Moldless approach to generate 3D intestinal tissue model using hydrogels

The Biomimetic systems for cell engineering group has developed a new method to generate 3D intestinal tissue using hydrogels. This new in vitro model has been improved by providing cells with a more physiologically realistic environment, including tissue architecture, cell-matrix interactions and chemical signalling while remaining compatible with standard cell characterization techniques.

Epithelial tissues contain complex three-dimensional microtopographies that are essential for their proper performance. These 3D microstructures provide cells with the physicochemical and mechanical signals needed to guide their self-organization into functional tissue structures and are key to their proper functioning.