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Unexpected discovery about the ways cells move could boost understanding of complex diseases

A new discovery about how cells move inside the body may provide scientists with crucial information about disease mechanisms such as the spread of cancer or the constriction of airways caused by asthma.

Researchers at IBEC and Harvard School of Public Health have found that epithelial cells—the type that form a barrier between the inside and the outside of the body, such as skin cells—move in a group, propelled by forces both from within and from nearby cells to fill any spaces they encounter.

Cells play ‘tag’ to determine direction of movement

Researchers at IBEC, the University of Barcelona and their collaborators have found that cells in our bodies, when moving collectively, carry out something similar to a game of ‘tag’ to coordinate their movement in a particular direction.

The scientists in Barcelona and London looked at cells in the neural crest, a very mobile embryonic structure in vertebrates that gives rise to most of the peripheral nervous system and to other cell types in the cardiovascular system, pigment cells in the skin, and some bones, cartilage, and connective tissue in the head.