The intestinal organoids hit the media

The group led by Xavier Trepat at IBEC, together with Marino Arroyo, associate researcher at IBEC, and other international collaborators have developed intestinal organoids and measured cellular forces in order to decipher how the inner wall of this vital organ folds and moves.

Read more…

Mechanical forces, half of the alphabet to understand life

Xavier Trepat and international experts remind us in a piece published in the Journal Nature by science writer Amber Dance, the crucial role of physics in order to understand biological entities such cells and organs, both in health and disease. In words of Trepat: “Understanding a cell without physics is like trying to write a book with only half the letters of the alphabet”.

Read more…

Bioengineering against cancer

Xavier Trepat and Pere Roca-Cusachs, group leaders at IBEC, appear on the journal “ABC” explaining their research project that they will carry out thanks to funding from “la Caixa” as part of the «Health Research Call ».

Read more…

Bioengineering against cancer: IBEC researchers receive funding from La Caixa

IBEC researchers Elena Martínez, Xavier Trepat and Pere Roca-Cusachs aim to understand the processes that promote metastasis in colorectal cancer using innovative bioengineering tools, such as bioprinting and microscopy capable of revealing forces at the cellular level.

The results will be translated into a device that will recreate the tumor environment from cancer cells derived from patients, as well as a new technology that will allow to visualize how physical forces affect the nuclei of metastatic cells.

Read more…

How can we measure mechanical stress in living tissues?

A team of experts from the Institute for Bioengineering of Catalonia (IBEC) has published a review in the journal Nature Reviews Physics detailing the different techniques used to calculate mechanical stress in tissues, both in cell cultures and in vivo. Determining these mechanisms of mechanical stress is crucial to study processes linked to morphogenesis, homeostasis, and diseases such as cancer.

In order to work properly, living tissues need to continuously move, divide, reshape and perceive their microenvironment. In other words, they need to withstand certain mechanical stress derived from contact.

Read more…

IBEC researchers explain “Durotaxis”, a cell migration mechanism with a potential role in several diseases

Xavier Trepat, group leader of the “Integrative cell and tissue dynamics” at IBEC together with Raimon Sunyer, Senior researcher in Trepat’s lab, have written a Primer in Current Biology magazine on “Durotaxis”, a cell migration mechanism that might have a role in several disease states that include the stiffening of tissues.

Embryo development, tumour progression or the immune response against pathogens requires cell migration.

Read more…