A paper by IBEC’s Smart nano-bio-devices group addresses the problem of biofilms, the “microbe cities” that enhance cell-to-cell communication for bacteria, allowing infection to thrive and increasing the chances of evading the immune system. In the body, they can be found in a wide variety of microbial infections, such as in the lungs of cystic fibrosis or chronic obstructive pulmonary disease patients.
Biofilm colonies are usually resistant to antibiotics and require targeted methods of removal. One method uses nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. These are not very effective, however, as they need to be able to get much closer to the biofilm.