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by Keyword: Women
Roncero-Carol, Joan, Olaizola-Munoa, June, Aran, Begona, Cuesta, Marta Miret, Blanco-Cabra, Nuria, Casals, Marc, Rumbo, Mireia, Inarejos, Miquel Sole, Ojosnegros, Samuel, Alsina, Berta, Torrents, Eduard, Irimia, Manuel, Hoijman, Esteban, (2025). Epithelial cells provide immunocompetence to the early embryo for bacterial clearance Cell Host & Microbe 33, 1106-1120 
Early embryos are exposed to environmental perturbations that may influence their development, including bacteria. Despite lacking a proper immune system, the surface epithelium of early embryos (trophectoderm in mammals) can phagocytose defective pluripotent cells. Here, we explore the dynamic interactions between early embryos and bacteria. Quantitative live imaging of infection models developed in zebrafish embryos reveals the efficient phagocytic capability of surface epithelia in detecting, ingesting, and destroying infiltrated E. coli and S. aureus. In vivo single-cell interferences uncover actin-based epithelial zippering protrusions mediating bacterial phagocytosis, safeguarding developmental robustness upon infection. Transcriptomic and inter-scale dynamic analyses of phagocyte-bacteria interactions identify specific features of this epithelial phagocytic program. Notably, live imaging of mouse and human blastocysts supports a conserved role of the trophectoderm in bacterial phagocytosis. This defensive role of the surface epithelium against bacterial infection provides immunocompetence to early embryos, with relevant implications for understanding failures in human embryogenesis.
JTD Keywords: Embryo, Gene-expression, Highlights, Microbial colonization, Modulation, P, Phagocytosis, Rho, Women
Ye, Z, Qi, YP, Zhang, AQ, Karels, BJ, Aparicio, C, (2023). Biomimetic Mineralization of Fibrillar Collagen with Strontium-doped Hydroxyapatite ACS Macro Letters 12, 408-414
Fibrillar collagen structures mineralized with hydroxyapatite using the polymer-induced liquid precursor (PILP) process have been explored as synthetic models for studying biomineralization of human hard tissues and have also been applied in the fabrication of scaffolds for hard tissue regeneration. Strontium has important biological functions in bone and has been used as a therapeutic agent for treating diseases that result in bone defects, such as osteoporosis. Here, we developed a strategy to mineralize collagen with Sr-doped hydroxyapatite (HA) using the PILP process. Doping with Sr altered the crystal lattice of HA and inhibited the degree of mineralization in a concentration-dependent manner, but did not affect the unique formation of intrafibrillar minerals using the PILP. The Sr-doped HA nanocrystals were aligned in the [001] direction but did not recapitulate the parallel alignment of the c-axis of pure Ca HA in relation to the collagen fiber long axis. The mimicry of doping Sr in PILP-mineralized collagen can help understand the doping of Sr in natural hard tissues and during treatment. The fibrillary mineralized collagen with Sr-doped HA will be explored in future work as biomimetic and bioactive scaffolds for regeneration of bone and tooth dentin.
JTD Keywords: bone regeneration, osteoblast differentiation, osteoporosis, ranelate, risk, scaffolds, women, Intrafibrillar mineralization
