by Keyword: Reduced inequalities
Fortunato, IC, Sunyer, R, (2022). The Forces behind Directed Cell Migration Biophysica 2, 548-563 
Directed cell migration is an essential building block of life, present when an embryo develops, a dendritic cell migrates toward a lymphatic vessel, or a fibrotic organ fails to restore its normal parenchyma. Directed cell migration is often guided by spatial gradients in a physicochemical property of the cell microenvironment, such as a gradient in chemical factors dissolved in the medium or a gradient in the mechanical properties of the substrate. Single cells and tissues sense these gradients, establish a back-to-front polarity, and coordinate the migration machinery accordingly. Central to these steps we find physical forces. In some cases, these forces are integrated into the gradient sensing mechanism. Other times, they transmit information through cells and tissues to coordinate a collective response. At any time, they participate in the cellular migratory system. In this review, we explore the role of physical forces in gradient sensing, polarization, and coordinating movement from single cells to multicellular collectives. We use the framework proposed by the molecular clutch model and explore to what extent asymmetries in the different elements of the clutch can lead to directional migration.
JTD Keywords: Cell migration, Cell traction forces, Chemotaxis, Contact guidance, Curvotaxis, Cytoskeleton, Durotaxis, Extracellular-matrix, Focal adhesions, Guidance, Haptotaxis, Leading-edge, Mechanotaxis, Membrane tension, Molecular clutch model, Myosin-ii, Reduced inequalities, Rigidity, Stress fibers, Traction
Verschure PFMJ, (2022). Healing the Virtualizing Brain Using Virtual Reality: How Goal-Oriented, Embodied, Immersive VR Training Works Biosystems And Biorobotics 28, 575-578
This paper analyzes the question what the principles are behind the success of the Rehabilitation Gaming System in the treatment of functional deficits post stroke. The hypothesis is that by projecting the recovering brain in a virtual task space adhering to basic ecological parameters such as embodiment, the forward models underlying voluntary action are optimally driven to functionally reorganize. This virtualization hypothesis is further linked to the Distributed Adaptive Control theory of mind and brain and specific results obtained with intracranial epilepsy patients and the detailed study of motor control. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
JTD Keywords: Reduced inequalities
Alert R, Trepat X, (2021). Living cells on the move Physics Today 74, 30-36
