by Keyword: In-vivo imaging

Mouloudakis, K, Bodenstedt, S, Azagra, M, Mitchell, MW, Marco-Rius, I, Tayler, MCD, (2023). Real-Time Polarimetry of Hyperpolarized 13C Nuclear Spins Using an Atomic Magnetometer Journal Of Physical Chemistry Letters 14, 1192-1197

We introduce a method for nondestructive quantification of nuclear spin polarization, of relevance to hyperpolarized spin tracers widely used in magnetic resonance from spectroscopy to in vivo imaging. In a bias field of around 30 nT we use a high-sensitivity miniaturized 87Rb-vapor magnetometer to measure the field generated by the sample, as it is driven by a windowed dynamical decoupling pulse sequence that both maximizes the nuclear spin lifetime and modulates the polarization for easy detection. We demonstrate the procedure applied to a 0.08 M hyperpolarized [1-13C]-pyruvate solution produced by dissolution dynamic nuclear polarization, measuring polarization repeatedly during natural decay at Earth's field. Application to real-time and continuous quality monitoring of hyperpolarized substances is discussed.

JTD Keywords: performance, polarization, Atomic magnetometers, Bias field, High sensitivity, Hyperpolarized, In-vivo imaging, Magnetic resonance, Magnetic-resonance, Magnetic-resonance,polarizatio, Magnetic-resonance,polarization,performanc, Magnetometers, Non destructive, Nuclear spins, Nuclear-spin polarization, Rb vapors, Real- time, Spin dynamics, Spin polarization