By optimising and combining these constructs appropriately, the groups of Pere Roca-Cusachs and Xavier Trepat at IBEC aim to develop light-emitting sensors that measure nuclear mechanosensing by monitoring their nuclear localisation. This is part of an ambitious project funded by the CaixaResearch Health Call of “la Caixa” Foundation.
When tumour cells invade the organs and metastasis occurs, for instance, they generate physical forces that are transmitted all the way to the cell nucleus. These forces drastically affect gene expression and drive the progression of the disease.
Pere Roca-Cusachs
When tumour cells invade the organs and metastasis occurs, for instance, they generate physical forces that are transmitted all the way to the cell nucleus. These forces drastically affect gene expression and drive the progression of the disease.You can read the impacts in the media here:
