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by Keyword: Controlled drug release
Resina, Leonor, Caballero, Pau, Guggenbiller, Grant, Weems, Andrew C, Perez-Madrigal, Maria M, Aleman, Carlos, (2025). Multifunctional Scaffold Biosensor and Drug Delivery System for Bacterial Infection Prevention During Skin Wound Healing Macromolecular Bioscience , e00247
This study investigates a multifunctional hydrogel system integrating carboxymethyl cellulose (CMC) in a 3D-printed limonene (LIM) scaffold coated with poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS). The system allows to enhance wound healing, prevent infections, and monitor the healing progress. CMC is crosslinked with citric acid (CA) to form the hydrogel matrix (CMC-CA), while the 3D-printed limonene (LIM) scaffold is embedded within the hydrogel to provide mechanical support. PEDOT:PSS and curcumin-loaded PEDOT (PEDOT:CUR) nanoparticles are integrated into the hydrogel-membrane system for electrochemical detection of bacterial infection and controlled delivery of the antibacterial drug. The CMC-CA hydrogel exhibits excellent mechanical properties, suitable for conforming to irregular wound surfaces. In addition to provide additional mechanical support, the LIM scaffold is used as a pillar for the incorporation of PEDOT The integration of PEDOT:PSS and PEDOT:CUR enable not only real-time monitoring of bacterial growth but also the electrostimulated release of curcumin, which demonstrates antibacterial activity against Escherichia coli and Staphylococcus aureus. Electrostimulation of the CMC-CA/LIM/PEDOT system promotes cell proliferation, supporting accelerated wound healing. In conclusion, the CMC-CA/LIM/PEDOT system combines mechanical support, infection monitoring, and enhanced healing through controlled drug delivery and electrical stimulation, addressing critical challenges in wound management.
JTD Keywords: 4-ethylenedioxythiophene), Antibacterial, Behavior, Biosensor, Conducting polymer, Controlled drug release, Curcumin, Electrical-stimulation, Fields, Hydrogel, Hydrogels, In-vitro, Poly(3, Size, Tissues, Wound healing
Khurana, K., Guillem-Marti, J., Soldera, F., Mücklich, F., Canal, C., Ginebra, M. P., (2020). Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent Journal of Biomedical Materials Research - Part B Applied Biomaterials 108, (3), 760-770
Apatitic bone cements have been used as a clinical bone substitutes and drug delivery vehicles for therapeutic agents in orthopedic applications. This has led to their combination with different drugs with known ability to foster bone formation. Recent studies have evaluated Simvastatin for its role in enhanced bone regeneration, but its lipophilicity hampers incorporation and release to and from the bone graft. In this study, injectable calcium phosphate foams (i-CPF) based on α-tricalcium phosphate were loaded for the first time with Pitavastatin. The stability of the drug in different conditions relevant to this study, the effect of the drug on the i-CPFs properties, the release profile, and the in vitro biological performance with regard to mineralization and vascularization were investigated. Pitavastatin did not cause any changes in neither the micro nor the macro structure of the i-CPFs, which retained their biomimetic features. PITA-loaded i-CPFs showed a dose-dependent drug release, with early stage release kinetics clearly affected by the evolving microstructure due to the setting of cement. in vitro studies showed dose-dependent enhancement of mineralization and vascularization. Our findings contribute towards the design of controlled release with low drug dosing bone grafts: i-CPFs loaded with PITA as osteogenic and angiogenic agent.
JTD Keywords: Controlled drug release, Endothelial progenitor cells, Mineralization, Rat mesenchymal stem cells, Vascularization
