Large-scale curvature sensing by directional actin flow drives cellular migration mode switching

Cell migration is an essential biological process that drives tissue and organ formation during embryo development, and also helps protect the body through immune response and wound healing mechanisms. The shape changes necessary for cell migration depends on dynamic organization and force generation from the cell’s internal actomyosin cytoskeleton, which is made up of structural actin filaments and contractile myosin motor proteins.

Reorganization of these components enables two mechanisms of cell migration.