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Under pressure: when tension builds up, the nucleus escapes

Researchers at IBEC have discovered that epithelial tissues adapt to prolonged stretching by slowly reorganising their keratin cytoskeleton into large multicellular networks. Using advanced live imaging, engineered tissue models and computational simulations, the team found that this process eventually pushes the cell nucleus out of its surrounding keratin cage. The findings reveal a previously unknown mechanism by which tissues respond to sustained mechanical stress, with potential implications for development, organ physiology and diseases linked to defective keratin organisation.

PHYS.ORG: Prolonged stretching reorganizes tissue scaffolds and uncages cell nuclei

How do tissues cope with being stretched for hours or even days? A study led by researchers at the Institute for Bioengineering of Catalonia (IBEC) has uncovered an unexpected answer: Cells radically reorganize their internal scaffolding and, in the process, release their nuclei from a protective keratin network.

3Cat | TELENOTÍCIES MIGDIA: Ratolins cecs recuperen la visió amb un nou fàrmac

El Instituto de Biotecnología de Cataluña lidera una investigación que ha desarrollado un fármaco en forma de colirio que permite recuperar la visión en ratones ciegos, con ensayos clínicos previstos en humanos en cuatro años. Declaraciones de Rosalba Sortino, autora del estudio Instituto de bioingeniería de Cataluña.; Joaquín Martínez Tambella, coautor del estudio Instituto de Biotecnología de Cataluña.