by Keyword: Wheeze

Cereta, AD, Oliveira, VR, Costa, IP, Guimaraes, LL, Afonso, JPR, Fonseca, AL, de Sousa, ART, Silva, GAM, Mello, DACPG, de Oliveira, LVF, da Palma, RK, (2021). Early Life Microbial Exposure and Immunity Training Effects on Asthma Development and Progression Frontiers Of Medicine 8, 662262

Asthma is the most common inflammatory disease affecting the lungs, which can be caused by intrauterine or postnatal insults depending on the exposure to environmental factors. During early life, the exposure to different risk factors can influence the microbiome leading to undesired changes to the immune system. The modulations of the immunity, caused by dysbiosis during development, can increase the susceptibility to allergic diseases. On the other hand, immune training approaches during pregnancy can prevent allergic inflammatory diseases of the airways. In this review, we focus on evidence of risk factors in early life that can alter the development of lung immunity associated with dysbiosis, that leads to asthma and affect childhood and adult life. Furthermore, we discuss new ideas for potential prevention strategies that can be applied during pregnancy and postnatal period.

JTD Keywords: asthma, dysbiosis, early life immunity, lung microbiome, Adulthood, Antibiotic exposure, Asthma, Childhood, Disease, Disease exacerbation, Dysbiosis, Early life immunity, Gut microbiome, Human, Immunity, Intestine flora, Lung development, Lung microbiome, Lung microbiota, Nonhuman, Perinatal period, Pregnancy, Prevention, Prevention strategies, Review, Risk, Risk factor, Sensitization, Supplementation, Vitamin-d, Wheeze

Lozano-Garcia, M., Fiz, J. A., Jané, R., (2014). Analysis of normal and continuous adventitious sounds for the assessment of asthma IFMBE Proceedings XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013 (ed. Roa Romero, Laura M.), Springer International Publishing (London, UK) 41, 981-984

Assessment of asthma is a difficult procedure which is based on the correlation of multiple factors. A major component in the diagnosis of asthma is the assessment of BD response, which is performed by traditional spirometry. In this context, the analysis of respiratory sounds (RS) provides relevant and complementary information about the function of the respiratory system. In particular, continuous adventitious sounds (CAS), such as wheezes, contribute to assess the severity of patients with obstructive diseases. On the other hand, the intensity of normal RS is dependent on airflow level and, therefore, it changes depending on the level of obstruction. This study proposes a new approach to RS analysis for the assessment of asthmatic patients, by combining the quantification of CAS and the analysis of the changes in the normal sound intensity-airflow relationship. According to results obtained from three patients with different characteristics, the proposed technique seems more sensitive and promising for the assessment of asthma.

JTD Keywords: Asthma, Bronchodilator response, Continuous adventitious sound, Respiratory sound intensity, Wheezes