by Keyword: Stack
Gul, Merve, Quintana-Romero, Dulce A, Fontana-Escartin, Adrian, Gelmi, Maria Luisa, Perez-Madrigal, Maria M, Chiesa, Enrica, Bucci, Raffaella, Aleman, Carlos, (2025). Electrochemical Response of α/β-peptides: Influence of the Peptide Length, Stereochemistry and Self-Assembly on the Performance of Peptide-Based Electrochemical Sensors Advanced Materials Interfaces 12, e00254 
The electrochemical response of alpha/beta-peptides with (L-Ala-beta-Fpg)n sequence, where beta-Fpg refers to syn 3-amino-2-(2-fluorophenyl)-3-phenylpropanoic acid, has been investigated examining the effects of the peptide length (n = 1-3), the stereochemistry of the beta 2,3-diaryl-amino acid and their self-assembly. alpha/beta-Peptides have been deposited by drop-casting on a conducting polymer (CP) film, which is previously electropolymerized on a stainless steel conducting substrate. The current-potential response of the CP coated by the different studied peptides suggests that, for alpha/beta-peptides, the role played by the electron transport through intermolecular stacking of aromatic side groups prevails over peptide length and stereochemistry. In order to prove such a hypothesis, the experimental conditions used to achieve an ordered self-assembly are optimized for one of the alpha/beta-peptides. The achieved self-assembled structures, which consist of well-defined long microfibers, considerably improve the electrochemical response of the CP. Finally, the prepared alpha/beta-peptide-based electrodes are used to electrochemically detect the oxidation of nicotinamide adenine dinucleotide (NADH). The analytical parameters are better for electrodes with well-defined peptide microfibers than for uncoated CP, corroborating the importance of pi-pi stacking interactions in the response of alpha/beta-peptides.
JTD Keywords: Acid, Alpha/beta-peptides, Beta-peptides, Bioelectronics, Design, Electron-transfer, Foldamers, Nadh, Nadh detection, Nanomaterials, Self-assembly, Stacking interactions
Sharma, P, Venugopal, A, Verdi, CM, Roger, MS, Calò, A, Kumar, M, (2024). Heparin binding induced supramolecular chirality into the self-assembly of perylenediimide bolaamphiphile Journal Of Materials Chemistry b 12, 7292-7297
Chirality is one of the hallmarks of biomolecules. Herein, we utilize heparin, a chiral biomolecule and potent drug, to induce chiral organization into the assembly of an achiral molecule. Polyanionic heparin binds with a dicationic perylenediimide derivative to induce supramolecular helical organization in aqueous medium as well as in a highly competitive cell culture medium. Heparin, an anionic chiral biomolecule, binds to cationic achiral perylenediimide derivative to induce supramolecular helicity, forming chiral nanostructures in both aqueous and cell culture medium.
JTD Keywords: Circularly-polarized luminescence, Dichroism, Nanotubes, Polymers, Stack
