distances over CXCL12 functionalized PLA 80/20 nanofibers, thus responding to the chemotactic gradient. Measurements made with by means of BIO-AFM of the mouse embryonic brain reveals differences between the pallium and the subpallium. These differences determine the differential migration rates when transplanting explants of various origins outside their usual site and analysing the migration of Cajal-Retzius cells. In addition, Cajal-Retzius cells respond by calcium entry to the inhibition of mechanosensitive cation channels, changing their migration rate. So, we conclude that physical factors are a key factor involved in the migration and disposition of Cajal-Retzius cells.
The public event will take place at the Sala de Graus at the Faculty of Biology (University of Barcelona) on January 12th at 11:30. If you prefer to attend to this defence virtually, contact with Ana López (alopezm@ibecbarcelona.eu).
