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IBEC-IFIBYNE Webinar Cycle (online) 12th July 2023 at 16:00 Javier Ramon

Wednesday, July 12, 2023 @ 4:00 pm5:00 pm

Organ on a chip models to emulate multi systemic metabolic diseases

Javier Ramon, IBEC

Existing on-chip tissue models typically represent a single organ, limiting systemic drug investigations. Microscale tissue analog systems aim to improve drug and toxicity predictions across various organs. However, multi-organ devices are limited, and none have explored skeletal muscle and pancreatic islets. We developed a novel multi-organ-on-a-chip platform for real-time, sensitive monitoring of cross-talk between two organs. Unlike previous electrochemical platforms, our sensing system offers cost-effectiveness, label-free detection, easy integration, multiplexing, and real-time monitoring. This platform quantifies secreted proteins with high sensitivity, crucial for understanding the relationship between skeletal muscle and the pancreas. Our work shows promise for disease modeling, drug screening, and personalized medicine.

Doctor Javier Ramon is an ICREA Professor since 2021 and the leader of the Biosensors for Bioengineering group at the Institute of Bioengineering of Catalonia. Javier studied Chemistry at the University of Catalonia and completed his PhD at the CSIC in the Institute of Advanced Chemistry of Catalonia. He conducted his postdoctoral research in Japan at the Advanced Institute of Materials and returned to Spain in 2016 as a Ramon y Cajal researcher. His research is focused on tissue engineering, biomaterials, biosensors, and integrating these technologies into organ-on-chip devices to study diseases and drug screening.