Molecular and cellular neurobiotechnology

José Antonio Del Río Fernández | Group Leader
Rosalina Gavín Marín | Senior Researcher
Vanessa Gil Fernández | Postdoctoral Researcher
Arnau Hervera Abad | Postdoctoral Researcher
Laia Lidón Gil | PhD Student
Ana López Mengual | PhD Student
Agata Mata Rodríguez | PhD Student
Andreu Matamoros Anglès | PhD Student
Laura Urrea Zazurca | PhD Student
Miriam Segura Feliu | Laboratory Technician
Francina Mesquida Veny | Masters Student


Our research interests are focused on three main aspects of developmental neurobiology and regeneration:

1) Reelin and neurodegeneration
Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation and plasticity. Most of these roles are mediated by the intracellular phosphorylation of Dab1, an intracellular adaptor molecule, in turn mediated by binding Reelin to its receptors. Altered expression and glycosylation patterns of Reelin in cerebrospinal and cortical extracts have been reported in Alzheimer’s disease. However, putative changes in Reelin are not described in natural prionopathies or experimental models of prion infection or toxicity. With this is mind, in the study we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection. However, changes in Reelin expression appeared only at late terminal stages of the disease, which prevents their use as an efficient diagnostic biomarker. In addition, increased Reelin in CJD and in in vitro models does not correlate with Dab1 phosphorylation, indicating failure in its intracellular signaling. Overall, these findings widen our understanding of the putative changes of Reelin in neurodegeneration.

Primary neuronal culture. Neurons (green) and astrocytes (red) derived from a E16.5 eGFP transgenic mouse embryo after 15 days in vitro

2) New in vitro models for neurodegeneration
The cellular prion protein, encoded by the gene PRNP, has been reported as receptor of b-amyloid. Their interaction is mandatory for neurotoxic effects of b-amyloid oligomers. In the study we aimed to explore whether the cellular prion protein participates in the spreading of a-synuclein. For this we developed cell to cell transport using microfluidic devices. Results demonstrate that PRNP expression is not mandatory for a-synuclein spreading. However, although the pathological spreading of a-synuclein can take place in the absence of PRNP, a-synuclein fibrils bind strongly on PRNP expressing cells, suggesting a role modulating the effect of a-synuclein fibrils.

3) Development of new lab on a chip devices for neurobiological research
We recently developed a new device able to reproduce axon lesioning in vitro in a single chip. Current experiments of our group in collaboration with groups of IBEC and CIBER-BBN aimed at developing new lab on chip devices to mimics and modulate particular neurobiological processes. For example: cortico-spinal chips to develop genetic studies; molecular gradient generation for migrating neurons and in silico 3D modeling for neurodegenerative diseases (Alzheimer chip).


A cellular model to help study the relationship between neurodegenerative diseases

From the cells of a patient with a rare neurodegenerative disease, Gerstmann-Sträussler-Scheinker syndrome (GSS), researchers at IBEC have managed to generate neurons that also present parallel neurodegenerative processes unrelated to the syndrome.

A new therapeutic target that could slow the progression of Parkinson’s disease

Researchers at IBEC have identified a potential way to slow down the neurodegenerative progression of Parkinson’s disease

Findings on seizure susceptibility open new avenues to understanding epilepsy in rapid progressive dementia

IBEC researchers have revealed the role played by the cellular prion protein (PrPC) – which is associated with a plethora of biological functions including cell proliferation, differentiation and signaling – in epilepsy.

A major step towards repairing the spinal cord

Researchers at the Institute for Bioengineering of Catalonia and their collaborators reveal that they’re a step closer to optimizing cells able to guide regeneration of the spine

IBEC groups in neuroscience map

IBEC’s Nanoprobes and nanoswitches and Molecular and Cellular Neurobiotechnology groups are two of the 120 groups featured on the Mapa de la Recerca en Neurociències a Catalunya. Created by the Societat Catalana de Biologia and hosted by IEC, the map aims to be a useful way of depicting the state-of-the-art of research in neuroscience in the region, and also a practical tool for researchers and science communicators.
Check it out here.

IBEC group to receive Marató funding for Parkinson’s research

IBEC’s Molecular and Cellular Neurobiotechnology group is to receive funding from 2013’s La Marató de TV3 for their project “Role of the cellular prion protein as “cross-talk” protein between a-syn/ LRRK2 and p-Tau in sporadic and familiar Parkinson´s disease.

Why Alzheimer’s patients have no memory loss when the disease starts

Researchers at IBEC and the UB have discovered a new factor that participates in the lack of symptoms in the early stages of Alzheimer’s disease – which is one handicap that makes the disease so hard to diagnose.

Molecular mechanisms that regulate the migration of Cajal-Retzius cells during brain development shown for the first time

Researchers from IBEC and the University de Barcelona (UB), in collaboration with the Institute of Marseille Luminy, University of the Mediterranean in France and the Cincinnati Children’s Hospital, USA, have identified for the first time a new molecular mechanism regulating the migration of Cajal-Retzius cells in the early stages of development of the cerebral cortex, the outermost layer of the brain.

Shedding new light on myelination and potential therapies for MS

Research done at IBEC that was published in the journal Cell. Mol. Life Sci. last week reveals a hopeful new lead in the quest to understand neurodegenerative diseases such as multiple sclerosis.

EU funding for research into Alzheimer’s and prioniopathies

A project involving IBEC through its affiliation with CIBERNED has been approved by the EU for funding.

Shedding light on misbehaving cells

Much like a kindergarten full of unruly toddlers, the cells that contribute to the body’s crucial processes can’t always be trusted to do what you want or expect them to do. Now IBEC researchers have made an important breakthrough that could contribute to the development of therapies for spinal and neural diseases: they’ve figured out exactly what it is that makes certain cells misbehave in particular circumstances.

‘Identifying an essential interaction for epilepsy’

The Molecular and Cellular Neurotechnology group’s recent paper on the development of epilepsy made the news today in Diario Medico, Spain’s leading newspaper for health professionals.

‘Beating the regeneration blockers’ on the web

The 12 November press release about the Molecular and Cellular Neurobiotechnology group’s research on inhibitory molecules in neuroregeneration, ‘Beating the regeneration blockers’, was picked up by various online scientific and health news sites including, the UK’s MS Trust and Cell DNA.

Beating the regeneration blockers

IBEC researchers shed light on inhibitory molecules in neuroregeneration

Advances in neuronal regeneration

Prof. José Antonio del Río, leader of the Molecular and Cellular Neurobiotechnology research line at IBEC, has participated in a study on neural regeneration published in the journal Chemistry and Biology of the Cell group.


National projects
DEVREG Nuevas funciones de PlexinD1/Sema3E, PrPC y las proteínas asociadas a la mielina durante el desarrollo de la corteza cerebral de roedores y en neurodegeneración (2013-2016) MINECO Investigación fundamental no orientada José Antonio Del Río
Red Nacional de Priones (2015-2017) MINECO, Acciones Dinamización “Redes Excelencia” José Antonio Del Río
ANGIODEVSNC Funciones de genes implicados en angiogénesis y remodelación vascular durante el desarrollo cortical y en neurodegeneración MINECO, Retos investigación: Proyectos I+D José Antonio Del Río
Role of the cellular prion protein as “cross-talk” protein between a-syn/ LRRK2 and p-Tau in sporadic and familiar Parkinson’s disease (2015-2018) Fundació La Marató de TV3 José Antonio Del Río
NEURODEV Nuevas funciones de PlexinD1/Sema3E, PrPC y las proteínas asociadas a la mielina durante el desarrollo de la corteza cerebral (2013-2016) MINECO, I+D-Investigación fundamental no orientada José Antonio Del Río
Mecanismos epigenéticos implicados en la etiología y progresión de las demencias neurodegenerativas rápidamente progresivas (2015-2016) MINECO José Antonio Del Río/Miguel Calero
Privately-funded projects
Monitoring neurocognitive deficits in Alzheimer’s and Parkinson’s diseases using saliva or blood-derived biomarkers and a multiplexed approach Obra Social La Caixa José Antonio Del Río


Frau-Méndez, Margalida A., Fernández-Vega, Iván, Ansoleaga, Belén, Blanco, Rosa, Carmona, Margarita, Antonio del Rio, Jose, Zerr, Inga, Llorens, Franc, Zarranz, Juan José, Ferrer, Isidro, (2017). Fatal familial insomnia: Mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus Brain Pathology 27, 1, 95-106 [Open Access]

Urrea, L., Segura-Feliu, M., Masuda-Suzukake, M., Hervera, A., Pedraz, L., Aznar, J. M. G., Vila, M., Samitier, J., Torrents, E., Ferrer, I., Gavín, R., Hagesawa, M., Del Río, J. A., (2017). Involvement of cellular prion protein in Molecular Neurobiology , 1-14

Gutiérrez-Franco, Ana, Eixarch, Herena, Costa, Carme, Gil, Vanessa, Castillo, Mireia, Calvo-Barreiro, Laura, Montalban, Xavier, Del Río, José A., Espejo, Carmen, (2017). Semaphorin 7A as a potential therapeutic target for multiple sclerosis Molecular Neurobiology , 1-12

Mata, A., Urrea, L., Vilches, S., Llorens, F., Thüne, K., Espinosa, J. C., Andréoletti, O., Sevillano, A. M., Torres, J. M., Requena, J. R., Zerr, I., Ferrer, I., Gavín, R., Del Río, J. A., (2017). Reelin Expression in Creutzfeldt-Jakob Disease and Experimental Models of Transmissible Spongiform Encephalopathies Molecular Neurobiology , 1-14

Garcia-Calero, Elena, Botella-Lopez, Arancha, Bahamonde, Olga, Perez-Balaguer, Ariadna, Martinez, Salvador, (2016). FoxP2 protein levels regulate cell morphology changes and migration patterns in the vertebrate developing telencephalon Brain Structure and Function 221, 6, 2905-2917 [Open Access]

Vilches, S., Vergara, C., Nicolás, O., Mata, A., Del Río, J. A., Gavín, R., (2016). Domain-specific activation of death-associated intracellular signalling cascades by the cellular prion protein in neuroblastoma cells Molecular Neurobiology 53, 7, 4438–4448

Ansoleaga, B., Garcia-Esparcia, Paula, Llorens, Franc, Hernández-Ortega, Karina, Carmona Tech, Margarita, Antonio del Rio, José, Zerr, Inga, Ferrer, Isidro, (2016). Altered mitochondria, protein synthesis machinery, and purine metabolism are molecular contributors to the pathogenesis of Creutzfeldt–Jakob disease Journal of Neuropathology & Experimental Neurology 75, 8, 755-769

Tomas-Roig, J., Piscitelli, F., Gil, V., del Río, J. A., Moore, T. P., Agbemenyah, H., Salinas-Riester, G., Pommerenke, C., Lorenzen, S., Beißbarth, T., Hoyer-Fender, S., Di Marzo, V., Havemann-Reinecke, U., (2016). Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice Behavioural Brain Research 303, 34-43

del Río, J. A., Gavín, R., (2016). Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory Prion 10, 1, 25-40

Requena, J. R., Kristensson, K., Korth, C., Zurzolo, C., Simmons, M., Aguilar-Calvo, P., Aguzzi, A., Andreoletti, O., Benestad, S. L., Böhm, R., Brown, K., Calgua, B., del Río, J. A., Espinosa, J. C., Girones, R., Godsave, S., Hoelzle, L. E., Knittler, M. R., Kuhn, F., Legname, G., Laeven, P., Mabbott, N., Mitrova, E., Müller-Schiffmann, A., Nuvolone, M., Peters, P. J., Raeber, A., Roth, K., Schmitz, M., Schroeder, B., Sonati, T., Stitz, L., Taraboulos, A., Torres, J. M., Yan, Z. X., Zerr, I., (2016). The Priority position paper: Protecting Europe's food chain from prions Prion 10, 3, 165-181 [Open Access]

Ferrer, I., Llorens, F., Frau-Mendez, L., Fernandez-Vega, I., Thune, K., del Río, J. A., Schmizt, M., Ansoleaga, B., Gotzmann, N., Cramm, M., Zerr, I., Zarranz, Juan José, (2016). EfiIdentification of new molecular alterations in Fatal Familial Insomnia Prion Taylor & Francis 10, Supplement, P-092

Reginensi, Diego, Carulla, Patricia, Nocentini, Sara, Seira, Oscar, Serra-Picamal, Xavier, Torres-Espín, Abel, Matamoros-Angles, Andreu, Gavín, Rosalina, Moreno-Flores, María Teresa, Wandosell, Francisco, Samitier, Josep, Trepat, Xavier, Navarro, Xavier, del Río, José Antonio, (2015). Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord Cellular and Molecular Life Sciences 72, 14, 2719-2737

Vergara, C., Ordóñez-Gutiérrez, L., Wandosell, F., Ferrer, I., del Río, J. A., Gavín, R., (2015). Role of PrPC expression in tau protein levels and phosphorylation in alzheimer's disease evolution Molecular Neurobiology 51, 3, 1206-1220

Carulla, Patricia, Llorens, Franc, Matamoros-Angles, Andreu, Aguilar-Calvo, Patricia, Espinosa, Juan Carlos, Gavín, Rosalina, Ferrer, Isidre, Legname, Giuseppe, Torres, Juan Maria, del Río, José A., (2015). Involvement of PrPC in kainate-induced excitotoxicity in several mouse strains Scientific Reports 5, 11971

Llorens, Franc, Zafar, Saima, Ansoleaga, Belén, Shafiq, Mohsin, Blanco, Rosi, Carmona, Marga, Grau-Rivera, Oriol, Nos, Carlos, Gelpí, Ellen, del Río, José Antonio, Zerr, Inga, Ferrer, Isidre, (2015). Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease Neuropathology and Applied Neurobiology 41, 5, 631-645

Perez-Balaguer, Ariadna, Ortiz-Martínez, Fernando, García-Martínez, Araceli, Pomares-Navarro, Critina, Lerma, Enrique, Peiró, Gloria, (2015). FOXA2 mRNA expression is associated with relapse in patients with Triple-Negative/Basal-like breast carcinoma Breast Cancer Research and Treatment 153, 2, 465-474

Tomas Roig, J., Piscitelli, F., Gil, V., Havemann Reinecke, U., (2015). Chronic psychosocial stress and endocannabinoid system interact to affect the transcription of SLC6A4, in the mouse corticostriatal circuits European Neuropsychopharmacology Elsevier 25, Supplement 2, P.1.a.001

Bribián, A., Nocentini, S., Llorens, F., Gil, V., Mire, E., Reginensi, D., Yoshida, Y., Mann, F., Del Río, J. A., (2014). Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex Nature Communications 5, 4265

Llorens, F., Ferrer, I., del Río, J. A., (2014). Gene expression resulting from PrPC ablation and PrPC overexpression in murine and cellular models Molecular Neurobiology 49, 1, 413-423

Seira, O., del Río, J. A., (2014). Glycogen synthase kinase 3 beta (GSK3 Molecular Neurobiology 49, 2, 931-944

Tong, Z., Seira, O., Casas, C., Reginensi, D., Homs-Corbera, A., Samitier, J., Del Río, J. A., (2014). Engineering a functional neuro-muscular junction model in a chip RSC Advances 4, 97, 54788-54797

Gil, V., Nocentini, S., del Río, J. A., (2014). Historical first descriptions of Cajal-Retzius cells: From pioneer studies to current knowledge Frontiers in Neuroanatomy 8, Article 32 (9)

La Torre, A., Del Mar Masdeu, M., Cotrufo, T., Moubarak, R. S., Del Río, J. A., Comella, J. X., Soriano, E., Ureña, J. M., (2013). A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching Cell Death and Disease 4, 4, e602

Berenguer, Jordi, Herrera, Antonio, Vuolo, Laura, Torroba, Blanca, Llorens, Franc, Sumoy, Lauro, Pons, Sebastian, (2013). MicroRNA 22 Regulates Cell Cycle Length in Cerebellar Granular Neuron Precursors Molecular and Cellular Biology 33, 14, 2706-2717

Ordoñez-Gutiérrez, L., Torres, J. M., Gavín, R., Antón, M., Arroba-Espinosa, A. I., Espinosa, J. C., Vergara, C., del Río, J. A., Wandosell, F., (2013). Cellular prion protein modulates Neurobiology of Aging 34, 12, 2793-2804

Llorens, F., Carulla, P., Villa, A., Torres, J. M., Fortes, P., Ferrer, I., Del Río, J. A., (2013). PrPC regulates epidermal growth factor receptor function and cell shape dynamics in Neuro2a cells Journal of Neurochemistry 127, 1, 124-138

Llorens, Franc, Banez-Coronel, Monica, Pantano, Lorena, del Rio, Jose, Ferrer, Isidre, Estivill, Xavier, Marti, Eulalia, (2013). A highly expressed miR-101 isomiR is a functional silencing small RNA BMC Genomics 14, 1, 104

Llorens, F., Hummel, M., Pantano, L., Pastor, X., Vivancos, A., Castillo, E., Mattlin, H., Ferrer, A., Ingham, M., Noguera, M., Kofler, R., Dohm, J. C., Pluvinet, R., Bayés, M., Himmelbauer, H., del Rio, J. A., Martí, E., Sumoy, L., (2013). Microarray and deep sequencing cross-platform analysis of the mirRNome and isomiR variation in response to epidermal growth factor BMC Genomics 14, 1, 1-15

Vilches, S., Vergara, C., Nicolás, O., Sanclimens, G., Merino, S., Varón, S., Acosta, G. A., Albericio, F., Royo, M., Del Río, J. A., Gavín, R., (2013). Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein PLoS ONE 8, 8, e70881

Riggio, C., Nocentini, S., Catalayud, M. P., Goya, G. F., Cuschieri, A., Raffa, V., del Río, J. A., (2013). Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue International Journal of Molecular Sciences 14, 6, 10852-10868

Llorens, F., Ansoleaga, B., Garcia-Esparcia, P., Zafar, S., Grau-Rivera, O., López-González, I., Blanco, R., Carmona, M., Yagüe, J., Nos, C., Del Río, J. A., Gelpí, E., Zerr, I., Ferrer, I., (2013). PrP mRNa and protein expression in brain and PrPc in CSF in Creutzfeldt-Jakob disease MM1 and VV2 Prion 7, 5, 383-393

Gil, V., Del Río, J. A., (2012). Analysis of axonal growth and cell migration in 3D hydrogel cultures of embryonic mouse CNS tissue Nature Protocols 7, 2, 268-280

Nocentini, S., Reginensi, D., Garcia, S., Carulla, P., Moreno-Flores, Wandosell, F., Trepat, X., Bribian, A., Del Rí, (2012). Myelin-associated proteins block the migration of olfactory ensheathing cells: an in vitro study using single-cell tracking and traction force microscopy Cellular and Molecular Life Sciences 69, 10, 1689-1703

Armendáriz, Beatriz G., Bribian, Ana, Pérez-Martínez, Esther, Martínez, Albert, de Castro, Fernando, Soriano, Eduardo, Burgaya, Ferran, (2012). Expression of Semaphorin 4F in neurons and brain oligodendrocytes and the regulation of oligodendrocyte precursor migration in the optic nerve Molecular and Cellular Neuroscience 49, 1, 54-67

Bribián, Ana, Fontana, Xavier, Llorens, Franc, Gavín, Rosalina, Reina, Manuel, García-Verdugo, José Manuel, Torres, Juan María, de Castro, Fernando, Del Río, J.A., (2012). Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS PLoS ONE 7, 4, e33872

Llorens, F., Del Rio, J. A., (2012). Unraveling the neuroprotective mechanisms of PrPC in excitotoxicity Prion 6, 3, 245-251

Llorens, Franc, Gil, Vanessa, Antonio del Rio, Jose, (2011). Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration FASEB Journal 25, 2, 463-475

Carulla, Patricia, Bribian, Ana, Rangel, Alejandra, Gavin, Rosalina, Ferrer, Isidro, Caelles, Carme, Antonio del Rio, Jose, Llorens, Franc, (2011). Neuroprotective role of PrP(C) against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 binding Molecular Biology of the Cell 22, 17, 3041-3054

Llorens, Franc, Hummel, Manuela, Pastor, Xavier, Ferrer, Anna, Pluvinet, Raquel, Vivancos, Ana, Castillo, Ester, Iraola, Susana, Mosquera, Ana M., Gonzalez, Eva, Lozano, Juanjo, Ingham, Matthew, Dohm, Juliane C., Noguera, Marc, Kofler, Robert, Antonio del Rio, Jose, Bayes, Monica, Himmelbauer, Heinz, Sumoy, Lauro, (2011). Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis BMC Genomics 12, 326

del Rio, Jose Antonio, Soriano, Eduardo, (2010). Regenerating cortical connections in a dish: the entorhino-hippocampal organotypic slice co-culture as tool for pharmacological screening of molecules promoting axon regeneration Nature Protocols 5, 2, 217-226

Martí, E., Pantano, L., Bañez-Coronel, M., Llorens, F., Miñones-Moyano, E., Porta, S., Sumoy, L., Ferrer, I., Estivill, X., (2010). A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing Nucleic Acids Research 38, 20, 7219-7235

Gil, Vanessa, Bichler, Zoe, Lee, Jae K., Seira, Oscar, Llorens, Franc, Bribian, Ana, Morales, Ricardo, Claverol-Tinture, Enric, Soriano, Eduardo, Sumoy, Lauro, Zheng, Binhai, del Rio, Jose A., (2010). Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon Cerebral Cortex 20, 8, 1769-1779

Gavín, R., Ferrer, I., del Río, J. A., (2010). Involvement of Dab1 in APP processing and [beta]-amyloid deposition in sporadic Creutzfeldt-Jakob patients Neurobiology of Disease 37, 2, 324-329

Madronal, Noelia, Lopez-Aracil, Cristina, Rangel, Alejandra, del Rio, Jose A., Delgado-Garcia, Jose M., Gruart, Agnes, (2010). Effects of Enriched Physical and Social Environments on Motor Performance, Associative Learning, and Hippocampal Neurogenesis in Mice PLoS ONE 5, 6, e11130

Seira, O., Gavin, R., Gil, V., Llorens, F., Rangel, A., Soriano, E., del Rio, J. A., (2010). Neurites regrowth of cortical neurons by GSK3 beta inhibition independently of Nogo receptor 1 Journal of Neurochemistry 113, 6, 1644-1658

Messeguer, J., Masip, I., Montolio, M., del Rio, J. A., Soriano, E., Messeguer, A., (2010). Peptoids bearing tertiary amino residues in the n-alkyl side chains: synthesis of a potent inhibitor of Semaphorin 3A Tetrahedron 66, 13, 2444-2454

Nicolas, O., Gavin, R., Del Rio, J. A., (2009). New insights into cellular prion protein (PrPc) functions: The "ying and yang" of a relevant protein Brain Research Reviews 61, 2, 170-184

Rangel, A., Madroñal, N., Gruart i Massó, A., Gavin,, Llorens, Sumoy, Torres, Delgado-Gar, Del Rio, J. A., (2009). Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice PLoS ONE 4, 10, e7592 (1-14)


  • Neural stem cell culture
  • Microscopy facility (Olympus BX61 and Olympus IX71 with LCi culture and OKOlab systems)
  • Electroporation system (BTX 600)
  • Pressure microinjection system
  • Protein expression and purification systems
  • Technology of neuronal culture facilities (2D and 3D)
  • Lentiviral production and characterization
  • Gradient thermocycler (PCR)
  • Protein and DNA electrophoresis
  • In situ hybridization oven


  • Dr. Fernando de Castro
    Hospital Nacional de Parapléjicos, Toledo, Spain
  • Dr. Adolfo Lopéz de Munain
    Hospital de Donostia, San Sebastian, Spain
  • Dr. Jokin Castilla
    CiC Biogune, Bilbao, Spain
  • Prof. Jose Manuel García Verdugo
    Facultad de Ciencias, Universidad de Valencia, Spain
  • Prof. Jose Manuel García Aznar
    Nanotechnology Institute, Zaragoza, Spain
  • Prof. Fernando Albericio
    Institute for Research in Biomedicine (IRB), Barcelona
  • Dra. Miriam Royo
    Institute for Research in Biomedicine (IRB), Barcelona
  • Dr. Elisabeth Engel, Prof. Josep Samitier, Prof. Xavier Trepat
  • Prof. Ángel Raya
    Center of Regenerative Medicine in Barcelona (CMRB), Barcelona
  • Prof. Jesús Ávila and Prof. Francisco Wandosell
    Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid, Spain
  • Prof. Isidro Ferrer
    Institut d’Investigació Biomèdica de Bellvitge, University of Barcelona, Spain
  • Prof. Fanny Mann
    Developmental Institute of Marseille Luminy, Université de la Méditerranée, Marseille, France
  • Prof. Yutaka Yoshida
    Division of Developmental Biology, Cincinnati Children’s Research Foundation, Cincinnati, Ohio, USA
  • Prof. Masato Hagesawa
    Faculty of Medicine, Tokyo

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