Biomaterials for regenerative therapies


Elisabeth Engel López | Group Leader
Oscar Castaño Linares | Senior Researcher
Miguel Angel Mateos Timoneda | Senior Researcher
Soledad Pérez Amodio | Senior Researcher
Irene Cano Torres | PhD Student
Joan Martí Muñoz | PhD Student
Jesús Ordoño Fernández | PhD Student
Gerard Rubí Sans | PhD Student
Alessandra Soriente | PhD Student
Andrea Martin Vazquez | Masters Student
Alejandro Martínez Codes | Masters Student
Manon Sleddens | Masters Student
Robin Zagala | Masters Student

Former Member

Prof. Josep Planell | Director, Universitat Oberta de Catalunya (UOC)

About

Research in the Biomaterials for Regenerative Therapies group is devoted to the development and knowledge transfer to industry of innovative biomaterials and scaffolds for tissue regeneration.

PLA nanofibers coated with Silicon nanoparticles (Joan Martí)

We design, fabricate and characterize bioactive and biodegradable materials and investigate their interactions with biological entities, both in terms of their fundamental aspects and with specific applications for tissue engineering purposes in mind. The aim is the repair and functional restoration of tissues or organs by means of 3D scaffolds, cells and signals.

Different research areas are being developed in the group:

The production of polymeric biomaterials using different fabrication techniques: by using a polymer nanoprecipitation technique, the group produced nanoparticles for antibiotic drug delivery that effectively treated persistent bacterial infections. The use of a jet break-up polymer precipitation technique together with protein/peptide functionalization allowed the group to produce micro particles for effective cell delivery.

Human Mesenchymal Stem cells forming networks within a functionalized Polyethylene Glycol Hydrogel containing calcium-phosphate particles. (Claudia Navarro)

The production of structured bioactive nanocomposites that can enhance vascularization, bone and skin regeneration, either by electrospinning, rapid prototyping or micro-particles production. In 2016 we were awarded by a CAIXAIMPULSE first edition project to bring our “Dermoglass” project to a closer commercialization stage. Thus, within the IBEC-LaCaixa Joint program we are developing new nanoparticles that have an antimicrobial effect to add this property to the dressing. This project also obtained an award by EIT Health to enhance IP protection and scalability for further commercialization.

Recent advances describe a novel hybrid material which faithfully mimics the structure of bone’s extracellular matrix, recreating the molecular architecture and biochemical environment to surround cells with the proper stimuli to spread and grow (Sachot N et al., 2016, J Mater Chem B). Other biomaterials developed in the group such as hybrid fibrous mats with different contents of calcium-releasing nanoparticles are able to induce angiogenesis in in vivo models (Oliveira H. et al., 2016, Acta Biomaterialia).

Microtiusses formed with rMSC cells on polylactic acid microparticle scaffolds. (Irene Cano)

In collaboration with the group of Prof. Rodriguez-Cabello from the University of Valladolid, the group developed microstructured biomimetic hydrogels using new crosslink methods that induce bone formation in vivo. These biomaterials have also been combined with 3D printed hydroxyapatite scaffolds to enhance bone formation in collaboration with Prof. Vallet and Prof. Bujan (Vila et al. Acta Biomaterialia 2016).

In collaboration with Prof. del Rio and Prof. Trepat at IBEC and Prof. Kevin Healy at Berkeley, fabrication of customized biomaterials and/or microfluidics based platforms for the fundamental study of biological systems related to angiogenesis processes and neural regeneration have been developed. We have used signalling gradients of concentration to address progenitor cells to the desired target.

Cardiac fibroblasts integrate within the PLA fibers ECM-like matrix (Jesús Ordoño)

A new project awarded by MINECO has started. We have been working on microparticles to produce new bioinks to print organs such as bone and produce microtissues as systems to model pathologies like cancer. This microtissues can be created inside a bioreactor and use this bioreactor to decellullarize and recellularize with the appropriate cells and can be controlled by means of bioluminescence.

Finally, we have started a project to develop instructive matrices to activate cardiac cells to promote cardiac regeneration.

News/Jobs

3D printing biocompatible hydrogels
08/03/17

IBEC researchers have laid the groundwork for faster advances in 3D bioprinting for regenerative medicine by creating a system of ink and matrices that offers a solid basis for tissue regeneration.


IBEC at the Mobile World Congress
01/03/17

This week IBEC is taking part in the Youth Mobile Festival (YOMO) of the Mobile World Congress, the world’s largest gathering for the mobile industry, with an interactive stand about bioengineering for cardiac regeneration.


IBEC researchers win EIT Health awards
19/12/16

IBEC group leaders Eduard Torrents and Elisabeth Engel both received awards at last week’s EIT Health Spain event at the PCB.


Strengthening links with Singapore
30/09/16

This week IBEC director Josep Samitier, group leaders Elisabeth Engel, Xavier Trepat and Pere Roca-Cusachs, and Ester Sánchez, representing the Strategic Initiatives Unit, are in Singapore to take part in the first IBEC-MBI Joint Symposium, which took place on 26th September.


BIYSC: helping students unlock their potential
13/07/16

This month IBEC is taking part in the Barcelona International Youth Science Challenge (BIYSC 2016), a new initiative that aims to stimulate scientific talent among young people from all over the world.


IBEC group presents 4th generation biomaterial that mimics bone
03/09/15

IBEC researchers have published a paper in Nanoscale elucidating a brand new biomaterial that paves the way towards a fourth generation of effective structures for tissue regeneration.


IBEC groups join forces to combat chronic bacterial infections
28/04/15

A study published today in the Journal of Controlled Release describes a new nanoparticle strategy able to target hard-to tackle infections caused by biofilm-forming bacteria.


CIBER-BBN YSF in Biomaterials Award goes to IBEC researcher
14/11/14

Oscar Castaño, a senior researcher in IBEC’s Biomaterials for Regenerative Therapies group, has been awarded the CIBER-BBN YSF in Biomaterials prize for 2012-2014.


Televisió L’H: L’Informatiu 13-11-2014
14/11/14

Miguel Angel Mateos from the Biomaterials for Regenerative Therapies group was interviewed for Televisió L’Hospitalet after his participation in this year’s Setmana de la Ciència, for which he gave a talk entitled “Regeneració de teixits : com nou” at the Centre Cultural Sant Josep on Wednesday.


“Inversió de Futur”
8/10/14

Josep A. Planell, rector of the UOC and Research Fellow at IBEC, appears in a new documentary about technology transfer in Catalonia, Inversió de Futur.


“Implants per autoregenerar el cervell”
30/06/14

The Biomaterials for Regenerative Therapies group has appeared on science programme ‘El problema de Gettier’. Junior group leader Elisabeth Engel talks about the group’s development of a tuned implant that could aid the regeneration of brain tissue, particularly in cases of pre- and postnatal injury.


Position for a PhD candidate to apply for the next 2014 FI call
25/08/14

Now closed


IBEC winner to give address at RecerCaixa ceremony
26/03/14

At Friday 28th March’s official ceremony for the 2013 round of RecerCaixa funding, IBEC junior group leader Elisabeth Engel will represent all the winners and centres as the investigator chosen to speak at the event.


Helping the brain rebuild itself
25/03/14

Tissue regeneration researchers at IBEC, UB and the UPC have developed an implant that could aid the regeneration of brain tissue, particularly in cases of pre- and postnatal injury.


RecerCaixa funding for IBEC projects
29.01.14

Awards will support researchers’ work on a system to aid rehabilitation in children, and improved healing in shoulder injuries.


Position for a PhD candidate to apply for the next 2013 FPU call of the Ministerio
27/11/2013

Now closed


Media coverage of Dermoglass
10/2013 to 12/2013

Follow the media coverage of the Dermoglass crowdfunding project in the IBEC in the Media section of the web.


IBEC crowdfunding project now accepting donations!
14/10/2013

IBEC’s very first venture into crowdfunding, which has come about as an initiative of the Biomaterials for Regenerative Therapies group, goes live today on the crowdfunding website www.goteo.org.


Josep A. Planell first Spanish scientist to receive European biomaterials prize
12/09/2013

Josep A. Planell, founding director of IBEC, was presented with the European Society of Biomaterials’ prestigious George Winter prize at their annual conference held in Madrid on Tuesday.


Engineering biomaterials at the nanoscale
28/08/2013

IBEC researchers have come up with a groundbreaking new approach to create a tough, biodegradable, bioactive and entirely new material, heralding a major milestone in the production of artificial matrices for tissue engineering. In a letter published today in the Royal Society journal Interface, the Biomaterials for Regenerative Therapies group describes a new, easy and cheap method for producing glass-coated fibrous scaffolds which not only faithfully mimic the extracellular matrix of bone, but also aim to direct stem cell fate through physical and chemical interactions.


A step towards repairing the central nervous system
22/01/2013

Researchers from IBEC and the University of Barcelona have revealed a promising new strategy for regenerating the central nervous system, in a paper published in the journal Biomaterials.


Smart biomaterial promotes angiogenesis
25/07/2012

IBEC researchers have stuck tissue engineering gold with the creation of a new ‘smart’ biomaterial that triggers angiogenesis by providing the biochemical and mechanical cues needed for the process to begin.


Developing a new solution to treat atherosclerosis
27/02/2012

We’ve all eaten rich meals or fatty foods and joked that we can feel our ‘arteries hardening’. However, the reality of atherosclerosis – when fat, cholesterol, and other substances build up in the artery walls and form solid structures called plaques – is no joking matter. The consequences of this disorder can include stroke and coronary artery disease, the leading cause of death in many developed countries.


Green light for regeneration projects
08/02/2012

The two IBEC-led CIBER-BBN tissue regeneration projects that were earmarked for funding by the EU’s ERA-NET EuroNanoMed initiative last year (see www.ibecbarcelona.eu/IBEC-News/funding-success-for-two-ibec-projects.html) have both received the national support they need to get started.


New year, new name
5/01/2012

IBEC director Josep Planell’s research group has changed its name and is now known as the Biomaterials for Regenerative Therapies group.


IBEC director elected to the Royal Academy of Science and Arts of Barcelona
17/12/2010

In the beautiful surroundings of Academy House on Rambla dels Estudis last night, IBEC director Josep Planell was elected as Academician of the Royal Academy of Science and Arts of Barcelona (RACAB).


‘Biowaffle’ wins Image of the Year 2010
16/12/2010

The lucky winners of the Image of the Year 2010 competition received their prizes today.


The regeneration game
03/12/2010

Tackling tissue morphogenesis in humans


www.noticiascadadia.com: “Oportunidades de crecimiento de los biomateriales en las tecnologías médicas”
20/10/2010

An announcement on www.noticiascadadia.com about 20 October’s Biocat-organised meeting on ‘Biomateriales: de la biónica hacia la regeneración y las terapias avanzadas’ at the Museo Colet in Barcelona.


The Guardian Supplement: Nanotechnology 2009 – Part 1
27/08/2009

Josep Planell, Director of the Institute for Bioengineering of Catalonia, explains his work on tissue regeneration at the nanoscale.


Entrevista a Josep A. Planell al diari El Mundo
16/09/2007

El passat 16 de setembre, el diari El Mundo, dins el seu suplement de Biotecnologia, va publicar una entrevista a Josep A. Planell, director de l’IBEC.

Projects

EU-funded projects
THE GRAIL Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer (2012-2016) HEALTH Elisabeth Engel
Materiales angiogénicos nanoestructurados para fracturas óseas no consolidadas EURONANOMED Elisabeth Engel
Privately funded projects
BIOTENDON Tendon Tissue Engineering: A Helping Hand for Rotator Cuff Tears RECERCAIXA Elisabeth Engel
DERMOGLASS Smart dressing for the treatment of chronic wounds (2016-2017) Obra Social La Caixa, Caixaimpulse Xavier Puñet
National projects
Diseño y desarrollo de Biomateriales bioactivos para la regeneración de la piel basada en la señalización controlada de liberación de iones (2013-2016)
I+D-Investigación fundamental no orientada Elisabeth Engel
Andamios diseñados para promover una vascularización eficiente para fracturas óseas no consolidadas (2012-2016)
I+D-Investigación fundamental no orientada Oscar Castaño
INSBIOMAT Biomateriales instructivos para regeneración cardíaca in vivo (2015-2016) MINECO, Acciones Dinamización “Europa Excelencia” Elisabeth Engel
MatriCell Desarrollo de partículas poliméricas para generar matrices extracelulares in vitro (2016-2018) MINECO, Retos investigación: Proyectos I+D Elisabeth Engel

Publications

Punet, X., Levato, R., Bataille, I., Letourneur, D., Engel, E., Mateos-Timoneda, M. A., (2017). Polylactic acid organogel as versatile scaffolding technique Polymer 113, 81-91

Echalier, C., Levato, R., Mateos-Timoneda, M. A., Castaño, O., Déjean, S., Garric, X., Pinese, C., Noël, D., Engel, E., Martinez, J., Mehdi, A., Subra, G., (2017). Modular bioink for 3D printing of biocompatible hydrogels: sol-gel polymerization of hybrid peptides and polymers RSC Advances 7, 20, 12231-12235

Guduric, V., Metz, C., Siadous, R., Bareille, R., Levato, R., Engel, E., Fricain, J. C., Devillard, R., Luzanin, O., Catros, S., (2017). Layer-by-layer bioassembly of cellularized polylactic acid porous membranes for bone tissue engineering Journal of Materials Science: Materials in Medicine 28, 5, 78

Álvarez, Zaida, Hyroššová, Petra, Perales, José Carlos, Alcántara, Soledad, (2016). Neuronal progenitor maintenance requires lactate metabolism and PEPCK-M-directed cataplerosis Cerebral Cortex 26, 3, 1046-1058

Vila, M., García, A., Girotti, A., Alonso, M., Rodríguez-Cabello, J. C., González-Vázquez, A., Planell, J. A., Engel, E., Buján, J., Garcíaa-Honduvilla, N., Vallet-Regí, M., (2016). 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine Acta Biomaterialia 45, 349-356

Oliveira, Hugo, Catros, Sylvain, Boiziau, Claudine, Siadous, Robin, Marti-Munoz, Joan, Bareille, Reine, Rey, Sylvie, Castano, Oscar, Planell, Josep, Amédée, Joëlle, Engel, Elisabeth, (2016). The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment Acta Biomaterialia 29, 435-445

Sachot, N., Castaño, O., Oliveira, H., Martí-Muñoz, J., Roguska, A., Amedee, J., Lewandowska, M., Planell, J. A., Engel, E., (2016). A novel hybrid nanofibrous strategy to target progenitor cells for cost-effective: In situ angiogenesis Journal of Materials Chemistry B 4, 43, 6967-6978

Vila, O. F., Garrido, C., Cano, I., Guerra-Rebollo, M., Navarro, M., Meca-Cortés, O., Ma, S. P., Engel, E., Rubio, N., Blanco, J., (2016). Real-time bioluminescence imaging of cell distribution, growth, and differentiation in a three-dimensional scaffold under interstitial perfusion for tissue engineering Tissue Engineering Part C: Methods 22, 9, 864-872

Torrents, E., Baelo, Aida, Levato, R., Julián, E., Crespo, Anna, Astola, Josep, Gavaldà, J., Engel, E., Mateos-Timoneda, M.A., (2016). Mejora en la administración antibiotic para el tratamiento de infecciones en forma de biofilm con el uso de nanopartículas que disgregan la matriz extracellular Enfermedades Infecciosas y Microbiología Clínica Elsevier 34, SE1, 31

Sánchez-Ferrero, Aitor, Mata, Álvaro, Mateos-Timoneda, Miguel A., Rodríguez-Cabello, José C., Alonso, Matilde, Planell, Josep, Engel, Elisabeth, (2015). Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration Biomaterials 68, 42-53

Sachot, N., Mateos-Timoneda, M. A., Planell, J. A., Velders, A. H., Lewandowska, M., Engel, E., Castaño, O., (2015). Towards 4th generation biomaterials: A covalent hybrid polymer-ormoglass architecture Nanoscale 7, 37, 15349-15361

Baelo, Aida, Levato, Riccardo, Julián, Esther, Crespo, Anna, Astola, José, Gavaldà, Joan, Engel, Elisabeth, Mateos-Timoneda, Miguel Angel, Torrents, Eduard, (2015). Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections Journal of Controlled Release 209, 150-158 [Open Access]

Kovtun, A., Goeckelmann, M. J., Niclas, A. A., Montufar, E. B., Ginebra, M. P., Planell, J. A., Santin, M., Ignatius, A., (2015). In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams Acta Biomaterialia Elsevier Ltd 12, 1, 242-249

Levato, R., Planell, J. A., Mateos-Timoneda, M. A., Engel, E., (2015). Role of ECM/peptide coatings on SDF-1 Acta Biomaterialia 18, 59-67 [Open Access]

Sachot, Nadège, Castano, Oscar, Planell, Josep A., Engel, Elisabeth, (2015). Optimization of blend parameters for the fabrication of polycaprolactone-silicon based ormoglass nanofibers by electrospinning Journal of Biomedical Materials Research - Part B: Applied Biomaterials 103, 6, 1287–1293

Won, J. E., Mateos-Timoneda, M. A., Castaño, O., Planell, J. A., Seo, S. J., Lee, E. J., Han, C. M., Kim, H. W., (2015). Fibronectin immobilization on to robotic-dispensed nanobioactive glass/polycaprolactone scaffolds for bone tissue engineering Biotechnology Letters 37, 4, 935-342

Engel, E., Planell, J. A., Castaño, O., Navarro, M., (2014). Glass nanoparticles Universitat Politècnica de Catalunya; Fundació Institut de Bioenginyeria de Catalunya , PCT/IB2014/000522,

Álvarez, Z., Castaño, O., Castells, A. A., Mateos-Timoneda, M. A., Planell, J. A., Engel, E., Alcántara, S., (2014). Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold Biomaterials 35, 17, 4769-4781

Castaño, O., Sachot, N., Xuriguera, E., Engel, E., Planell, J. A., Park, J. H., Jin, G. Z., Kim, T. H., Kim, J. H., Kim, H. W., (2014). Angiogenesis in bone regeneration: Tailored calcium release in hybrid fibrous scaffolds ACS Applied Materials and Interfaces 6, 10, 7512-7522

Tejeda-Montes, E., Smith, K. H., Rebollo, E., Gómez, R., Alonso, M., Rodriguez-Cabello, J. C., Engel, E., Mata, Alvaro., (2014). Bioactive membranes for bone regeneration applications: Effect of physical and biomolecular signals on mesenchymal stem cell behavior Acta Biomaterialia 10, 1, 134-141

Vila, O. F., Martino, M. M., Nebuloni, L., Kuhn, G., Pérez-Amodio, S., Müller, R., Hubbell, J. A., Rubio, N., Blanco, J., (2014). Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors Acta Biomaterialia 10, 10, 4377-4389

González-Vázquez, A., Planell, J. A., Engel, E., (2014). Extracellular calcium and CaSR drive osteoinduction in mesenchymal stromal cells Acta Biomaterialia 10, 6, 2824–2833

Almeida, C. R., Serra, T., Oliveira, M. I., Planell, J. A., Barbosa, M. A., Navarro, M., (2014). Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: Unraveling the effect of 3-D structures on inflammation Acta Biomaterialia 10, 2, 613-622

Arcos, D., Boccaccini, A. R., Bohner, M., Díez-Pérez, A., Epple, M., Gómez-Barrena, E., Herrera, A., Planell, J. A., Rodríguez-Mañas, L., Vallet-Regí, M., (2014). The relevance of biomaterials to the prevention and treatment of osteoporosis Acta Biomaterialia 10, 5, 1793-1805

Levato, R., Visser, J., Planell, J. A., Engel, E., Malda, J., Mateos-Timoneda, M. A., (2014). Biofabrication of tissue constructs by 3D bioprinting of cell-laden microcarriers Biofabrication 6, 3, 035020 (12)

Salvagni, E., Berguig, G., Engel, E., Rodriguez-Cabello, J. C., Coullerez, G., Textor, M., Planell, J. A., Gil, F. J., Aparicio, C., (2014). A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces Colloids and Surfaces B: Biointerfaces 114, 225-233

Sanzana, E. S., Navarro, M., Ginebra, M. P., Planell, J. A., Ojeda, A. C., Montecinos, H. A., (2014). Role of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds Journal of Biomedical Materials Research - Part A 102, 6, 1767-1773

Rajzer, I., Menaszek, E., Kwiatkowski, R., Planell, J. A., Castaño, O., (2014). Electrospun gelatin/poly( Materials Science and Engineering: C 44, 183-190

Serra, T., Ortiz-Hernandez, M., Engel, E., Planell, J. A., Navarro, M., (2014). Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds Materials Science and Engineering: C 38, 1, 55-62

Dessì, M., Alvarez-Perez, M. A., De Santis, R., Ginebra, M. P., Planell, J. A., Ambrosio, L., (2014). Bioactivation of calcium deficient hydroxyapatite with foamed gelatin gel. A new injectable self-setting bone analogue Journal of Materials Science: Materials in Medicine 25, 2, 283-295

Mateos-Timoneda, M. A., Castaño, O., Planell, J. A., Engel, E., (2014). Effect of structure, topography and chemistry on fibroblast adhesion and morphology Journal of Materials Science: Materials in Medicine 25, 7, 1781-1787

Sachot, N., Engel, E., Castaño, O., (2014). Hybrid organic-inorganic scaffolding biomaterials for regenerative therapies Current Organic Chemistry 18, 18, 2299-2314

Álvarez, Z., Sena, E., Mattotti, M., Engel, E., Alcántara, S., (2014). An efficient and reproducible method to culture Bergmann and cortical radial glia using textured PMMA Journal of Neuroscience Methods 232, 93-101

Pérez-Amodio, Soledad, Engel, Elisabeth, (2014). Bone biology and Regeneration John Wiley & Sons, Ltd , 315-342

Castaño, Oscar, Planell, Josep A., (2014). Cements John Wiley & Sons, Ltd , 193-247

Mendes, A. C., Smith, K. H., Tejeda-Montes, E., Engel, E., Reis, R. L., Azevedo, H. S., Mata, Alvaro, (2013). Co-assembled and microfabricated bioactive membranes Advanced Functional Materials 23, 4, 430-438

Álvarez, Zaida, Mateos-Timoneda, Miguel A., Hyrossová, Petra, Castaño, Oscar, Planell, Josep A., Perales, José C., Engel, Elisabeth, Alcántara, Soledad, (2013). The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche Biomaterials 34, 9, 2221-2233

Punet, X., Mauchauffé, R., Giannotti, M. I., Rodríguez-Cabello, J. C., Sanz, F., Engel, E., Mateos-Timoneda, M. A., Planell, J. A., (2013). Enhanced cell-material interactions through the biofunctionalization of polymeric surfaces with engineered peptides Biomacromolecules 14, 8, 2690-2702

Serra, T., Planell, J. A., Navarro, M., (2013). High-resolution PLA-based composite scaffolds via 3-D printing technology Acta Biomaterialia 9, 3, 5521-5530

Montufar, E. B., Maazouz, Y., Ginebra, M. P., (2013). Relevance of the setting reaction to the injectability of tricalcium phosphate pastes Acta Biomaterialia 9, 4, 6188-6198

Gustavsson, J., Planell, J., Engel, E., (2013). Ion-selective electrodes to monitor osteoblast-like cellular influence on the extracellular concentration of calcium Journal of Tissue Engineering and Regenerative Medicine 7, 8, 609-620

Sachot, N., Castaño, Oscar, Mateos-Timoneda, Miguel A., Engel, Elisabeth, Planell, Josep A., (2013). Hierarchically engineered fibrous scaffolds for bone regeneration Journal of The Royal Society Interface 10, 88, 20130684

López-Bosque, M. J., Tejeda-Montes, E., Cazorla, M., Linacero, J., Atienza, Y., Smith, K. H., Lladó, A., Colombelli, J., Engel, E., Mata, Alvaro, (2013). Fabrication of hierarchical micro-nanotopographies for cell attachment studies Nanotechnology 24, 25, 255305

Vila, Olaia F., Bagó, Juli R., Navarro, Melba, Alieva, Maria, Aguilar, Elisabeth, Engel, Elisabeth, Planell, Josep, Rubio, Nuria, Blanco, Jerónimo, (2013). Calcium phosphate glass improves angiogenesis capacity of poly(lactic acid) scaffolds and stimulates differentiation of adipose tissue-derived mesenchymal stromal cells to the endothelial lineage Journal of Biomedical Materials Research - Part A 101A, 4, 932-941

Salerno, A., Levato, R., Mateos-Timoneda, M. A., Engel, E., Netti, P. A., Planell, J. A., (2013). Modular polylactic acid microparticle-based scaffolds prepared via microfluidic emulsion/solvent displacement process: Fabrication, characterization, and in vitro mesenchymal stem cells interaction study Journal of Biomedical Materials Research - Part A 101A, 3, 720-732

Serra, T., Mateos-Timoneda, M. A., Planell, J., Navarro, M., (2013). 3D printed PLA-based scaffolds: A versatile tool in regenerative medicine Organogenesis 9, 4, 239-244

Best, S., Planell, J. A., Santin, M., Voskerician, G., Amédée, J., (2013). Editorial Journal of Materials Science: Materials in Medicine 24, 6, 1333-1334

Bianconi, E., Piovesan, A., Facchin, F., Beraudi, A., Casadei, R., Frabetti, F., Vitale, L., Pelleri, M. C., Tassani, S., Piva, F., Perez-Amodio, S., Strippoli, P., Canaider, S., (2013). An estimation of the number of cells in the human body Annals of Human Biology 40, 6, 463-471

Pandit, A., Planell, J.A., Navarro, M., (2013). Titanium and Nitinol (NiTi) Academic Press Classes of Materials Used in Medicine, 120-124

Shin, Song-Hee, Purevdorj, Odnoo, Castano, Oscar, Planell, Josep A., Kim, Hae-Won, (2012). A short review: Recent advances in electrospinning for bone tissue regeneration Journal of Tissue Engineering 3, 1, 2041731412443530

Ginebra, M. P., Canal, C., Espanol, M., Pastorino, D., Montufar, E. B., (2012). Calcium phosphate cements as drug delivery materials Advanced Drug Delivery Reviews 64, 12, 1090-1110

Mattotti, Marta, Alvarez, Zaida, Ortega, Juan A., Planell, Josep A., Engel, Elisabeth, Alcántara, Soledad, (2012). Inducing functional radial glia-like progenitors from cortical astrocyte cultures using micropatterned PMMA Biomaterials 33, 6, 1759-1770

Gustavsson, J., Ginebra, M. P., Planell, J., Engel, E., (2012). Electrochemical microelectrodes for improved spatial and temporal characterization of aqueous environments around calcium phosphate cements Acta Biomaterialia 8, 1, 386-393

Tejeda-Montes, E., Smith, K. H., Poch, M., López-Bosque, M. J., Martín, L., Alonso, M., Engel, E., Mata, Alvaro., (2012). Engineering membrane scaffolds with both physical and biomolecular signaling Acta Biomaterialia 8, 3, 998-1009

Aguirre, A., Gonzalez, A., Navarro, M., Castano, O., Planell, J. A., Engel, E., (2012). Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis European Cells & Materials 24, 90-106

Levato, Riccardo, Mateos-Timoneda, Miguel A., Planell, Josep A., (2012). Preparation of biodegradable polylactide microparticles via a biocompatible procedure Macromolecular Bioscience 12, 4, 557-566

Navarro, M., Pu, F., Hunt, J. A., (2012). The significance of the host inflammatory response on the therapeutic efficacy of cell therapies utilising human adult stem cells Experimental Cell Research 318, 4, 361-370

Gustavsson, J., Ginebra, M. P., Planell, J., Engel, E., (2012). Osteoblast-like cellular response to dynamic changes in the ionic extracellular environment produced by calcium-deficient hydroxyapatite Journal of Materials Science-Materials in Medicine 23, 10, 2509-2520

Ambrosio, L., Guarino, V., Sanginario, V., Torricelli, P., Fini, M., Ginebra, M.P., Planell, J.A., Giardino, R., (2012). Injectable calcium-phosphate-based composites for skeletal bone treatments Biomedical Materials 7, 2, 1-10

Noailly, Jérôme, Ambrosio, Luigi, Elizabeth Tanner, K., Planell, Josep, Lacroix, Damien, (2012). In silico evaluation of a new composite disc substitute with a L3–L5 lumbar spine finite element model European Spine Journal 21, 5, 675-687

Pegueroles, M., Tonda-Turo, C., Planell, J. A., Gil, F. J., Aparicio, C., (2012). Adsorption of fibronectin, fibrinogen, and albumin on TiO2: Time-resolved kinetics, structural changes, and competition study Biointerphases 7, 48, 13

Serra, T., Navarro, M., Planell, J. A., (2012). Fabrication and characterization of biodegradable composite scaffolds for tissue engineering Innovative Developments in Virtual and Physical Prototyping Taylor & Francis VR@P, 67-72

Navarro, M., Planell, J. A., (2012). Composite scaffolds for bone tissue engneering John Wiley & Sons , 544-558

Castaño, O., Eltohamy, M., Kim, H. W., (2012). Electrospinning technology in tissue regeneration Springer 811, 127-140

Navarro, M., Planell, J. A., (2012). Is nanotechnology the key to unravel and engineer biological processes? Springer 811, 1-16

Navarro, M., Planell, J. A., (2012). Nanotechnology in Regenerative Medicine Springer 811, 811, 319

Equipment

  • Surface characterization equipment (contact angle, Z potential, nanoindenter)
  • Cell culture facilities
  • Molecular Biology equipment: protein and DNA electrophoresis
  • Thermocycler (PCR)
  • Rapid prototyping tool (part of the Production of biomaterials and nanoparticles platform of the CIBER-BBN)
    http://www.ciber-bbn.es/programas/plataformas/equipamiento/biomateriales?nodo=nodo2&locale=en
  • Peptide synthetiser
  • Combustion furnace
  • Electrospinning device
  • Spin-coater
  • Vibrational viscosimeter
  • ElectroForce® BioDynamic® test instrument

Collaborations

  • Dr. Ernest Mendoza
    Applied Nanomaterials Laboratory, Research Centre in Nanoengineering, Technical University of Catalonia (UPC, BarcelonaTech), Spain
  • Dr. Izabella Rajzer
    Institute of Textile Engineering and Polymer Materials, University of Bielsko-Biala, Poland
  • Dr. José María Mora
    Servei de cirurgia ortopédica i traumatológica, Consorci Hospital de Terrassa, Spain
  • Dr. Mercè Alsina
    Servicio de Dermatología, Hospital Clínic de Barcelona, Spain
  • Prof. Didier Letourneur
    Laboratoire de Bioingénierie Cardiovasculaire, INSERM, University Denis Diderot-Paris 7, Paris, France
  • Prof. Dirk Grijpma
    Department of Biomaterials Science and Technology, University of Twente, Twente, the Netherlands
  • Prof. Francesco Serino
    Department of Vascular Surgery, Istituto Dermatologico dell’Immacolata (IDI), Rome, Italy
  • Dr. Jerónimo Blanco
    Institut de Ciències Cardiovasculars de Catalunya and CSIC, Barcelona, Spain
  • Dr. Joelle Amedee
    INSERM, University of Bordeaux Segolen, Bordeaux, France
  • Dr. José Becerra Ratia
    Dept. Biología Celular, Genética y Fisiología, Universidad de Málaga, Spain
  • Dr. José Carlos Rodríguez-Cabello
    Dept. de Física de la Materia Condensada, Universidad de Valladolid, Spain
  • Dr. Julia Buján
    Dept. de Ciencias Morfológicas y Cirugía, Facultad de Medicina, Universidad de Alcalá de Henares, Spain
  • Prof. Kevin Healy
    Biomaterials & Tissue Engineering Laboratory, University of California at Berkeley, USA
  • Prof. Jaume Veciana
    NANOMOL, Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Spain
  • Dr. Diego Gutiérrez de la Iglesia (MD)
    Pediatric orthopaedic surgery, San Juan de Dios Hospital, Spain
  • Dr. Małgorzata Lewandowska
    Faculty of Materials Science & Engineering, WUT Warsaw University of Technology, Poland
  • Dr. Manuel Doblaré
    Group of Structural Mechanics and Materials Modelling, Institute of Engineering Research, (I3A), Universidad de Zaragoza, Spain
  • Dr. Margarita Calonge
    Institute of Ophthalmobiology (IOBA), Universidad de Valladolid, Spain
  • Dr. María Vallet Regí
    Facultad de Farmacia, Universidad Complutense de Madrid, Spain
  • Prof. Mateo Santin
    Brighton Studies in Tissue Mimicry and Aided Regeneration (BrightSTAR) Research Group, University of Brighton, UK
  • Prof. Wouter J.A. Dhert & Dr. Jos Malda
    Department of Orthopaedics, University Medical Center Utrecht, The Netherlands
  • Prof. Andrés J. García, F.B.S.E.
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA
  • Dr. Luigi Ambrosio
    Institute of Polymers, Composites & Biomaterials, National Research Council, Naples, Italy
  • Prof. Carlos Semino
    Grupo de Insuficiencia Cardíaca y Regeneración Cardíaca (ICREC), IQS School of Engineering, Universitat Ramon Llull

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