The effect of gene loss on adaptation | 3D cell shape analysis in embryos
Rob Jelier, CMPG – Predictive Genetics and Multicellular Systems University of Leuven
In this talk I will summarize two research projects. First, I will report on a large-scale experimental evolution study into the effect of gene deletion on adaptation. We found gene deletion can speed up adaptation. Further, tracking adaptation after the systematic perturbation of genes involved in a complex trait informs on the genetic architecture of the trait. Second, we have developed a segmentation-pipeline for membrane tagged cells from fluorescent microscopy timelapses. The pipeline uses a biophysical DEM model of cell shape to constrain the possible cell shapes. The retrieved accurate cell shapes are subsequently used for very sensitive characterization of cell shapes, for example to identify changes after perturbations.
This seminar will be held at Tower I, 11th floor Baobab room, there will be 30 avialable seats, the free spots will be assigned on a first come first served basis. If you wish to attend this seminar online, please write to firstname.lastname@example.org.