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Genetic mutations

An unprecedented mutation map reveals how amylin mutations influence type 2 diabetes

A study by the Institute for Bioengineering of Catalonia (IBEC) has created a mutational map of the hormone amylin, the aggregation of which can damage pancreatic cells and lead to type 2 diabetes. The team analysed 1,916 variants of the protein and compared the results of this mutational map with genetic and clinical data from 500,000 individuals. The study, published in Nature Communications, sheds new light on the role of genetics in diabetes and could lead to the development of safer and more effective drugs.

IBEC co-organised the leading international symposium on mutational scanning

Family foto of the 8th Mutational Scanning Symposium at the Barcelona Biomedical Research Park (PRBB).

More than 300 people attended the eighth Mutational Scanning Symposium, which took place from 21 to 23 May at the Barcelona Biomedical Research Park. The symposium is a key event for discussing the latest advances in mutational scanning technologies and Multiplex Assays of Variant Effects. This year, the symposium was co-organised by the Institute for Bioengineering of Catalonia, the Centre for Genomic Regulation, and the international Atlas of Variant Effects initiative.