Nuclear mechanobiology – from striated muscle disease to ultrarapid cellular mechanosensing Jan Lammerding, PhD, Weill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA Abstract. The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is investigating ... Read more

Developability assessment of biologics and formulation of novel molecules Shahid Uddin, PhD, MBA, Senior Director of Drug Product, Formulation & Stability within the CMC department at Immunocore, UK It’s vital to ensure appropriate assessment of molecules at the early research phase is carried out to risk mitigate movement into the development phase. This ensures the best risk ... Read more

Nanomedicine to Tackle Unmet Medical Needs in CNS Disorders Sabina Quader, Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki, Kanagawa 210-0821 Japan The brain is undoubtedly the body's most essential and intricate organ, and brain disorders are closely tied to this intricacy. Categorized as "CNS diseases," a wide range of brain-related conditions - ... Read more

Semi-synthetic nucleosomes to stabilize and image enzyme-chromatin interactions Carlos Moreno Yruela, Researcher in Chemical Biology, EPFL, Switzerland Chromatin structure regulates gene expression and is tightly controlled by histone post-translational modifications. SIRT7 is a histone lysine deacylase found to maintain oncogenic gene expression profiles supporting tumor growth and metastasis. Interestingly, the activity of SIRT7 is fully ... Read more

Harnessing the power of stem cell therapy in an off-the-shelf nano-delivery platform for treating brain disorders Prof Marcelle Machluf, Faculty of Biotechnology and Food Engineering, Technion, Haifa, Israel Mesenchymal stem cells (MSCs) have gained the most attention in cell therapy, owing to their ability to traverse physiological barriers, and target different sites of inflammation including ... Read more