New study reveals how protein behaviour drives blood–brain barrier specialization
The research, led by the Institute for Bioengineering of Catalonia, reveals that the blood–brain barrier is defined not only by the proteins it expresses, but by how it uses them, through a dynamic property known as endocytic turnover rate (ETOR). This discovery shows that brain endothelial cells have a unique molecular behaviour that distinguishes them from other blood vessels and can be disrupted during inflammation. The results provide new insight into how the barrier functions and fails in disease which may help identify novel therapeutic strategies to restore neurovascular health.