Beating Organs-on-Chip: leveraging on motion to mimic human organ physiological/diseased states in vitro Erika Ferrari, Commercial Science Leader, BiomimX Srl Beating Organs-on-Chip are in vitro miniaturized models developed within the uBeat® platform, which integrates microfluidics, 3D human cell culture and controlled mechanical stimulation to recapitulate, with unprecedented precision and predictability, clinically relevant models reflective of ... Read more

Single molecule insights into cellular mechanotransduction Sergi Garcia-Manyes, Single Molecule Mechanobiology laboratory, The Francis Crick Institute and King’s College London   Cellular mechanostransduction relies on the conversion of mechanical cues into chemical signals, which propagate from the focal adhesion hub through the cytoskeleton to ultimately reach the nucleus through the Nuclear Pore Complex (NPC), and ... Read more

Engineering the Nanoscale Membrane Topography in Cells Wenting Zhao, School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore and Institute for Digital Molecular Analytics and Science (IDMxS), Singapore  Abstract. Cell membranes serve as a central platform to host a variety of proteins essential for cellular activities such as cell signaling, morphogenesis, and membrane ... Read more

Enhanced regeneration through in vivo cell reprogramming: lessons from the first decade of research and a success story in the mouse heart Irene de Lázaro, PhD1,2,3 1 Department of Biomedical Engineering, NYU Tandon School of Engineering, New York University 2 Cardiovascular Research Center, NYU School of Medicine and NYU Langone Health 3 Harvard John A ... Read more

Nuclear mechanobiology – from striated muscle disease to ultrarapid cellular mechanosensing Jan Lammerding, PhD, Weill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA Abstract. The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is investigating ... Read more