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Biomaterials as signal-releasing platforms

IBEC’s Biomaterials for Regenerative Therapies group has published a review of the state-of-the-art in biomaterials for skin healing that proposes a move towards more personalized, in situ therapies.

Skin wound healing repairs and restore tissue through a complex process that involves different cells and signalling molecules that regulate cellular response and the remodelling of the extracellular matrix. Publishing in Advanced Drug Delivery Reviews, the article begins by summarizing recent advances in therapies for healing that combine biomolecule signals such as growth factors and cytokines with cells.

A material that encourages blood vessels to form

In a further step forward in their quest to achieve functional biomaterials for tissue regeneration, IBEC’s Biomaterials for Regenerative Therapies group has revealed a new construct that enhances blood vessel formation and maturation in vivo.

In the paper published in Acta Biomaterialia at the end of last year, the group and their collaborators at the Georgia Institute of Technology present a new implantable hydrogel that contains both human mesenchymal stromal cells (hMSCs) and calcium-releasing microparticles.