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IBEC researchers uncover strategy to reduce chemotherapy side effects

Researchers at IBEC and IDIBELL have developed a light-regulated molecule that could improve chemotherapy treatments by controlling the activity of anticancer agents.

Chemotherapy – the use of cytotoxic agents to kill the rapidly proliferating cells in tumors – is one of our main tools in the fight against cancer. However, its effectiveness and the body’s tolerance of it is often dramatically limited: it can affect healthy areas rather than just the cancerous ones, which causes side effects.

Molecules activated by light to control glutamate receptors

immunoliposomes Researchers at IBEC, IQAC-CSIC and CNRS have developed molecules that can modulate the activity of glutamate receptors in the central nervous system, with important applications in biomedicine.

For the last few years the collaborators have been working on the development of molecules called targeted covalent photoswitches (TCPs), whose structure can be changed using light. This change in shape causes the molecule to be recognized – or not – by a biological receptor as a key is to a lock. This coupling activates the receptor or not, triggering the activity.

Celebrating advances in spinal cord and brain research by Marató-funded projects

pgorostiza_allobet_IBEC group leader and ICREA research professor Pau Gorostiza took part in the 17th Symposium of La Marató de TV3 this week, which was devoted to the celebration of the 30 research projects awarded funding by the telethon in 2010.

The event at the Institut d’Estudis Catalans on Wednesday, which included a poster session open to the public, featured round tables of experts discussing the findings of the projects, which covered research into the understanding, treatment and prognosis acquired spinal cord and brain injuries.