Their paper demonstrates that chemotaxis and mechanotaxis – processes in mechanical guidance – involve a delicate interplay between physical and chemical mechanisms to sense gradients, establish polarization and drive the directed migration of cells.
Reference article: Roca-Cusachs, P., Sunyer, R. & Trepat, X. (2013). “Mechanical guidance of cell migration: lessons from chemotaxis” Curr Opin Cell Biol, 25(5), 543-9