About
The Bacterial infections: antimicrobial therapies group is a junior group under IBEC’s Tenure Track scheme.
Infectious diseases constitute a tenacious and major public health problem all over the world. The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches.
Biofilms are bacterial communities that grow embedded within a protective matrix produced by themselves.
Also, chronic infections caused by bacteria growing in biofilms, are enormously complicated to treat. It increases their fitness and survival, thus complicating treatment and diagnosis because they persist despite the action of antibiotic therapies and adaptive immune responses.
Over 60% of all human infections are characterized by the formation of a biofilm, which is involved in a wide variety of pathological conditions by either growing over human tissues (Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, chronic wound, etc.) or by developing on the surfaces of medical devices (e.g. endotracheal tubes, intravenous and urinary catheters, etc.).
Our lab aims to investigate new antimicrobial therapies and strategies to combat bacterial infections with different objectives:
- The use of nanomedicine techniques for the development of novel and specific nanoparticles to deliver existing antibiotics or new identify antimicrobial drugs, significantly when the bacteria are growing in biofilm, close to the physiological conditions of the disease and where the current chemotherapy fails;
- The identification and screening of new molecules for the highly selective inhibition of new antibacterial targets (e.g. ribonucleotide reductases);
- The use of nanomedicine techniques for the development of novel and specific nanoparticles to deliver existing antibiotics or new identify antimicrobial drugs, significantly when the bacteria are growing in biofilm, close to the physiological conditions of the disease and where the current chemotherapy fails;
- To study new methodologies to treat chronic bacterial infections in patients suffering cystic fibrosis;
- To develop a new family of antibacterial vaccines;
- The development of new strategies for bacterial coculture systems;
- To study and develop models for wound healing infections and the search of novel treatments;
- The use of lab-on-a-chip technology to deeply elucidate mechanisms to combat bacterial forming biofilm as well as new approaches to identify multiresistant bacteria to different antibiotics.
- To establish the molecular basis for the regulation of genes involved in DNA synthesis (ribonucleotide reductase genes), their importance in virulence and biofilm formation;
We believe these projects will be beneficial to society since we explore the use of different bioengineering approaches to elucidate ways to diagnose and eradicate multi-drug resistant bacteria.
Related links:
Staff
ibecbarcelona.euFormer Members
Maria del Mar Cendra | PhD Student
Projects
| NATIONAL PROJECTS | FINANCER | PI |
|---|---|---|
| InfectTreat · Understanding DNA metabolism and new insights in polymicrobial biofilms: development of more efficient therapies to tackle bacterial infections (2022 – 2025) | MICIU. Generación Conocimiento proyectos I+D | Eduard Torrents |
| DISnanoAMR · Desarrollo de nuevas estrategias para hacer frente a la resistencia antibiótica (2022 – 2025) | MICIU. Poryectos de I+D+i en líneas estratégicas | Eduard Torrents |
| IVD-Biofilm · Desarrollo de un nuevo dispositivo para el diagnóstico personalizado en infecciones relacionadas con biopelículas (2022 – 2024) | MICIU. Proyectos Pruebas de Concepto | Eduard Torrents |
| Acuerdo de colaboración ente el IBEC y la Asociación Catalana de Fibrosis Quística (2019 – 2024) | Asociación Catalana de Fibrosis Quística | Eduard Torrents |
| Las biopelículas polimicrobianas para el desarrollo de terapias más eficientes contra las infecciones bacterianas” (2021-2022) | Diputació de Barcelona | Eduard Torrents |
| combatRNR · Comprender la síntesis del ADN en patógenos bacterianos: nuevas estrategias para el tratamiento de enfermedades infecciosas (2019 – 2022) | MICIU. Retos investigación: Proyectos I+D | Eduard Torrents |
| BIOVAC · Artificial bacteria: a novel generation of bioinspired vaccines (2020 – 2023) | BIST. BIST Ignite Program | Eduard Torrents |
| Las biopelículas polimicrobianas para el desarrollo de terapias más eficientes contra las infecciones bacterianas” (2021-2022) | Diputació de Barcelona | Eduard Torrents |
| FINISHED PROJECTS | FINANCER | PI |
|---|---|---|
| Terapias alternativas para el tratamiento de las infecciones bacterianas crónicas en pacientes con fibrosis quística a (2019-2021) | Asociación Catalana de Fibrosis Quística | Eduard Torrents |
| Noves estratègies antimicrobianes per combatre la fibrosi quística (2016-2020) | Obra Social La Caixa | Eduard Torrents |
| BiofilmChip CaixaImpulse BiofilmChip (2018 – 2020) | Obra Social La Caixa | Eduard Torrents |
| Desarrollo de una nueva familia de compuestos antimicrobianos | Asociación Catalana de Fibrosis Quística | Eduard Torrents |
| Identificación y administración de nuevas moléculas antimicrobianas contra Pseudomonas aeruginosa creciendo en biofilm | Asociación Española Fibrosis Quística, Becas de Investigación “Pablo Motos” | Eduard Torrents |
| Novel strategies to combat bacterial chronic infections by the development of microfluidics platforms to analyse and treat bacterial growing in biofilms (2016) | Obra Social La Caixa | Eduard Torrents |
| Redes reguladoras de la expresión génica de las distintas ribonucleotidil reductasas en bacterias | MINECO, I+D-Investigación fundamental no orientada | Eduard Torrents |
| BACTSHOT Novel antimicrobial therapy (2016-2017) | EIT Health Head Start – Proof of Concept | Eduard Torrents |
| inhibitRNR Las ribonucleotido reductasas como una nueva diana terapéutica frente a patógenos bacterianos (2016-2018) | MINECO, Retos investigación: Proyectos I+D | Eduard Torrents |
| Ribonucleotide reductasas: una nueva diana terapéutica contra organismos patógenos en enfermos de fibrosis quística (2010-2017) | Asociación Española Fibrosis Quística, Becas de Investigación “Pablo Motos” | Eduard Torrents |
| RNRbiotic New strategy to combat bacterial infections (2015-2017) | Obra Social La Caixa, Caixaimpulse | Eduard Torrents |
Publications
(See full publication list in ORCID)
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Equipment
- Zeiss LSM 800 Confocal Laser Scanning Microscope
- Nikon Inverted Fluorescent microscope ECLIPSE Ti-S/L100
- Cell culture facilities for microbial infections
- Characterization of nanoparticles/biomaterial antibacterial activity
- Drosophila melanogaster and Galleria mellonella as a model host for bacterial infections
- Continuous flow system model for bacterial biofilm development
- Single Channel Fiber-Optic Oxygen Meter with microsensor
- Molecular biology, biochemistry and protein purification facilities
- Bacterial expression systems for heterologous protein production
Collaborations
- Prof. Fernando Albericio
Institut de Recerca Biomèdica (IRB), Barcelona, Spain - Dr. Elisabeth Engel
IBEC - Dr. Esther Julián
Dept. de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Spain - Dr. Joan Gavaldà
Infectious diseases, Vall d’Hebrón Hospital and Research Institute, Barcelona, Spain - Prof. Víctor Puntes
Inorganic nanoparticles group, Institut Català de Nanociència i Nanotecnología, Barcelona, Spain - Prof. Josep Samitier
IBEC - Prof. Santiago Vazquez
Laboratori de química farmacèutica, Pharmacy Faculty, Barcelona University - Prof. Gabriel Gomila
IBEC - Prof. Vladimir Arion
Department of Inorganic Chemistry, University of Vienna, Austria - Dr. Maria Teresa Martin-Gomez
Division of Respiratory Bacteriology and Clinical Mycology. Microbiology Department. Vall d’Hebrón Hospital, Spain
News
A molecular mechanism could explain how bacteria resist antibiotics
IBEC researchers have shown for the first time how bacteria make DNA under stressful conditions, such as drug treatments. This new knowledge could help develop new antibiotics that work, tackling the urgent problem of antibiotic resistance. The Bacterial infections: antimicrobial therapies group led by Dr. Eduard Torrents was studying the bacterial strain Pseudomonas aeruginosa, which can cause severe chronic lung infections in cystic fibrosis (CF) patients, leading to severely impaired lung function, an increased risk of respiratory failure, and death.
Mycobacterium in olive oil for cancer treatment
Researchers at the Autonomous University of Barcelona (UAB) and Institute for Bioengineering of Catalonia (IBEC) have revealed a way to effectively deliver a mycobacterium needed for the treatment of bladder cancer in humans –using a formulation based on olive oil. The researchers have found a way to reduce the natural clumping that occurs when mycobacteria cells, which possess a high content of lipids in their walls, are introduced to the usual aqueous solutions that are used for intravesical instillation in bladder cancer patients. This clumping may interfere with the interaction of the mycobacteria-host cells and negatively influence their antitumor effects.