by Keyword: Wound dressing
Castrejon-Comas, Victor, Mataro, Nil, Resina, Leonor, Zanuy, David, Nunez-Aulina, Quim, Sanchez-Moran, Joel, Enshaei, Hamidreza, Arnau, Marc, Munoz-Galan, Helena, Worch, Joshua C, Dove, Andrew P, Aleman, Carlos, Perez-Madrigal, Maria M, (2025). Electro-responsive hyaluronic acid-based click-hydrogels for wound healing Carbohydrate Polymers 348, 122941
With the aim of healing challenging skin wounds, electro-responsive click-hydrogels made of hyaluronic acid (clickHA) crosslinked with a modified polyethylene glycol precursor (PEG) were prepared by semi- interpenetrating a conducting polymer, poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PEDOT-MeOH) by oxidative polymerization. The porosity and pore size of the mixed hydrogel, clickHA/PEDOT-MeOH, were both higher than those determined for the hydrogel without PEDOT-MeOH, while a honeycomb-like morphology with PEDOT-MeOH covering the pore walls was observed. Although such PEDOT-MeOH-induced changes did not influence the water absorption capacity of clickHA, they drastically affected the mechanical and electrochemical behavior. More specifically, the semi-interpenetration of PEDOT-MeOH into clickHA resulted in an increase of the Young's modulus, the compressive strength and, especially, the electrochemical activity. The biocompatibility and the potential for skin regeneration of clickHA/PEDOT-MeOH were preliminary assessed using viability and wound-healing assays with epithelial cells. Not only is the conducting hydrogel formulation biocompatible, but also promotes efficient cell migration by electrostimulation using a small voltage (0.5 V) for a short time (15 min). Thus, in just 1 h the wound gap was repaired, and a homogeneous monolayer of migrated cells was formed.
JTD Keywords: 4-ethylenedioxythiophene, Car, Click hydrogel, Conducting polymer, Hyaluronic acid, Poly(3, Proliferation, Rational design, Scaffold, Skin, Wound dressing
