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Molecular Imaging for Precision Medicine

ABOUT

OUR FOCUS

Development and application of innovative techniques for biomarker in human diseases.

We believe that utilizing molecular imaging tools we can uncover abnormalities in cell metabolism and assess treatment efficacy.

OUR APPROACH

Combining principles from bioengineering, chemistry, and physics, we tackle biological challenges through innovative solutions. Application of Magnetic Resonance (MR) molecular imaging methods to investigate biochemical pathways and in vitro, in vivo and in innovative in bioengineered chip systems.

OUR METHODS

Hyperpolarised NMR (HP-NMR)

At the forefront of molecular imaging, our team specializes in hyperpolarized MR techniques, which amplify NMR signals over 10,000 times. This advancement allows real-time, non-invasive observation of molecular processes within a broad spectrum of biological systems, offering unprecedented insights into dynamic biological phenomena in real time. In our group we work with two HP methods: dissolution Dynamic nuclear polarization (dDDNP) and Parahydrogen Induced Polarization (PHIP).

Magnetic Resonance (MR) Imaging

Building upon the established clinical utility of MR imaging (MRI) for non-destructive tissue analysis, our work extends to MR spectroscopic imaging, which offers chemical specificity. This enables direct correlation between chemical compounds and biological events across various biological samples, including biofluids, cells, tissues, animal models, and clinical patients.

Microfluidic platforms

Microfluidic platforms, especially lab-on-a-chip devices, are revolutionizing the study of metabolism in disease by offering a compact and efficient means to analyze biological samples. These chips integrate intricate networks of microchannels and chambers, allowing for precise control and manipulation of small fluid volumes. A significant advantage of these platforms is their ability to accommodate multiple samples simultaneously for a single measurement, such as Magnetic Resonance Imaging (MRI). This unique design not only enhances throughput and reduces sample consumption but also enables high-resolution and multiplexed metabolic analysis. Consequently, microfluidic chips are becoming indispensable tools in biomedical research, providing valuable insights into disease mechanisms and facilitating the identification of metabolic biomarkers.

Metabolomics

Metabolomics is the comprehensive study of metabolites, the small molecules involved in metabolic processes within a biological system. Analysis of metabolites using NMR spectroscopy reveals insights into the biochemical activities occurring in cells, tissues, or organisms. This field is particularly useful for biomarker identification associated with particular diseases. Identifying these biomarkers can improve disease diagnosis, prognosis, and the development of personalized treatment strategies.

Computer Modelling of biological systems

By using the law of mass action, it is possible to model different cellular processes in a deterministic manner, and hence, describe these systems at a population level. These models can describe a wide range of processes, from gene expression and regulation to enzyme kinetics and particles movements thanks to membrane transporters.

STAFF

All group members:

Irene Marco Rius

Junior Group Leader
+34 9340 ext 21750
imarcoibecbarcelona.eu
Researcher profile
Alonso Reíllo, Gonzalo
Lope Piedrafita, Silvia
Mangas Florencio, Lluís
Marco Rius, Irene
Matajsz , Gergo
Miranda de Lima, Nicolle
Monreal Falconi, Irina
Ortega Machuca, Maria Alejandra
Podraza , Jakub
Ribas Serra, Vicent
Spinelli , Giovanni Vito

PROJECTS

INTERNATIONAL PROJETCSFINANCERPI
BLOC · Benchtop NMR for Lab-on-Chip (2020 – 2022)European Commission, FET OPENIrene Marco
NATIONAL PROJECTSFINANCERPI
Analisis metabolico en tiempo real de modelos de cultivo de celulas 3d de la enfermedad del higado graso no alcoholico: organos en un chip y resonancia magnetica nuclear (2020 – 2021)MINECO, Acciones Dinamización Europa Investigación/EIN2020-112209Irene Marco
Junior Leader Programe (2018 – 2022)Obra Social La Caixa, Junior Leader ProgramIrene Marco
 

PUBLICATIONS

For a list of publications prior to joining IBEC, visit the Google Scholar.

Check for more detailed information on the outputs of the Group at IBEC CRIS portal.

Publications list:

NEWS

The group led by Irene Marco-Rius at IBEC is part of GLIOLIFE-AECC, a project funded with €10 million by the Spanish Association Against Cancer (AECC) and its Scientific Foundation to increase survival in people with glioblastoma, the most common and aggressive brain tumour in adults. The IBEC team will lead the consortium’s innovative radiology line, which will use an advanced imaging technique to study the tumour’s metabolism without the need for invasive procedures.

IBEC to take part in GLIOLIFE-AECC, the largest research consortium against glioblastoma

The group led by Irene Marco-Rius at IBEC is part of GLIOLIFE-AECC, a project funded with €10 million by the Spanish Association Against Cancer (AECC) and its Scientific Foundation to increase survival in people with glioblastoma, the most common and aggressive brain tumour in adults. The IBEC team will lead the consortium’s innovative radiology line, which will use an advanced imaging technique to study the tumour’s metabolism without the need for invasive procedures.

IBEC researchers joined the activities of European Researchers’ Night 2026, held at CosmoCaixa and the Gabriel García Márquez Library last week. With activities on magnets, bacteria, nanoparticles and light, the aim was to showcase excellent research, spark interest in science and show how scientific work has an impact on people’s everyday lives.

IBEC takes part in European Researchers’ Night once again, reaching around 290 people

IBEC researchers joined the activities of European Researchers’ Night 2026, held at CosmoCaixa and the Gabriel García Márquez Library last week. With activities on magnets, bacteria, nanoparticles and light, the aim was to showcase excellent research, spark interest in science and show how scientific work has an impact on people’s everyday lives.

The Institute for Bioengineering of Catalonia (IBEC) has installed a new POLARIS system in Barcelona, one of the first two quantum-enhanced MRI systems deployed under the EU-funded Q-AID project, alongside a twin installation at the University of Antwerp. The system marks IBEC’s entry into a four-year, €8.3 million European initiative to build a shared platform for quantum-enhanced metabolic imaging.

IBEC installs first POLARIS system, launching Barcelona’s role in the European Q-AID quantum-MRI network

The Institute for Bioengineering of Catalonia (IBEC) has installed a new POLARIS system in Barcelona, one of the first two quantum-enhanced MRI systems deployed under the EU-funded Q-AID project, alongside a twin installation at the University of Antwerp. The system marks IBEC’s entry into a four-year, €8.3 million European initiative to build a shared platform for quantum-enhanced metabolic imaging.

The BIST Forum 2026 brought together scientists and representatives from academic, economic and social institutions to discuss how frontier research can help build Europe’s industries of the future. The event also announced the recipients of the BIST To the Mothers of Science and Ignite programmes.

BIST calls for reforms to turn scientific discoveries into European industry

The BIST Forum 2026 brought together scientists and representatives from academic, economic and social institutions to discuss how frontier research can help build Europe’s industries of the future. The event also announced the recipients of the BIST To the Mothers of Science and Ignite programmes.

In a significant advancement for lab-on-chip technology, IBEC researchers in the frame of the European project BLOC, have demonstrated the first integration of a benchtop nuclear magnetic resonance (NMR) spectrometer … Read more

Landmark in Real-Time Metabolic Monitoring on Chip: BLOC Benchtop NMR comes to light

In a significant advancement for lab-on-chip technology, IBEC researchers in the frame of the European project BLOC, have demonstrated the first integration of a benchtop nuclear magnetic resonance (NMR) spectrometer … Read more

IBEC researcher Amayra Hernández-Vega has been awarded a grant from the Pasqual Maragall Researchers Programme to lead a project focused on studying the earliest stages of Alzheimer’s disease. The study will combine in vitro and human models of familial Alzheimer’s disease to identify age-related factors and potential inhibitors that could slow the early progression of the disease. The project was presented at an informative session on sleep and brain health, which was attended by around 500 people.

Amayra Hernández-Vega receives a grant from the Pasqual Maragall Foundation to advance research on the early stages of Alzheimer’s

IBEC researcher Amayra Hernández-Vega has been awarded a grant from the Pasqual Maragall Researchers Programme to lead a project focused on studying the earliest stages of Alzheimer’s disease. The study will combine in vitro and human models of familial Alzheimer’s disease to identify age-related factors and potential inhibitors that could slow the early progression of the disease. The project was presented at an informative session on sleep and brain health, which was attended by around 500 people.

Dr Benedetta Bolognesi, Dr Irene Marco-Rius and Dr Nicolò Accanto, who are all principal investigators at IBEC, have each been awarded a prestigious ERC Proof of Concept grant. These grants are awarded by the European Research Council to support the exploration of the commercial and societal potential of research projects conducted within European institutions. The three winning projects range from new platforms for discovering antiamyloid drugs, to advanced metabolic analysis technologies, to optical tools for studying the brains of animals moving naturally.

Three IBEC projects receive ERC Proof of Concept funding to drive innovation in health, neuroscience, and biomedical technology 

Dr Benedetta Bolognesi, Dr Irene Marco-Rius and Dr Nicolò Accanto, who are all principal investigators at IBEC, have each been awarded a prestigious ERC Proof of Concept grant. These grants are awarded by the European Research Council to support the exploration of the commercial and societal potential of research projects conducted within European institutions. The three winning projects range from new platforms for discovering antiamyloid drugs, to advanced metabolic analysis technologies, to optical tools for studying the brains of animals moving naturally.

Irene Marco fue becada por la Fundación ”la Caixa” en dos ocasiones. La primera, para cursar un máster en Biofísica en la Universidad de Heidelberg (Alemania). La segunda, para desarrollar su investigación posdoctoral en Biología Molecular y Bioquímica en el IBEC. Esta es su historia contada a la periodista y escritora Llucia Ramis.

Fundación “la Caixa”: Diálogos entre Irene Marco y Llucia Ramis

Irene Marco fue becada por la Fundación ”la Caixa” en dos ocasiones. La primera, para cursar un máster en Biofísica en la Universidad de Heidelberg (Alemania). La segunda, para desarrollar su investigación posdoctoral en Biología Molecular y Bioquímica en el IBEC. Esta es su historia contada a la periodista y escritora Llucia Ramis.

Barcelona hosted the third IBEC-WCH Precision Medicine Conference this week, an event that further strengthened the strategic alliance between the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital of Sichuan University (WCHSU). The Chinese delegation visited Spain from 26 to 29 November, taking part in a busy schedule of scientific and institutional activities and exchanges between the two centres.

The IBEC and West China Hospital hold their third joint conference on precision medicine in Barcelona

Barcelona hosted the third IBEC-WCH Precision Medicine Conference this week, an event that further strengthened the strategic alliance between the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital of Sichuan University (WCHSU). The Chinese delegation visited Spain from 26 to 29 November, taking part in a busy schedule of scientific and institutional activities and exchanges between the two centres.

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