Identifying an essential interaction for epilepsy
Scientists at the Institute for Bioengineering of Catalonia (IBEC) describe a major step towards the understanding of epilepsy in a paper published in Molecular Biology of the Cell.
In the study, the researchers shed new light on the importance of a neuronal protein known as PrPc, which performs a number of physiological functions in many neural processes. When mutated or misfolded, the pathogenic form of the protein, PrPsc, induces progressive conditions that affect the brain and nervous system, such as Creutzfeldt-Jakob disease and BSE, while in epilepsy it appears that the healthy protein plays a preventative role.